The clinical utility of basophil activation testing in diagnosis and monitoring of allergic disease

Hoffmann, Hans‐Jürgen; Santos, Alexandra; Mayorga, Cristobalina; Nopp, Anna; Eberlein, Bernadette; Ferrer, Marta; Rouzaire, Paul; Ebo, Didier G.; Sabato, Vito; Sánz, M L; Pecaric‐Petkovic, Tatjana; Patil, Sarita U.; Hausmann, Oliver; Shreffler, Wayne G.; Korošec, Peter; Knol, Edward F.

doi:10.1111/all.12698

Cited by 324 publications

(377 citation statements)

References 132 publications

(199 reference statements)

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“…However, 4% to 6% of patients experiencing SR following an insect sting have negative skin test results and no detectable specific IgE in serum [27]. These patients represent a diagnostic challenge, it is essential to know which venom the patient is sensitized to before immunotherapy with venoms can be prescribed.…”

Section: Systemic Reactions Due To Hymenoptera Stings With Negative Smentioning

confidence: 99%

“…This test has a diagnostic sensitivity of between 85% and 100%, with a specificity of 83% to 100%, depending on the study [27]. It has been reported that BAT is capable of diagnosing up to two-thirds of patients with SR due to stings and negative results with conventional tests [27,31].…”

Section: Systemic Reactions Due To Hymenoptera Stings With Negative Smentioning

confidence: 99%

“…The BAT, which is more expensive and more timeconsuming than other techniques, is still not fully standardized and is also activated with CCDs, although these determinants influence this technique less than they do determination of IgE to whole venom [33]. While the BAT serves to detect the existence of double sensitization better than IgE to whole venom [27,45], it is more useful in the diagnosis of SRs with negative skin and specific IgE tests.…”

Section: Multiple Sensitizations To Hymenoptera Venomsmentioning

confidence: 99%

“…These have shown significant reductions in the expression of the CD63 marker after only 6 months of treatment, that is, at an earlier stage than IgE and skin tests. In one study, the reduction in BAT was correlated with tolerance to stings after VIT was completed [27,78]. However, currently, BAT is not sufficiently standardized, and more studies are needed to establish its real usefulness in the monitoring of VIT.…”

Section: Monitoring Immunotherapy With Hymenoptera Venommentioning

confidence: 99%

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Key Issues in Hymenoptera Venom Allergy: An Update

Alfaya

Soriano-Gomis

Mera

et al. 2017

J Investig Allergol Clin Immunol

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In this review, the Hymenoptera Allergy Committee of the SEAIC analyzes the most recent scientific literature addressing problems related to the diagnosis of hymenoptera allergy and to management of venom immunotherapy. Molecular diagnosis and molecular risk profiles are the key areas addressed. The appearance of new species of hymenoptera that are potentially allergenic in Spain and the associated diagnostic and therapeutic problems are also described. Finally, we analyze the issue of mast cell activation syndrome closely related to hymenoptera allergy, which has become a new diagnostic challenge for allergists given its high prevalence in patients with venom anaphylaxis.

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Section: Systemic Reactions Due To Hymenoptera Stings With Negative Smentioning

confidence: 99%

Section: Systemic Reactions Due To Hymenoptera Stings With Negative Smentioning

confidence: 99%

Section: Multiple Sensitizations To Hymenoptera Venomsmentioning

confidence: 99%

Section: Monitoring Immunotherapy With Hymenoptera Venommentioning

confidence: 99%

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Key Issues in Hymenoptera Venom Allergy: An Update

Alfaya

Soriano-Gomis

Mera

et al. 2017

J Investig Allergol Clin Immunol

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“…The diagnosis of chronic autoimmune urticaria is made using the basophil histamine release or basophil activation tests (4). Physical urticaria is classified as late pressure urticaria, cold urticaria, heat contact urticaria, urticaria factitia and vibratory urticaria.…”

Section: Introductionmentioning

confidence: 99%

High-dose anti-histamine use and risk factors in children with urticaria

Uysal¹,

Avcıl²,

Erge³

2016

Turk Pediatri Ars

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Aim: The drugs of choice in the treatment of urticaria in children are H1-antihistamines. The aim of the study was to evaluate children with urticaria and define risk factors for requirement of high-dose H1-antihistamines in children with urticaria. Material and Methods:The medical data of children who were diagnosed as having urticaria admitted to our outpatient clinic between January 2014 and January 2016 were searched. The medical histories, concomitant atopic diseases, parental atopy histories, medications, treatment responses, blood eosinophil and basophil counts, and serum total IgE levels were recorded. In addition, the urticaria activity score for seven days, autoimmune antibody tests, and skin prick test results were evaluated in children with chronic urticaria. Results:The numbers of the children with acute and chronic urticaria were 138 and 92, respectively. The age of the children with chronic urticaria was higher than that of those with acute urticaria (p<0.0001). There was no difference between the two groups in terms of blood eosinophil and basophil counts, and serum total IgE levels (p>0.05). There was a negative correlation between blood eosinophil count and the UAS7 score in children with chronic urticaria (r=-0.276, p=0.011). Chronic urticaria and requirement of high dose H1-antihistamines were significant in children aged ≥10 years (p<0.001, p=0.015). High UAS7 score (OR: 1.09; CI 95%: [1.03-1.15]) and basopenia (OR: 6.77; CI 95%: [2.01-22.75]) were associated with the requirement of high-dose H1-AH in children with chronic urticaria. Conclusion:The requirement of high-dose H1-antihistamines was higher with children's increasing age. Disease severity and basopenia were risk factors for the requirement of high-dose H1-antihistamines. (Turk Pediatri Ars 2016; 51: 198-203)

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Food Allergy

Harrison¹,

Giovannini²,

Kalaichandran³

et al. 2020

Encyclopedia of Life Sciences

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Food allergy has recently become more common. There is no curative treatment for food allergy and management relies on allergen avoidance and emergency treatment of accidental allergic reactions. Food allergy can have a significant impact on the lives of patients and their families and an accurate diagnosis is, therefore, of utmost importance. A food allergy‐focused clinical history, together with evidence of allergen‐specific IgE, can be enough to confirm or exclude the diagnosis of food allergy; however, in the equivocal cases, exposure to the allergen in a controlled environment in hospital, called oral food challenge (OFC), is required. New tests are being developed to reduce the number of patients that need OFCs. Allergen‐specific immunotherapy has shown to reduce patients' sensitivity to the allergen but the majority of treated patients still remain food allergic. In the absence of a definitive treatment, prevention of food allergy is key. Key Concepts Food allergy prevalence is increasing, affecting about 7% of children and 2% of adults, with cow's milk, egg, peanut, tree nuts, sesame, fish and shellfish constituting more than 90% of food allergies in children. Risk factors for food allergy are atopic eczema, family history of atopic diseases, black or Asian ethnicity, less diverse diet, low serum vitamin D and filaggrin loss‐of‐function mutations. The diagnosis of food allergy is usually based on a combination of clinical history and evidence of allergen‐specific IgE, with oral food challenges being reserved for the equivocal cases. There is no curative treatment for food allergy; management consists of allergen avoidance and emergency treatment plan for accidental allergic reactions. Allergenic foods should be introduced in the diet at the time of weaning. Early peanut consumption in the first year of life can prevent the development of peanut allergy at school age.

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The clinical utility of basophil activation testing in diagnosis and monitoring of allergic disease

Cited by 324 publications

References 132 publications

Key Issues in Hymenoptera Venom Allergy: An Update

Key Issues in Hymenoptera Venom Allergy: An Update

High-dose anti-histamine use and risk factors in children with urticaria

Food Allergy

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