The clinical utility of the local inflammatory response in colorectal cancer

Richards, Colin H.; Roxburgh, Campbell S.D.; Powell, Arfon; Foulis, Alan K.; Horgan, Paul G.; McMillan, Donald C.

doi:10.1016/j.ejca.2013.09.008

Cited by 78 publications

(121 citation statements)

References 32 publications

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“…The tumour-associated stroma, the generalised local inflammatory cell infiltrate and tumour budding have previously been characterised in this cohort using full haematoxylin & eosin (H&E)-stained sections of the deepest point of invasion according to previously published methodology (23)(24)(25)(26). The tumour-associated stroma was assessed using tumour stroma percentage (TSP) and graded as either low (≤50%) or high (>50%) (25).…”

Section: Assessment Of Tumour Microenvironmentmentioning

confidence: 99%

“…As the prognostic value of the Klintrup-Mäkinen grade has previously been shown to be similar to assessment of individual T-lymphocyte subsets (24), only Klintrup-Mäkinen grade was entered into the multivariable model. On multivariate survival analysis (Table 5) Although failing to reach statistical significance, the density of tumour-associated stroma, as measured by TSP, appeared to be associated with pSTAT3 expression.…”

Section: P=0039)mentioning

confidence: 99%

“…The tumour-associated stroma was assessed using tumour stroma percentage (TSP) and graded as either low (≤50%) or high (>50%) (25). The local inflammatory cell infiltrate was assessed using the Klintrup-Mäkinen (KM) grade and graded as either low-grade (no increase or mild/patchy increase in inflammatory cells at invasive margin) or high-grade (prominent band-like inflammatory reaction or florid cup-like inflammatory reaction at invasive margin with destruction of cancer cell islands) (27).…”

Section: Assessment Of Tumour Microenvironmentmentioning

confidence: 99%

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Signal Transduction and Activator of Transcription-3 (STAT3) in Patients with Colorectal Cancer: Associations with the Phenotypic Features of the Tumor and Host

Park

Wyk

McMillan

et al. 2017

Clinical Cancer Research

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(2017) Signal transduction and activator of transcription-3 (STAT3) in patients with colorectal cancer: associations with the phenotypic features of the tumour and host. Clinical Cancer Research, 23(7), pp. 1698 -1709 . (doi:10.1158 /1078 -0432.CCR-16-1416 This is the author's final accepted version.There may be differences between this version and the published version. You are advised to consult the publisher's version if you wish to cite from it.http://eprints.gla.ac.uk/129347/ Experimental DesignImmunohistochemical assessment of STAT3/pSTAT3 expression was performed using a tissue microarray and tumour cell expression divided into tertiles using the weighted histoscore. The relationship between STAT3/pSTAT3 expression and local inflammatory The combination of nuclear STAT3/pSTAT3 stratified five-year survival from 81% to 62% (P=0.012), however was not associated with survival independent of venous invasion, tumour perforation or tumour budding. ConclusionIn patients undergoing CRC resection, STAT3 expression was associated with adverse host inflammatory responses and reduced survival. Up-regulation of tumour STAT3 may be an important mechanism whereby the tumour deregulates local and systemic inflammatory responses.5

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Section: Assessment Of Tumour Microenvironmentmentioning

confidence: 99%

Section: P=0039)mentioning

confidence: 99%

Section: Assessment Of Tumour Microenvironmentmentioning

confidence: 99%

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Signal Transduction and Activator of Transcription-3 (STAT3) in Patients with Colorectal Cancer: Associations with the Phenotypic Features of the Tumor and Host

Park

Wyk

McMillan

et al. 2017

Clinical Cancer Research

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“…All methods seem to exhibit similar survival relationships in both node-positive and node-negative CRC, with a favorable prognostic impact of lymphocytic infiltrates (14).…”

Section: Methods For Assessing Immune Response In Colorectal Cancermentioning

confidence: 99%

“…Density is graded as absent, weak, moderate or strong in three separate compartments: (I) invasive margin (IM); (II) tumor stroma (ST) and (III) cancer cell nests (CCN) (14).…”

Section: Methods For Assessing Immune Response In Colorectal Cancermentioning

confidence: 99%

The significance of tumor-associated immune response in molecular taxonomy, prognosis and therapy of colorectal cancer patients

Nearchou

Pentheroudakis

2016

Ann. Transl. Med.

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The importance of host immune response in colorectal cancer (CRC) has been constantly revealed through the last 10 years. A number of relevant immune markers have been introduced as prognostic and are now been used alone or in combination with each other in clinical practice. Efforts establishing a worldwide consensus on the implications of immune-profiles in conjunction to other factors are designed in the right direction in order to more effectively categorize patients with CRC in groups that might benefit from currently used or future applied therapies. On the other hand, a number of clinical trials have evolved the application of immunotherapies in patients with CRC both in the adjuvant and palliative setting.

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Preoperative, biopsy‐based assessment of the tumour microenvironment in patients with primary operable colorectal cancer

Park

Wyk

Edwards

et al. 2019

The Journal of Pathology CR

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The tumour microenvironment (TME) is recognised as an important prognostic characteristic and therapeutic target in patients with colorectal cancer (CRC). However, assessment generally utilises surgically resected specimens, precluding neoadjuvant targeting. The present study investigated the feasibility of intra‐epithelial CD3+ T‐lymphocyte density and tumour stroma percentage (TSP) assessment using preoperative colonoscopic biopsies from 115 patients who had undergone resection of stages I–III CRC, examining the relationship between biopsy and surgically resected specimen‐based assessment, and the relationship with cancer‐specific survival (CSS). High biopsy CD3+ density was associated with high CD3+ density in the invasive margin, cancer stroma and intra‐epithelial compartments of surgically resected specimens (area under the curve > 0.62, p < 0.05 for all) and with high Immunoscore. High biopsy TSP predicted high TSP in resected specimens (p = 0.001). Intra‐class correlation coefficient for both measures was >0.7 (p < 0.001), indicating excellent concordance between individuals. Biopsy CD3+ density (hazard ratio [HR] 0.23, p = 0.002) and TSP (HR 2.23, p = 0.029) were independently associated with CSS; this was comparable to the prognostic value of full section assessment (HR 0.21, p = 0.004, and HR 2.25, p = 0.033 respectively). These results suggest that assessment of the TME is comparable in biopsy and surgically resected specimens from patients with CRC, and biopsy‐based assessment could allow for stratification prior to surgery or commencement of therapy targeting the TME.

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The clinical utility of the local inflammatory response in colorectal cancer

Cited by 78 publications

References 32 publications

Signal Transduction and Activator of Transcription-3 (STAT3) in Patients with Colorectal Cancer: Associations with the Phenotypic Features of the Tumor and Host

Signal Transduction and Activator of Transcription-3 (STAT3) in Patients with Colorectal Cancer: Associations with the Phenotypic Features of the Tumor and Host

The significance of tumor-associated immune response in molecular taxonomy, prognosis and therapy of colorectal cancer patients

Preoperative, biopsy‐based assessment of the tumour microenvironment in patients with primary operable colorectal cancer

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