The Clinical Spectrum of Pachydermoperiostosis (Primary Hypertrophic Osteoarthropathy)

Matucci‐Cerinic, Marco; Lotti, Torello; Jajić, Ivo; Pignone, Alberto Moggi; Bussani, Cecilia; Cagnoni, M

doi:10.1097/00005792-199105000-00005

Cited by 94 publications

(70 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In 1935, Albert Touraine, Gabriel Solente andLaurent Gole identified it as a syndrome which was separate from acromegaly and secondary hypertrophic pulmonary osteoarthropathy [2]. Three forms of PDP have been described: Complete (Pachydermia with Periostosis and clubbing), incomplete (No pachydermia) and frusteform (Prominent Pachydermia with no Periostitis) [2,3]. The exact incidence is not known.…”

Section: Discussionmentioning

confidence: 99%

Bilateral Ptosis Due to a Rare Cause-Pachydermoperiostosis

Mahadevaiah

Murthy²

2013

JCDR

View full text Add to dashboard Cite

Pachydermoperiostosis is a rare hereditary disorder that is characterised by pachydermia (thickening of the facial skin and/ or scalp), and periostosis (swelling of the periarticular tissue and a subperiosteal new bone formation). Other associated features are arthralgia, polyarthritis, clubbing, seborrhoea, hyperhidrosis, hypertrophic gastropathy, peptic ulcer and gyanecomastia. Eyelid ptosis which is caused by thickened eyelids (blepharoptosis) is a less common association. We are hereby reporting a patient with a complete form of Pachydermoperiostosis, wherein the presenting feature was bilateral ptosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Bilateral Ptosis Due to a Rare Cause-Pachydermoperiostosis

Mahadevaiah

Murthy²

2013

JCDR

View full text Add to dashboard Cite

show abstract

“…[12,18] A definitive treatment for PDP has not yet been established, but symptomatic management with NSAIDs, simple analgesics, and intravenous bisphosphonates is currently being used. [19] In addition, oral tamoxifen has been reported to be effective for arthralgia that is refractory to NSAIDs.…”

Section: Discussionmentioning

confidence: 99%

Pachydermoperiostosis Mimicking Acromegaly: A Case Report

Kwon

Joung

2012

Turk J Rheumatol

View full text Add to dashboard Cite

“…Though it closely r e s e m b l e s p u l m o n a r y h y p e r t r o p h i c osteoarthropathy, in pachydermoperiostosis no causative factors such as pulmonary, cardiac or hepatic disorders have been demonstrated. [1][2][3] Existence of the features of periostosis and cutaneous thickening along with the absence of any disease involving any other system of the body suggests PDP. The precise incidence of the disease is unknown [1][2][3] but one study has estimated prevalence of 0.16%.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3] Existence of the features of periostosis and cutaneous thickening along with the absence of any disease involving any other system of the body suggests PDP. The precise incidence of the disease is unknown [1][2][3] but one study has estimated prevalence of 0.16%. 4 It occurs predominantly and more severely in men with male: female ratio of 7-9:1.…”

Section: Introductionmentioning

confidence: 99%

Pachydermoperiostosis And An Eyelid Ptosis Associated With Spiky Keratoderma – An Unusual Presentation

Das

Chakraborty

Sarkar

2016

Nepal J Dermatol Venereol & Leprol

View full text Add to dashboard Cite

CitationChakraborty S, Sarkar NS, Das S. Pachydermoperiostosis and an eyelid ptosis associated with spiky keratoderma-an unusual presentation. NJDVL 2014; 12(1): 48 -52. AbstractPachydermoperiostosis, (PDP), a rare hereditary disorder that is characterized by digital clubbing, pachydermia, subperiosteal new bone formation, associated with pain, polyarthritis, cutis verticis gyrata, seborrhoea and hyperhidrosis. It mainly presents due to disfiguring facial features, widening of the limbs and bone and joint pain. It affects male population predominantly and transmitted as an autosomal dominant trait. There are many constant features associated with it as well as rarer features. Increased proliferation of the fibroblast and dysregulation of matrix protein play a central role in the pathogenesis of the disease. They are diagnosed primarily on clinical and radiological grounds. Histopathology plays a supportive role in the diagnosis. Such a case has to be differentiated from several other conditions like acromegaly, neurofibroma, myxedema, primary systemic amyloidosis as well as from other causes of digital clubbing. The case which is described here is a complete form of PDP which is a rare disease reported in Indian context and that too with the a rarer presentation of spiky palmoplanter keratoderma and severe mechanical ptosis leading to severe visual impairment which was corrected after surgical manipulation of the ptosis.

show abstract

The Clinical Spectrum of Pachydermoperiostosis (Primary Hypertrophic Osteoarthropathy)

Cited by 94 publications

References 0 publications

Bilateral Ptosis Due to a Rare Cause-Pachydermoperiostosis

Bilateral Ptosis Due to a Rare Cause-Pachydermoperiostosis

Pachydermoperiostosis Mimicking Acromegaly: A Case Report

Pachydermoperiostosis And An Eyelid Ptosis Associated With Spiky Keratoderma – An Unusual Presentation

Contact Info

Product

Resources

About