The clinical spectrum of aspergillosis in chronic obstructive pulmonary disease

Otu, Akaninyene; Kosmidis, Chris; Mathioudakis, Alexander G.; Ibe, Chibuike; Denning, David W.

doi:10.1007/s15010-022-01960-2

Cited by 10 publications

(19 citation statements)

References 150 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1 In recent years, it has become an increasingly important global public health concern. 1,2 As per the recommendations by the European Confederation of Medical Mycology (ECMM), indicators for monitoring CPA include imaging assessment, culture from respiratory samples, and serology on Aspergillus-specific IgG. 3 Some studies, on the other hand, suggested only a weak correlation between serology finding and CPA treatment.…”

Section: Introductionmentioning

confidence: 99%

“…Chronic pulmonary aspergillosis (CPA) is a progressive respiratory syndrome predominantly affecting individuals who are immunocompetent or subtly immunocompromised, particularly those with underlying structural lung diseases, most notably post‐treatment tuberculosis (TB) 1 . In recent years, it has become an increasingly important global public health concern 1,2 . As per the recommendations by the European Confederation of Medical Mycology (ECMM), indicators for monitoring CPA include imaging assessment, culture from respiratory samples, and serology on Aspergillus ‐specific IgG 3 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chronic pulmonary Aspergillosis in a patient with poorly controlled diabetes: A case report and literatures review

Chuang,

2024

Respirology Case Reports

View full text Add to dashboard Cite

Chronic pulmonary aspergillosis (CPA) often manifests in patients with a history of pulmonary tuberculosis and is typically characterized by recurrent hemoptysis, weight loss, and frequently coexists with poorly controlled diabetes. While weight gain is acknowledged as a valuable clinical marker for monitoring therapeutic responses in CPA, there is a scarcity of case reports exploring this aspect. Furthermore, the impact of stringent blood sugar management in diminishing CPA activity and preventing the recurrence of hemoptysis is also underreported. In this context, we present the case of a 64‐year‐old male who experienced massive hemoptysis. He had a background of uncontrolled diabetes and a history of fully treated pulmonary tuberculosis. Following therapeutic embolization, he was diagnosed with CPA that had transformed into invasive pulmonary aspergillosis (IPA) and underwent antifungal therapy for 9 months. Notably, we observed an inverse correlation between the patient's improved blood sugar control and weight gain with the serum IgG levels for Aspergillosis. This case highlights the potential benefits of non‐invasive monitoring of CPA activity and the identification of treatment responders through effective blood sugar management and weight gain.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chronic pulmonary Aspergillosis in a patient with poorly controlled diabetes: A case report and literatures review

Chuang,

2024

Respirology Case Reports

View full text Add to dashboard Cite

show abstract

“…Early diagnosis and identification of factors predisposing to pulmonary aspergillosis are therefore critical to reduce mortality from fungal infections. 4 Ascaris spp. induce immunological and structural changes in the lungs during larval migration owing to the switch to Th2 from Th1 response.…”

Section: Introductionmentioning

confidence: 99%

“…Early diagnosis and identification of factors predisposing to pulmonary aspergillosis are therefore critical to reduce mortality from fungal infections. 4…”

Section: Introductionmentioning

confidence: 99%

Impact of Ascaris lumbricoides infection on the development of chronic pulmonary aspergillosis in patients with COPD

Toychiev,

Gafner,

Belotserkovets

et al. 2024

Trop Doct

View full text Add to dashboard Cite

The aetiopathogenesis of chronic obstructive pulmonary disease (COPD) remains unclear. The aim of our study was to determine the possible influence of Ascaris lumbricoides on the development of chronic pulmonary aspergillosis (CPA) in patients with COPD. The prevalence of A. lumbricoides in patients with COPD with CPA (19.05%) was significantly higher than that in those without (9.20%) and controls (4.9%) ( p < 0.05). Trends in levels of Interleukin-1β and of tumour necrosis factor α suggest ascariasis increases susceptibility to Aspergillus sp. in patients with COPD and can be considered an additional risk factor for CPA.

show abstract

“…A study in 2017 reported global estimates of 3,000,000 cases of chronic pulmonary aspergillosis, and ~ 250,000 cases of invasive aspergillosis [4]. The immunocompromised hosts, such as those with haematological malignancies, solid organ transplants, and chronic lung diseases, and those exposed to environmental triggers such as dust and mould, are disproportionately affected by aspergillosis [5].…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and antifungal susceptibilities of clinically isolated Aspergillus species in South China

Bilal,

Zhang,

Shafiq

et al. 2023

Epidemiol. Infect.

View full text Add to dashboard Cite

Aspergillosis is a rising concern worldwide; however, its prevalence is not well documented in China. This retrospective study determined Aspergillus’s epidemiology and antifungal susceptibilities at Meizhou People’s Hospital, South China. From 2017 to 2022, the demographic, clinical, and laboratory data about aspergillosis were collected from the hospital’s records and analysed using descriptive statistics, chi-square test, and ANOVA. Of 474 aspergillosis cases, A. fumigatus (75.32%) was the most common, followed by A. niger (9.92%), A. flavus (8.86%), and A. terreus (5.91%). A 5.94-fold increase in aspergillosis occurred during the study duration, with the highest cases reported from the intensive care unit (52.74%) – chronic pulmonary aspergillosis (79.1%) and isolated from sputum (62.93%). Only 38 (8.02%) patients used immunosuppressant drugs, while gastroenteritis (5.7%), haematologic malignancy (4.22%), and cardiovascular disease (4.22%) were the most prevalent underlying illnesses. In A. fumigatus, the wild-type (WT) isolates against amphotericin B (99.1%) were higher than triazoles (97–98%), whereas, in non-fumigatus Aspergillus species, the triazole (95–100%) WT proportion was greater than amphotericin B (91–95%). Additionally, there were significantly fewer WT A. fumigatus isolates for itraconazole and posaconazole in outpatients than inpatients. These findings may aid in better understanding and management of aspergillosis in the region.

show abstract

The clinical spectrum of aspergillosis in chronic obstructive pulmonary disease

Cited by 10 publications

References 150 publications

Chronic pulmonary Aspergillosis in a patient with poorly controlled diabetes: A case report and literatures review

Chronic pulmonary Aspergillosis in a patient with poorly controlled diabetes: A case report and literatures review

Impact of Ascaris lumbricoides infection on the development of chronic pulmonary aspergillosis in patients with COPD

Epidemiology and antifungal susceptibilities of clinically isolated Aspergillus species in South China

Contact Info

Product

Resources

About