The Clinical Significance of Vesicoureteral Reflux

Belman, A. Barry

doi:10.1016/s0031-3955(16)33355-7

Cited by 8 publications

(6 citation statements)

References 55 publications

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“…The pathogenesis of this reflux nephropathy is thought to be due to a number of factors, such as repeated hydrodynamic changes on renal pelvis (refluxing papillary ducts) and infection, induced by vesicoureteral, intrarenal and tubuloglomerular backflow, as well as renal scarring thus reducing renal mass, and subsequently causing hyperfiltration (17)(18)(19)(20)(21)(22). Histopathological findings have been focussed on the interstitial changes.…”

Section: Discussionmentioning

confidence: 99%

Studies on Reflux Nephropathy - I. A New Model of Focal Glomerular Sclerosis

Koiso¹,

Kikuchi²,

Kôyama³

1990

Aktuel Urol

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Section: Discussionmentioning

confidence: 99%

Studies on Reflux Nephropathy - I. A New Model of Focal Glomerular Sclerosis

Koiso¹,

Kikuchi²,

Kôyama³

1990

Aktuel Urol

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“…The normal ureterovesical junction works on a socalled 'flap-valve' mechanism which permits the flow of urine from the ureter into the bladder, but prevents its return in the opposite direction [8]. The integrity of this valve-like arrangement is dependent upon a number of factors: rejection.…”

Section: Causes Of Refluxmentioning

confidence: 99%

“…The subject of whether urinary tract infection in and of itself can cause VUR is a matter of considerable con troversy. It has been postulated that infection can pro duce edema of the intramural portion of the ureter, resulting in rigidity of the ureterovesical junction and incompetence of the flap-valve [2,8,10]. Studies in the dog have confirmed that urinary infection can cause reflux [19].…”

Section: Integrity O F the Bladder Wall Musculaturementioning

confidence: 99%

“…Studies in the dog have confirmed that urinary infection can cause reflux [19]. Moreover, reflux has been shown to disappear in patients with VUR and urinary tract infection follow ing adequate treatment of the infection [20,21], It is unclear, however, whether isolated or intermittent uri nary tract infections can result in permanent distortion of the ureterovesical junction and produce persistent VUR [8,20],…”

Section: Integrity O F the Bladder Wall Musculaturementioning

confidence: 99%

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Vesicoureteral Reflux and Reflux Nephropathy

Senekjian

Suki

1982

Am J Nephrol

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Vesicoureteral reflux is an anatomic abnormality, mostly affecting a pediatric population, which may be the second leading cause of end-stage renal failure. Most cases of reflux are due to abnormalities in the insertion of the ureters into the bladder, either congenital or acquired. Most commonly, VUR is discovered during routine evaluation of urinary tract infections, but may also be present in patients with severe hypertension or chronic renal failure. The diagnosis is confirmed radiologically, utilizing either voiding cinecystography or radioisotopic methods. VUR can result in renal failure through scarring secondary to ‘chronic pyelonephritis’ or through a glomerulopathy, possibly immune in origin. In most series, the glomerulopathy is felt to be the cause of the end-stage renal failure. Treatment of VUR includes conservative (medical) management with the hope that maturation of the ureterovesical junction will cure reflux. Surgical therapy is reserved for those patients in whom this maturation is not expected to occur or in those whose urinary infections cannot be controlled. In those patients who have developed the glomerulopathy secondary to VUR, surgery may not halt the progression of the renal disease. VUR in a transplanted kidney may result in a higher risk of loss of the graft due to glomerulopathy or chronic rejection.

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“…Τα κατερχόμενα ούρα αθροίζονται στον παρακυστικό ουρητήρα και προωθούνται με περιοταλτικά κύματα. Ο ενδοκυστικός ουρητήρας δια ουρητηρική πίεση που είναι υψηλότερη της ενδοκυστικής (Belman 1976, Tanagho 1978.…”

Section: χρονολογιαunclassified

Συμβολη Στη Μελετη Των Μετεγχειρητικων Επιπλοκων Της Κυστεο-Ουρηθρο- Νεφρικης Παλινδρομησης

Κωστη-Μαντση¹

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The Clinical Significance of Vesicoureteral Reflux

Cited by 8 publications

References 55 publications

Studies on Reflux Nephropathy - I. A New Model of Focal Glomerular Sclerosis

Studies on Reflux Nephropathy - I. A New Model of Focal Glomerular Sclerosis

Vesicoureteral Reflux and Reflux Nephropathy

Συμβολη Στη Μελετη Των Μετεγχειρητικων Επιπλοκων Της Κυστεο-Ουρηθρο- Νεφρικης Παλινδρομησης

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