The Clinical Syndrome of Malaria in the United States

Heineman, Herbert S.

doi:10.1001/archinte.1972.00320040083011

Cited by 20 publications

(6 citation statements)

References 51 publications

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“…From such patients, individuals get infected through blood transfusions, transplacentally, or via mosquito bite. 2 Thus, there is a need for an increased awareness of the problems resulting from the resurgence of malaria in the United States.…”

Section: Pulmonary Complications Of Malaria Vandana Patel Md* Andmentioning

confidence: 99%

“…Diagnosis can also be made on a thin smear, with the added advantage of allowing speciation of the parasite. 2 Attempts should always be made to quantitate the percentage of parasitized cells. Mild or severe anemia, leukopenia, and thrombocytopenia are usually present.…”

Section: Diagnosismentioning

confidence: 99%

“…Often parasitized RBCs can be demonstrated in the pulmonary circulation. 2,3,16 Duarte and coworkers 17 studied the ultrastructure of the lung in a patient who died of serious respiratory distress. They found marked interstitial edema of the septa dissocating the matrix substance and fibrils.…”

Section: Autopsy Findingsmentioning

confidence: 99%

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Pulmonary Complications of Malaria

Patel¹,

Khan²

1991

Semin Respir Crit Care Med

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Section: Pulmonary Complications Of Malaria Vandana Patel Md* Andmentioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

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Pulmonary Complications of Malaria

Patel¹,

Khan²

1991

Semin Respir Crit Care Med

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“…23 Historical data indicate that once the fraction of parasitized erythrocytes exceeds 10%, the case fatality rate may be as high as 72%. [23][24][25][26][27] Whereas the destruction and removal of red blood cells is usually not immediately life-threatening, outcome is determined by profound and complex disturbances of the microcirculation that ultimately lead to hypoxia and acidosis of dependent tissues and multiorgan failure. 1,28 In this scenario, hypoxia of mucous membranes may lead to breakdown in mucosal barriers, allowing for the invasion of fungal elements in both the respiratory and alimentary tract.…”

Section: Discussionmentioning

confidence: 99%

“…Mortality of P. falciparum infection in non‐immune individuals directly correlates with the extent of parasitaemia at presentation 23 . Historical data indicate that once the fraction of parasitized erythrocytes exceeds 10%, the case fatality rate may be as high as 72% 23–27 . Whereas the destruction and removal of red blood cells is usually not immediately life‐threatening, outcome is determined by profound and complex disturbances of the microcirculation that ultimately lead to hypoxia and acidosis of dependent tissues and multiorgan failure 1,28 .…”

Section: Discussionmentioning

confidence: 99%

Minireview: invasive fungal infection complicating acute Plasmodium falciparum malaria

Däbritz

Schneider

Just-Nuebling

et al. 2009

Mycoses

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Malaria is the most important parasitic infection in people, affecting 5-10% of the world's population with more than two million deaths a year. Whereas invasive bacterial infections are not uncommon during severe Plasmodium falciparum malaria, only a few cases of opportunistic fungal infections have been reported. Here, we present a fatal case of disseminated hyalohyphomycosis associated with acute P. falciparum malaria in a non-immune traveller, review the cases reported in the literature and discuss the theoretical foundations for the increased susceptibility of non-immune individuals with severe P. falciparum malaria to opportunistic fungal infections. Apart from the availability of free iron as sequelae of massive haemolysis, tissue damage, acidosis and measures of advanced life support, patients with complicated P. falciparum malaria also are profoundly immunosuppressed by the organism's interaction with innate and adaptive host immune mechanisms.

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Transfusion-Induced Malaria

Seeler¹,

Miller²,

Lin³

et al. 1973

Am J Dis Child

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A 5-month-old infant developed malaria 16 days after cardiac surgery. After transfusion, one must consider the possibility of transfusion-induced malaria in any patient with the triad of fever, hepatosplenomegaly, and hemolysis.Although transfusion-induced ma¬ il laria is not a new disease, we feel cases should be reported to re¬ mind physicians of the danger inher¬ ent in blood transfusion. With the large number of veterans returning from parts of the world where ma¬ laria is endemic, the potential for transfusion-induced malaria steadily increases.1-7 Currently, there are some 3,000 to 4,000 cases of malaria yearly within the United States.5-7 We have recently treated a 5-month-old pa-tient who developed malaria by trans¬ fusion. This case serves to remind physicians to consider malaria in pa¬ tients who develop spiking tempera¬ tures after transfusion. Diagnosis can usually be made by careful in¬ spection of the peripheral blood films. Report of a CaseThe patient, a 5-month-old boy with a ventricular septal defect and severe pulmonic stenosis required a Waterston shunt (side-to-side anastomosis between the as¬ cending aorta and the right pulmonary ar¬ tery) because of severe cyanosis. During and after surgery, he received several small transfusions from a single unit of 3day-old blood. The postoperative course was uneventful, and the patient was dis¬ charged afebrile ten days later. On the 16th postoperative day, he began to have spiking fever and was readmitted two days later.Physical examination revealed a poorly developed, toxic child in moderate respira¬ tory distress. His temperature was 40.6 C; respiration rate, 68 breaths per minute; pulse rate, 180 beats per minute; and weight, 5.4 kg (less than third percentile). The skin was clear without petechiae, pal¬ lor, or icterus. The lungs were clear to per¬ cussion and auscultation. There was a grade 3/6 ejection murmur along the left lower sternal border, and the continuous

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The Clinical Syndrome of Malaria in the United States

Cited by 20 publications

References 51 publications

Pulmonary Complications of Malaria

Pulmonary Complications of Malaria

Minireview: invasive fungal infection complicating acute Plasmodium falciparum malaria

Transfusion-Induced Malaria

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