The Clinical Spectrum of Aspergillosis–Part 2: Classification and Description of Saprophytic, Allergic, and Invasive Variants of Human Disease

Bardana, Emil J.; Silva-Hutner, Margarita

doi:10.3109/10408368009106445

Cited by 102 publications

(42 citation statements)

References 409 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many of the ear lier works citing high incidence of aspergillus precipitins did not control for false positives due to the presence of CRP. If after excluding CRP the serological test for aspergillus re mains positive, it may well be of diagnostic significance since over 80% of patients with true aspergillus infection have positive serum precipitin tests [2], In the present study no patient's scrum was positive for the cryptococcal antigen test. This is in agreement with our wider experience and with that of others [7], When this test is per formed properly it is extremely sensitive and specific, with little chance of false positivity.…”

Section: Discussionmentioning

confidence: 52%

Fungal Serology in the Elderly

Rudensky¹,

Rosin²

1984

Gerontology

View full text Add to dashboard Cite

90 geriatric patients without any clinical signs of systemic fungal infection had their sera tested for the presence of Candida and aspergillus precipitins and cryptococcal antigens. None of the patients had positive aspergillus or cryptococcal serology. 13 % of patients were found to have Candida precipitins, but these cases were not significantly correlated with Candida colonisation, length of hospitalisation, prior antibiotic therapy, steroid therapy or diabetes. Allowing for 13% false positives, serological testing might be helpful in identifying systemic candidiasis. It is probably highly specific for parenchymal involvement by aspergillus or cryptococcus.

show abstract

Section: Discussionmentioning

confidence: 52%

Fungal Serology in the Elderly

Rudensky¹,

Rosin²

1984

Gerontology

View full text Add to dashboard Cite

show abstract

“…The most important factors predisposing to colonization of the respiratory tract with aspergilli or other fungi include chronic destructive pulmonary disease, prolonged use of broad-spectrum antibiotics, malnutrition, and debilitation. A high incidence of saprophytic colonization has also been demonstrated in patients with bronchial asthma, bronchiectasis, chronic bronchitis, cystic fibrosis, and primary ciliary dyskinesia syndrome (19,20). Some of these patients mount an immunologic response manifested by serum precipitins, immediate skin reactivity, and an Arthus skin reaction to Aspergillus antigen.…”

Section: Characteristic Features Of Aspergillus-induced Diseasesmentioning

confidence: 99%

“…Because of its simplicity and ease of performance, immunodiffusion (ID) is still the most widely used technique for the serodiagnosis of aspergillosis. Several investigators have highlighted its usefulness in demonstrating precipitin arcs in agar gels as a diagnostic tool for aspergillosis (18,19,40,113,122,123,136,140,170,239). Antigens used in ID may be extracts from mycelia or culture filtrates, which should be free of C-reactive substance (136).…”

Section: Humoral Immune Responsementioning

confidence: 99%

Immunodiagnosis of aspergillosis

1991

View full text Add to dashboard Cite

Aspergillus species are ubiquitous fungi and have been implicated as the causative agents of a variety of lung disorders in humans. These disorders include allergic, saprophytic, and systemic manifestations. The allergic disorders mainly affect atopic persons, and invasive or systemic diseases affect immunosuppressed individuals. Immunodiagnosis can help the practitioner diagnose these diseases. Demonstration of circulating antibodies is a useful criterion, but the lack of dependable and standardized antigens is a limiting factor in the diagnosis of most Aspergillus-induced diseases. Despite this limitation, however, immunodiffusion and enzyme-linked immunosorbent assays have been widely used for the detection of antibodies in the sera of patients with aspergillosis. Similarly, crude and semipurified antigens are being used to demonstrate skin hypersensitivity in patients, and several methods have been useful in the detection of antigenemia in patients with invasive aspergillosis. With a growing number of reports on the incidence of aspergillosis and an increase in the number of immunosuppressed individuals in the population, more rapid methods and more reliable reagents for immunodiagnosis are needed. With recent attempts at obtaining reliable reagents for through hybridoma technology and molecular biological techniques, substantial progress toward efficient immunodiagnosis may be achieved.

show abstract

“…Pathogenic species of Aspergillus, particularly Aspergillus fumigatus, are the causative agents of a variety of pulmonary diseases in human including invasive aspergillosis, allergic bronchopulmonary aspergillosis and aspergilloma to mention a few (1). Invasive aspergillosis is difficult to diagnose and successful treatment depends on the early detection of the fungus (2).…”

Section: Introductionmentioning

confidence: 99%