The clinical spectrum of familial and sporadic idiopathic generalized epilepsy

Gesche, Joanna; Hjalgrim, Helle; Rubboli, Guido; Beier, Christoph P.

doi:10.1016/j.eplepsyres.2020.106374

Cited by 6 publications

(7 citation statements)

References 29 publications

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“…However, health care and education are free of charge in Denmark and amenable regardless of social status 44 . In addition, the similar social status of patients with EGTCS—despite similar heredity 32 —clearly argues against social background as an overseen major confounder.…”

Section: Discussionmentioning

confidence: 99%

“…In patients with persistent seizures, delineation of the subsyndromes was based on the seizure types present at inclusion 31 . Diagnosis was verified using electronic medical records as described previously 27 ; assessment of family history was described in 32 . Other clinical characteristics such as alcohol abuse were derived from the patients’ electronic medical records and were typically based on the treating physicians’ assessment of the information provided by the patient.…”

Section: Methodsmentioning

confidence: 99%

“…31 Diagnosis was verified using electronic medical records as described previously 27 ; assessment of family history was described in. 32 Other clinical characteristics such as alcohol abuse were derived from the patients' electronic medical records and were typically based on the treating physicians' assessment of the information provided by the patient. Patients were subcategorized as being seizure-free, not seizure-free, or pseudo-resistant based on the last clinical assessment stated in the medical records.…”

Section: Epilepsy-related Measuresmentioning

confidence: 99%

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Social outcome and psychiatric comorbidity of generalized epilepsies – A case‐control study

et al. 2021

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Objective: To investigate social outcome and psychiatric comorbidity of patients with idiopathic/genetic generalized epilepsies (IGEs) and its subtypes (epilepsy with generalized tonic-clonic seizures alone [EGTCS], juvenile absence epilepsy [JAE], and juvenile myoclonic epilepsy [JME]). Methods: A cohort of 402 adult patients with IGE from the Danish island Funen was matched with 4020 randomly selected geography-, age-, and sex-matched controls via the Danish Civil Registration System. Based on register data, we compared social status measured by cohabitant status, educational attainment, income, affiliation to labor market, and psychiatric comorbidity. Results: As compared to controls, patients with IGE had similar cohabitant status but fewer children (no children: 59.0% vs 50.9%), and lower educational level (primary school only: 46.0% vs 37.3%), employment rate (outside of workforce: 56.7% vs 46.5%), and income (low income: 32.6% vs 24.9%) (P < 0.001 for all comparisons). Having IGE was associated with higher a proportion of psychiatric comorbidity (IGE, 22.6%; controls, 13.0%) (P < 0.001). Seizure-free patients did not differ from controls; patients with persistent seizures had lower incomes and employment rates.In the IGE subgroup analyses, JME was associated with worse social status in all parameters studied (eg, 65.9% of JME patients were outside the workforce vs 44.5% of matched controls; P < 0.001), whereas no adverse social status was identified in patients with EGTCS and JAE. Significance: Patients with IGE in general and JME in particular have poorer social status and more psychiatric comorbidity than matched population controls without epilepsy. Poor seizure control was associated with social status and may contribute to negative socioeconomic consequences associated with IGE.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Epilepsy-related Measuresmentioning

confidence: 99%

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Social outcome and psychiatric comorbidity of generalized epilepsies – A case‐control study

et al. 2021

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“…2,3 By comparison, a family history of epilepsy has been reported in 13% to 27% of probands with idiopathic generalized epilepsy (IGE). 4,5 Decades later, we have seen tremendous growth in our understanding of the genetic basis of many epilepsy syndromes. While the genetics behind some epilepsies are so well-known that they are now listed by the genetic change, such as CDKL5 disorder, definitive understanding of the genetic cause of many childhood onset generalized epilepsy syndromes, including EMAS, is not clear.…”

Section: Commentarymentioning

confidence: 99%

“…2,3 By comparison, a family history of epilepsy has been reported in 13% to 27% of probands with idiopathic generalized epilepsy (IGE). 4,5…”

Section: Commentarymentioning

confidence: 99%

Epilepsy With Myoclonic Atonic Seizures: Why Is the Yield of Genetic Testing for a “Presumed Genetic” Epilepsy Low?

Nickels¹

2020

Epilepsy Curr

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Gene–gene interaction network analysis indicates CNTN2 is a candidate gene for idiopathic generalized epilepsy

Lin,

He,

Zhu

et al. 2024

Neurogenetics

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The clinical spectrum of familial and sporadic idiopathic generalized epilepsy

Cited by 6 publications

References 29 publications

Social outcome and psychiatric comorbidity of generalized epilepsies – A case‐control study

Social outcome and psychiatric comorbidity of generalized epilepsies – A case‐control study

Epilepsy With Myoclonic Atonic Seizures: Why Is the Yield of Genetic Testing for a “Presumed Genetic” Epilepsy Low?

Gene–gene interaction network analysis indicates CNTN2 is a candidate gene for idiopathic generalized epilepsy

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