The Clinical Spectrum of Unruptured Intracranial Aneurysms

Intracranial arterial and arteriovenous malformations presenting with infarction. Lausanne Stroke Registry study*

“…In the latter study, aneurysm size larger than 15 mm and its location in the posterior circulation were independent risk factors associated with less favorable outcomes, whilst patients with a single aneurysm had a better outcome than those with multiple aneurysms (Orz et al, 2000). However, in aneurysms associated with IS/TIA, surgical therapy can be associated with new stroke (Wirth et al, 1983;Qureshi et al, 2000) and the mortality can range from 0% (Asari, 1992) to 6.8% (Raps et al, 1993). Thus, the treatment of unruptured aneurysms accompanied by IS/TIA should be determined by the severity of the neurological deficit caused by the ischemic event (Asari, 1992).…”

Intracranial arterial and arteriovenous malformations presenting with infarction. Lausanne Stroke Registry study*

“…In the latter study, aneurysm size larger than 15 mm and its location in the posterior circulation were independent risk factors associated with less favorable outcomes, whilst patients with a single aneurysm had a better outcome than those with multiple aneurysms (Orz et al, 2000). However, in aneurysms associated with IS/TIA, surgical therapy can be associated with new stroke (Wirth et al, 1983;Qureshi et al, 2000) and the mortality can range from 0% (Asari, 1992) to 6.8% (Raps et al, 1993). Thus, the treatment of unruptured aneurysms accompanied by IS/TIA should be determined by the severity of the neurological deficit caused by the ischemic event (Asari, 1992).…”

Headache and Treatment of Unruptured Intracranial Aneurysms

“…19,[30][31][32] Moreover, bleeding within the vascular wall may be also responsible for pain. 8 A placebo effect has also been proposed as a factor contributing to improvement 19 and cannot be completely ruled out in this group. The methodology used in this report for the evaluation of the effect of UIA treatment is routinely used to evaluate headache response to drugs and other treatment strategies.…”

Thunderclap headache

“…18 Unfortunately, not all patients in this study had CSF examinations and there were abnormal neurological findings or other clinical and imaging features which posed little diagnostic confusion as to the presence of an underlying cause for the headache. This study therefore did not address patients with thunderclap headache with normal CT, CSF, and neurological examinations.…”

Intracranial arterial and arteriovenous malformations presenting with infarction. Lausanne Stroke Registry study*

“…In the latter study, aneurysm size larger than 15 mm and its location in the posterior circulation were independent risk factors associated with less favorable outcomes, whilst patients with a single aneurysm had a better outcome than those with multiple aneurysms (Orz et al, 2000). However, in aneurysms associated with IS/TIA, surgical therapy can be associated with new stroke (Wirth et al, 1983;Qureshi et al, 2000) and the mortality can range from 0% (Asari, 1992) to 6.8% (Raps et al, 1993). Thus, the treatment of unruptured aneurysms accompanied by IS/TIA should be determined by the severity of the neurological deficit caused by the ischemic event (Asari, 1992).…”

Headache and Treatment of Unruptured Intracranial Aneurysms

“…19,[30][31][32] Moreover, bleeding within the vascular wall may be also responsible for pain. 8 A placebo effect has also been proposed as a factor contributing to improvement 19 and cannot be completely ruled out in this group. The methodology used in this report for the evaluation of the effect of UIA treatment is routinely used to evaluate headache response to drugs and other treatment strategies.…”

Thunderclap headache

“…18 Unfortunately, not all patients in this study had CSF examinations and there were abnormal neurological findings or other clinical and imaging features which posed little diagnostic confusion as to the presence of an underlying cause for the headache. This study therefore did not address patients with thunderclap headache with normal CT, CSF, and neurological examinations.…”

Intracranial arterial and arteriovenous malformations presenting with infarction. Lausanne Stroke Registry study*

“…In the latter study, aneurysm size larger than 15 mm and its location in the posterior circulation were independent risk factors associated with less favorable outcomes, whilst patients with a single aneurysm had a better outcome than those with multiple aneurysms (Orz et al, 2000). However, in aneurysms associated with IS/TIA, surgical therapy can be associated with new stroke (Wirth et al, 1983;Qureshi et al, 2000) and the mortality can range from 0% (Asari, 1992) to 6.8% (Raps et al, 1993). Thus, the treatment of unruptured aneurysms accompanied by IS/TIA should be determined by the severity of the neurological deficit caused by the ischemic event (Asari, 1992).…”

Headache and Treatment of Unruptured Intracranial Aneurysms

“…19,[30][31][32] Moreover, bleeding within the vascular wall may be also responsible for pain. 8 A placebo effect has also been proposed as a factor contributing to improvement 19 and cannot be completely ruled out in this group. The methodology used in this report for the evaluation of the effect of UIA treatment is routinely used to evaluate headache response to drugs and other treatment strategies.…”

Thunderclap headache

“…18 Unfortunately, not all patients in this study had CSF examinations and there were abnormal neurological findings or other clinical and imaging features which posed little diagnostic confusion as to the presence of an underlying cause for the headache. This study therefore did not address patients with thunderclap headache with normal CT, CSF, and neurological examinations.…”