The clinical spectrum of posthypoxic myoclonus

Frucht, Steven J.; Fahn, Stanley

doi:10.1002/mds.870150702

Cited by 101 publications

(101 citation statements)

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“…A combination of medications based on the neurotransmitter hypotheses is often needed to obtain adequate control of symptoms. Frucht and Fahn (2000) reviewed more than 100 cases of LAS and found that clonazepam, sodium valproate, and piracetam were significantly effective in approximately 50% of patients. Recently, several groups have confirmed the efficacy of levetiracetam in PHM (Frucht et al, 2001;Krauss et al, 2001;Lim and Ahmed, 2005).…”

Section: Discussionmentioning

confidence: 99%

Lance-adams syndrome: a report of two cases

Yan-Xing

Liu

Jiang

et al. 2007

J. Zhejiang Univ. - Sci. B

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Chronic post-hypoxic myoclonus, also known as Lance-Adams syndrome (LAS), is a rare complication of successful cardiopulmanry resuscitation often accompanied by action myoclonus and cerebellar ataxia. It is seen in patients who have undergone a cardiorespiratory arrest, regained consciousness afterwards, and then developed myoclonus days or weeks after the event. Worldwide, 122 cases have been reported in the literature so far, including 1 case of Chinese. Here we report 2 Chinese LAS patients with detailed neuroimagings. Cranial single photon emission computed tomography (SPECT) of patient 1, a 52-year-old woman, showed a mild hypoperfusion in her left temporal lobe, whereas patient 2, a 54-year-old woman, manifested a mild bilateral decrease of glucose metabolism in the frontal lobes and a mild to moderate decrease of the N-acetyl aspartate (NAA) peak in the bilateral hippocampi by cranial [18 F]-fluorodeoxyglucose positron emission tomographic (PET) scan and cranial magnetic resonance spectroscopy (MRS), respectively. We also review the literature on the neuroimaging, pathogenesis, and treatment of LAS.

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Section: Discussionmentioning

confidence: 99%

Lance-adams syndrome: a report of two cases

Yan-Xing

Liu

Jiang

et al. 2007

J. Zhejiang Univ. - Sci. B

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“…The etiology for seizure is cholinergic crisis and hypoxia in OPC poisoning. Myoclonus is due to hypoxia in post cardiac arrest or respiratory failure 4 . Fasciculation and tremor are due to nicotinic effect in OPC poisoning and hypoxia and muscle weakness in other condition.…”

Section: Discussionmentioning

confidence: 99%

A Study of Abnormal Movements in ICU Patients in Rajah Muthiah Medical College

Sathishkumar¹

2017

JMSCR

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Movement disorders disrupt motor function not by causing weakness but by producing either abnormal, involuntary, unwanted movements, or by curtailing the amount of normal free flowing movement. We observed all patients admitted in ICU and video recorded 30 patients with new onset abnormal movements.In our study most common involuntary movement is tremor followed by myoclonus and seizure. Most common cause of admission associated with involuntary movement is OPC poisoning followed by fever in our study. In our study post hypoxic myoclonus was associated with poor prognosis.

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“…Negative myoclonus may affect the legs and trunk, causing postural lapses and a characteristic bouncing gait [16]. [19,Class III]. They summarized the response to therapy, separating patients who experienced marked or full improvement from those who did not (Table 2).…”

Section: Posthypoxic Myoclonusmentioning

confidence: 98%

Myoclonus

Chang

Frucht

2000

Curr Treat Options Neurol

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The diagnosis and treatment of myoclonus pose a particular challenge to the neurologist. Few well-controlled double-blind studies of antimyoclonic agents have been performed, and clinical rating of the effectiveness of treatment has been primarily descriptive. As a result, therapy is often empiric. This article reviews the author's approach to treating patients with myoclonus. Three principles guide treatment. First, the cause and physiology of the myoclonic jerks must be ascertained before choosing the appropriate therapy. Second, multiple drugs often must be used in combination to achieve functional improvement. Third, given the paucity of adequately controlled trials, the treating physician must rely on well-documented case series of patients with myoclonic syndromes who obtained benefit from a drug.

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The clinical spectrum of posthypoxic myoclonus

Cited by 101 publications

References 0 publications

Lance-adams syndrome: a report of two cases

Lance-adams syndrome: a report of two cases

A Study of Abnormal Movements in ICU Patients in Rajah Muthiah Medical College

Myoclonus

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