The Clinical Significance of RMI2 in Hepatocellular Carcinoma

Abstract

Background: Hepatocellular carcinoma (HCC), which is the most common type of primary liver cancer, often presents at advanced stage with a dismal prognosis. Novel tumor biomarkers are needed to aid in HCC early detection and prognostication. Methods: Immunohistochemical staining for RecQ-mediated genome instability protein 2 (RMI2) was performed in 330 surgically resected HCC specimens and 190 adjacent normal tissues. Univariate and multivariate regression analysis were applied to identify prognostic indicators of HCC outcomes. Patient's survival was assessed with the Kaplan–Meier method. Results: RMI2 in HCC tissue was significantly higher than that in adjacent normal tissues, and was positively correlated with HCC histological grade and stage ( P < .05) but negatively correlated with the survival period. RIM2 was identified to be an independent prognostic indicator for HCC. Conclusion: The abnormal expression of RMI2 may be related to the occurrence and development of HCC. RIM2 could potentially serve as a novel tumor-specific biomarker for HCC diagnosis and prognosis prediction.

Objective to identify and verify the regulatory mechanism of DTNBP1 as a prognostic marker for hepatocellular carcinoma

“…Lai et al demonstrated that GRPEL2 is highly expressed in the HCC and plays well in predicting OS in patients with the same gender, age, pathological grade or clinical stage 29 . CDT1 and RMI2 are also reported to be overexpressed in HCC and act as independent predictors for OS in HCC patient 30 , 31 . We suggest using TNM stage, DTNBP1, GRPEL2,CDT1, and RMI2 to form a predicting nomogram, which should be more accurate and credible.…”