The clinical spectrum of human hantavirus infection in Somerset, UK

Pether, J. V. S.; Lloyd, Graham

doi:10.1017/s095026880005679x

Cited by 19 publications

(12 citation statements)

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“…This study confirmed the presence of hantavirus in the rodent population of Northern Ireland. The prevalence of infection in rodents by serology and antigen detection in our population (24 1 %) was considerably higher than that reported (I 8 %) in Great Britain [9] but is similar to that reported in serosurveys elsewhere [10]. Lack of correlation between antigen and antibody assays may represent early infection before development of antibody.…”

Section: Discussionsupporting

confidence: 77%

Evidence of hantavirus in wild rodents in Northern Ireland

et al. 1996

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A survey of evidence of rodent hantavirus infection in County Down, Northern Ireland was carried out by using immunofluorescence to detect virus antigen and antibody. Antibodies to hantavirus (R22 strain of Seoul virus and Hantaan 76-118) were found in 11/51 (21.6%) brown rats (Rattus norvegicus), 1/31 (3.2%) field mice (Apodemus sylvaticus) and 17/59 (28.8%) house mice (Mus domesticus). Seven rodents had evidence of hantavirus antigen in lung tissues. Antibody positive animals were significantly more likely to be adults than juveniles (P = 0.04) but and there was no sex difference between antibody positive and negative animals. House mice were more likely to be antibody positive if captured inside farm outbuildings (P = 0.08). Attempts to culture virus from the rodent material were unsuccessful. This work demonstrates a substantial rodent reservoir for hantavirus in Northern Ireland.

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Section: Discussionsupporting

confidence: 77%

Evidence of hantavirus in wild rodents in Northern Ireland

et al. 1996

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“…There have been reports of clinical hantaviral infections in Albania [67], Denmark [68], Luxembourg [48], Poland [69], Romania [70], Slovakia [71], Switzerland [72], the Netherlands [73] and the United Kingdom [74] (Table 2). Sero-epidemiological surveys have demonstrated human hantaviral infections in Italy [75], Latvia [76], Lithuania [77], Portugal [3], the Republic of Moldova [78], and Spain [79], though no clinical cases have been reported in these countries ( Table 2).…”

Section: Europementioning

confidence: 99%

Hantavirus Infection: a review and global update

Formenty

Roth

2008

J Infect Dev Ctries

200

215

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Hantaviruses have the potential to cause two different types of diseases in human: hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). HFRS, initially described clinically at the turn of the 20 th century, occurs endemically in the Asian and European continents, while HPS, recognized as a clinical entity since 1993, represents the prototype of emerging diseases occurring in the Western hemisphere. Approximately 150,000 to 200,000 cases of HFRS are hospitalized each year world wide, with most of the cases occurring in the developing countries. The case fatality rate of HFRS varies from <1% to 12% depending on the viruses. Although HPS is much smaller in number than HFRS, with approximately 200 HPS cases per year in the Americas, the average case fatality rate is 40%. The reported cases of hantaviral infection is increasing in many countries and new hantavirus strains have been increasingly identified worldwide, which constitutes a public health problem of increasing global concern. Hantaviral infection might be underestimated due to its asymptomatic and nonspecific mild infection, and the lack of simple standardized laboratory diagnostics in hospitals, especially in the developing countries. This review summarizes the current knowledge on virology, epidemiology, clinical manifestation, laboratory diagnostics, treatment and prevention of hantaviruses and hantaviral infections.

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“…A survey in Somerset found that hantavirus antibody was present in 4 of 100 Rattus norvegicus, 1 of 102`mice' (it is not stated whether these were Mus or Apodemus) and none of 76 C. glareolus [144]. The type speci®city of these seropositive animal sera was not reported.…”

Section: Hantaviruses In Great Britain (Gb)mentioning

confidence: 99%