The Clinical Value of Glycated Haemoglobin and Glycated Plasma Proteins

Lester, Eva P.

doi:10.1177/000456328902600301

Cited by 46 publications

(17 citation statements)

References 55 publications

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“…9 However, the inherent variability of blood glucose concentrations often makes interpretation of a single blood glucose difficult and HbA 1c may be a more useful index to reflect chronic hyperglycaemia. 13 In the present analysis, we found significant associations between HbA 1c and CVD risk factors including blood pressure, central adiposity, plasma glucose, 2-h plasma insulin, lipid parameters, and urate concentrations in subjects with normal glucose tolerance. Some of the associations were explained by differences in age and sex.…”

Section: Discussionsupporting

confidence: 57%

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Glycated haemoglobin and cardiovascular risk factors in Chinese subjects with normal glucose tolerance

Woo

et al. 1998

Diabet. Med.

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Increased plasma glucose concentration is a predictive factor for mortality in both diabetic and non-diabetic subjects. Although glycated haemoglobin (HbA1c) is a useful index of mean blood glucose concentrations over the preceding 1 to 3 months, there are few data regarding its relationship to cardiovascular risk. We have examined the relationship between HbA1c and cardiovascular risk factors in 1280 subjects with normal glucose tolerance. Based on HbA1c tertiles (tertile 1: n = 427, 262 men and 165 women, HbA1c level: 2.9-4.7% in men and 3.2-4.2% in women; tertile 2: n = 426, 261 men and 165 women, HbA1c level: 4.7-5.1% in men and 4.2-4.6% in women; tertile 3: n = 427, 262 men and 165 women, HbA1c level: 5.1-6.7% in men and 4.6-6.9% in women), increasing HbA1c was associated with increasing age, blood pressure, waist-hip ratio, fasting and 2-h plasma glucose, 2-h insulin, cholesterol, low-density lipoprotein cholesterol, apolipoprotein B and urate concentrations. When age and sex were included as covariates, increasing HbA1c remained associated with increasing fasting and 2-h plasma glucose, 2-h insulin, total cholesterol, and low-density lipoprotein cholesterol concentrations. These findings emphasize the importance of hyperglycaemia, as reflected by HbA1c, as a continuum in the evaluation of cardiovascular risk. Furthermore, these findings support the hypothesis that cardiovascular disease risk commences with rising glucose concentrations before 'conventionally-defined' glucose intolerance occurs.

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Section: Discussionsupporting

confidence: 57%

“…12 Although HbA 1c is a useful index reflecting mean blood glucose concentrations over the preceding 1 to 3 months, 13 there is a paucity of data regarding its relationship to cardiovascular risk. We examine these associations in a survey of glucose intolerance and lipid abnormality in a Hong Kong Chinese working population.…”

mentioning

confidence: 99%

Glycated haemoglobin and cardiovascular risk factors in Chinese subjects with normal glucose tolerance

Woo

et al. 1998

Diabet. Med.

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“…The evidence available in this study may however not be able to prove that the same will be applicable to anemic patients, a very common problem in the tropics. The main use of glycated haemoglobin is to assess long -term glycemic control in the management of diabetic patients, to provide valuable informati<:m about the average blood glucose levels over the previous 1-2 months and to monitor compliance of patients to treatment regimens (Goldstein et al, 1982(Goldstein et al, & 1986Meidema and Casparie, 1984;Lester, 1989) In this study, while all the control subjects have FPG and HbA) levels within normal range (75-115mg/dl and 5 8%, respectively). About 15 (38%) of the diabetic patients have FPG within normal range and 28 (70%) have FPG below 140mg/dl, borderline for diabetes.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Fasting Plasma Glucose and Glycated Haemoglobin In Adult Diabetic Nigerians

Akinloye¹,

Adaramoye²,

Akinlade³

et al. 2010

African Journal of Biomedical Research

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The relationship between packed cell volume (PCV), fasting plasma glucose (FPG) and glycated haemoglobin (HbA I ) was investigated in 40 diabetic patients (22 males and 18 females) and 20 apparently healthy controls (12 males and 18 females). Among the control subjects the FPG and HbA1 were significantly higher in the female than male subjects (P < 0.001). This gender differences was not found in diabetic patients (P < 0.05). While all the control subjects have FPG and HbA1 level within normal range (75-115mg/dl and 5 -8 %, respectively), 15 (38%) of the diabetic patients had FPG level within normal and only 5 (13%) had HbA1 level within the normal range. The FPG and HbA1 values were however, significantly higher in diabetic patients (139.34 ± 7.06 and 12.09 ± 2.80) than control subjects (76.40 ± 1.24 and 6.24 ± 0.51), respectively (P < 0.001). The PCV in controls correlated significantly with FPG and HbA1 (P < 0.001) while the FPG correlated significantly with HbA1 (P < 0.001). There was however only a significant correlation between FPG and HbA1 in the diabetic subjects. Bland Ahman graph shows a good agreement between FPG and HbA1, in both test and control subjects. These results show that PCV and gender factors have significant influence on FPG and HbA1 level in control subjects and were insignificant in diabetic patients. FPG and / or HbA1 are important and agreeable indices for assessment of glucose metabolism. Furthermore, there was an evidence of poor glycemic control in diabetic patients investigated in this study, probably due to poor compliance culture of the patients or inability to procure recommended drugs.

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“…Figure 2 illustrates the well established methodological and statistical difficulties inherent in making accurate and meaningful comparisons of data on haemoglobin A1 28 29. In each study the mean level of haemoglobin A1 was well above its local normal range, however this was calculated, and a long way from “acceptable” according to published targets.…”

Section: Resultsmentioning

confidence: 99%

Glycated haemoglobin and metabolic control of diabetes mellitus: external versus locally established clinical targets for primary care

Butler

Peters

Stott

1995

BMJ

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The Clinical Value of Glycated Haemoglobin and Glycated Plasma Proteins

Cited by 46 publications

References 55 publications

Glycated haemoglobin and cardiovascular risk factors in Chinese subjects with normal glucose tolerance

Glycated haemoglobin and cardiovascular risk factors in Chinese subjects with normal glucose tolerance

Relationship between Fasting Plasma Glucose and Glycated Haemoglobin In Adult Diabetic Nigerians

Glycated haemoglobin and metabolic control of diabetes mellitus: external versus locally established clinical targets for primary care

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