The Clinical Utility of Kidney Injury Molecule 1 in the Prediction, Diagnosis and Prognosis of Acute Kidney Injury: A Systematic Review

Huang, Yuancheng; Don-Wauchope, Andrew

doi:10.2174/187152811796117735

Cited by 81 publications

(70 citation statements)

References 31 publications

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“…[22,23]. Bupropion does not decrease significantly TNF-α levels (p=0.06) despite identifying a tendency of lowering, but it was necessary to conserve the renal function of the right kidney (Table 2).…”

Section: Discussionmentioning

confidence: 98%

Bupropion Cannot Reduce Acute Kidney Injury Due to Ischemia-Reperfusion

FJ¹,

AJ²,

JM³

et al. 2017

Clin Exp Pharmacol

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Bupropion can limit the increase of TNF-alpha, reducing the inflammatory response and injury due to IschemiaReperfusion (I/R) on tissues such as the bowel. Our objective was to evaluate bupropion as a preconditioning agent for ischemic acute kidney injury.Experiments were performed on female Wistar rats. Bupropion groups received 25 mg/kg 60 min before the maneuver. As a first step, 30 rats with a right nephrectomy were divided into 6 groups (n=5): sham 24, sham 48, bupropion 24, bupropion 48, ischemia-reperfusion 24 and ischemia-reperfusion 48. After 60 min of ischemia (except sham groups) 24 or 48 h of reperfusion was allowed. During a second step, 30 rats, with both kidneys conserved, were divided into 6 groups (n=5): sham 3, sham 72, bupropion 3, bupropion 72, ischemia-reperfusion 3, and ischemia-reperfusion 72 (IR72). Ischemia in these groups (except sham groups) was performed for 60 min only on the left kidney, and 3 or 72 h of reperfusion were allowed. Serum and histologic evaluations were done.After 48 h of reperfusion, all mono-renal rats that received bupropion died. Bupropion cannot avoid histological damage nor does it impact creatinine clearance, BUN, TNF-α or KIM-1 serum levels secondary to I/R. In conclusion: The pharmacologic preconditioning with Bupropion cannot improve the AKI evolution in rats with renal ischemiareperfusion injury.

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Section: Discussionmentioning

confidence: 98%

Bupropion Cannot Reduce Acute Kidney Injury Due to Ischemia-Reperfusion

FJ¹,

AJ²,

JM³

et al. 2017

Clin Exp Pharmacol

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“…Huang et al (16) found that the levels of the uKIM-1 are the highest in patients with acute ischemic tubular necrosis. Detected values of uKIM-1 among patients vary widely, and are influenced by the time.…”

Section: Discussionmentioning

confidence: 99%

“…Two large studies have shown that KIM-1 is an effective new urinary biomarker for the diagnosis of AKI in the first 24 h after kidney injury, especially for the diagnosis of ischemic AKI (15,16). Askenazi et al (6) examined the different urinary biomarkers as predictors of AKI and mortality in very-low-birthweight infants.…”

Section: Discussionmentioning

confidence: 99%

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Urinary kidney injury molecule-1 rapid test predicts acute kidney injury in extremely low-birth-weight neonates

et al. 2015

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Background:The new urinary and serum biomarkers are discovered and are being investigated. With them we can diagnose acute kidney injury (AKI) faster and more precisely and they also have a significant role in the outcome prediction. Methods: The study included 22 extremely low-birthweight neonates who were hospitalized in the neonatal intensive care units. They were divided into two groups based on serum creatinine (SCr) level-with and without AKI. Detection and quantification of urinary kidney injury molecule-1 (uKIM-1) was done on the third day of life, using commercially available KIM-1 rapid test. Subsequently, measurements were repeated only in subjects who were diagnosed with AKI, at different values of SCr. results: Logistic regression analysis showed that AKI is an independent risk factor for mortality. In a group of neonates with AKI, 50% of neonates administered the KIM-1 rapid test showed positive findings. KIM-1 rapid test was positive in patients with a wide range of SCr levels (range of 78.73-385 µmol/l), but all subjects had oliguria and died in the next 24 h. conclusion: KIM-1 is a significant predictor of death. On the other hand, our study failed to prove that KIM-1 rapid test has any significance for early prediction of AKI.

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“…20 In two recently published systematic reviews, it has been reported that KIM-1 was an effective and reliable urinary biomarker for diagnosing AKI within 24 h of renal injury. 21,22 Clinical studies have demonstrated the excessive tubular production of KIM-1 in FSGS, IgA nephropathy, and MPGN. Moreover, a linear and proportional correlation was revealed between increased KIM-1 levels, proteinuria, development of tubular damage, and interstitial fibrosis secondary to proteinuria.…”

Section: Discussionmentioning

confidence: 99%

Potential biomarkers for the early detection of acute kidney injury after percutaneous nephrolithotripsy

et al. 2015

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This study aims to investigate the role of urinary biomarkers in the determination of the potential risks of renal parenchymal tubular damage in adult patients who underwent percutaneous nephrolithotomy (PNL) with the indication of renal stone. A randomized and prospective controlled study was performed between June and December 2013. We enrolled 29 consecutive patients with renal calculi42 cm and who underwent PNL, as well as 47 healthy control subjects. Urine samples, including 2 h before surgery, 2 and 24 h after surgery were collected from the patient group. Freshly voided urine samples were collected from the control group. Kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-glucosaminidase (NAG), and liver-type fatty acid binding protein (LFABP) levels were measured from these urine samples. The mean KIM-1/Cr value that measured 24 h after the operation was statistically significant, higher than its preoperative (preop) level (p ¼ 0.045). A significant difference was detected between the mean preop and postoperative (postop) 24 h NAG/Cr values (p50.001). Also, postop 24 h NGAL/Cr levels were statistically significant, higher than its preop levels (p ¼ 0.013). According to the comparison of preop and postop levels, an increase in LFABP/Cr values secondary to surgical intervention was observed without any statistically significant difference. Besides the LFABP/Cr levels do not change after percutaneous kidney surgery, KIM-1/Cr, NAG/Cr, and NGAL/Cr levels increase postop period, especially at 24 h. Further studies with a larger series and repeated measurements should be performed to clarify if they can be used to demonstrate renal damage after percutaneous surgery or not.

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The Clinical Utility of Kidney Injury Molecule 1 in the Prediction, Diagnosis and Prognosis of Acute Kidney Injury: A Systematic Review

Abstract: Kim-1 is a potential novel urinary biomarker in the early detection of AKI within 24 hours after kidney insult. It might be especially beneficial in the diagnosis of ischemic ATN.

Cited by 81 publications

References 31 publications

Bupropion Cannot Reduce Acute Kidney Injury Due to Ischemia-Reperfusion

Bupropion Cannot Reduce Acute Kidney Injury Due to Ischemia-Reperfusion

Urinary kidney injury molecule-1 rapid test predicts acute kidney injury in extremely low-birth-weight neonates

Potential biomarkers for the early detection of acute kidney injury after percutaneous nephrolithotripsy

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