The clinical utility of the auditory P300 latency subcomponent event-related potential in preclinical diagnosis of patients with mild cognitive impairment and Alzheimer’s disease

Howe, Aaron; Bani‐Fatemi, Ali; Luca, Vincenzo De

doi:10.1016/j.bandc.2014.01.015

Cited by 77 publications

(45 citation statements)

References 98 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A recent meta-analysis (20 studies, 646 subjects, mean MMSE per study ranging from 16.2 to 24.0; median: 20.2) performed by Hedges et al (2016) confirmed reduced P3 amplitude in patients with mild AD. This finding was corroborated in another meta-analysis that found increased P3 latency in patients with mild AD (Howe et al, 2014). Interestingly, this study also included a subanalysis of 8 studies focusing on patients with MCI.…”

Section: Electrophysiological Responses To Novelty In Adsupporting

confidence: 75%

Novelty processing and memory impairment in Alzheimer's disease: A review

Bastin

Delhaye

Moulin

et al. 2019

Neuroscience & Biobehavioral Reviews

View full text Add to dashboard Cite

The detection and processing of novelty plays a critical role in memory function. Despite this, relatively little is known about how novelty influences memory in Alzheimer's disease (AD). This review sought to address whether AD patients are still sensitive to novelty; whether novelty triggers memory processes as is observed in healthy subjects; and whether it is possible to promote novelty to enhance memory at the different stages of AD. The studies reviewed showed that novelty processing is mostly impaired in AD patients, whereas it can be preserved under some conditions in MCI, particularly when cognitive demands are otherwise low. We further identify outstanding questions that should be addressed in the near future in order to more robustly establish the fate of novelty processing and detection in the course of AD. Doing so would allow to improve current models of memory impairment in AD, leading to a more comprehensive view of the sources of memory decline and could lead to neuropsychological and/or pharmaceutical rehabilitation programs.

show abstract

Section: Electrophysiological Responses To Novelty In Adsupporting

confidence: 75%

Novelty processing and memory impairment in Alzheimer's disease: A review

Bastin

Delhaye

Moulin

et al. 2019

Neuroscience & Biobehavioral Reviews

View full text Add to dashboard Cite

show abstract

“…Furthermore, evoked potentials were assessed using a 15 min Novelty-Oddball-Paradigm (P300), and a 15 min Intensity Dependence of Auditory Evoked Potentials paradigm [ 27 , 28 ]. Alterations in P300-amplitude and latency have been linked to neurodegenerative processes and IAEP-magnitude has been linked to serotonin levels in the brain [ 28 , 29 ]. All EEG recordings were performed by trained staff in an electrically shielded and sound attenuated EEG booth using a 31-channel EEG (QuickAmp, Brain Products GmbH).…”

Section: Methodsmentioning

confidence: 99%

The LIFE-Adult-Study: objectives and design of a population-based cohort study with 10,000 deeply phenotyped adults in Germany

et al. 2015

View full text Add to dashboard Cite

BackgroundThe LIFE-Adult-Study is a population-based cohort study, which has recently completed the baseline examination of 10,000 randomly selected participants from Leipzig, a major city with 550,000 inhabitants in the east of Germany. It is the first study of this kind and size in an urban population in the eastern part of Germany. The study is conducted by the Leipzig Research Centre for Civilization Diseases (LIFE). Our objective is to investigate prevalences, early onset markers, genetic predispositions, and the role of lifestyle factors of major civilization diseases, with primary focus on metabolic and vascular diseases, heart function, cognitive impairment, brain function, depression, sleep disorders and vigilance dysregulation, retinal and optic nerve degeneration, and allergies.Methods/designThe study covers a main age range from 40-79 years with particular deep phenotyping in elderly participants above the age of 60. The baseline examination was conducted from August 2011 to November 2014. All participants underwent an extensive core assessment programme (5-6 h) including structured interviews, questionnaires, physical examinations, and biospecimen collection. Participants over 60 underwent two additional assessment programmes (3-4 h each) on two separate visits including deeper cognitive testing, brain magnetic resonance imaging, diagnostic interviews for depression, and electroencephalography.DiscussionThe participation rate was 33 %. The assessment programme was accepted well and completely passed by almost all participants. Biomarker analyses have already been performed in all participants. Genotype, transcriptome and metabolome analyses have been conducted in subgroups. The first follow-up examination will commence in 2016.

show abstract

“…In our study, the AD group exhibited significantly reduced P3a amplitudes in response to deviant stimuli compared to NC. Most previous studies analyzing P3a in adults with AD have used an auditory modality (57)(58)(59)(60)(61). In these studies on auditory P3a of adults with AD, some reported an extended latency (60) or reduced amplitude (59), while others reported no difference at all (61).…”

Section: Discussionmentioning

confidence: 99%

Pre-attentive processing of Alzheimer's disease: an event-related potential study

Lee

Kim

et al. 2019

Preprint

View full text Add to dashboard Cite

Background: While identifying Alzheimer’s Disease (AD) in its early stages is crucial, traditional neuropsychological tests tend to lack sensitivity and specificity for its diagnosis. Based on the early visual attention deficits of adults with AD, which are apparent before cognitive deficits emerge, this study aimed to investigate visual attentional characteristics of adults with AD, from pre-attentive to attentive processing, using a visual oddball task and event-related potentials (ERPs).Methods: Cognitively normal elderly controls (NC, n=27) and patients with probable AD (AD, n=10) were recruited. Participants performed a three-stimulus visual oddball task and were asked to press a designated button in response to the target stimuli. The amplitudes of 4 ERPs were analyzed. Visual mismatch-negativity (vMMN) was analyzed around the parieto-occipital and temporo-occipital regions. P3a was analyzed around the fronto-central regions, whereas P3b was analyzed around the centro-parietal regions.Results: Late vMMN amplitudes of the AD group were significantly smaller than those of the NC group, while early vMMN amplitudes were comparable. Compared to the NC group, P3a amplitudes of the AD group were significantly smaller for the infrequent deviant stimuli but the amplitudes for the standard stimuli were comparable. Lastly, the AD group had significantly smaller P3b amplitudes than the NC group.Conclusion: Our findings imply that AD patients exhibit pre-attentive visual processing deficits, known to affect later higher-order brain functions. In a clinical setting, the visual oddball paradigm could be used to provide helpful diagnostic information since pre-attentive ERPs can be induced by passive exposure to infrequent stimuli.

show abstract

The clinical utility of the auditory P300 latency subcomponent event-related potential in preclinical diagnosis of patients with mild cognitive impairment and Alzheimer’s disease

Cited by 77 publications

References 98 publications

Novelty processing and memory impairment in Alzheimer's disease: A review

Novelty processing and memory impairment in Alzheimer's disease: A review

The LIFE-Adult-Study: objectives and design of a population-based cohort study with 10,000 deeply phenotyped adults in Germany

Pre-attentive processing of Alzheimer's disease: an event-related potential study

Contact Info

Product

Resources

About