The clinical significance of equivocal findings on spinal MRI in children with medulloblastoma

Bennett, Julie; Ashmawy, Ramy; Ramaswamy, Vijay; Stephens, Derek; Bouffet, Éric; Laperrière, Normand; Taylor, Michael D.; Shroff, Manohar; Bartels, Ute

doi:10.1002/pbc.26472

Cited by 9 publications

(4 citation statements)

References 14 publications

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“…In this issue of Pediatric Blood & Cancer , Bennett et al. report on the significance of equivocal spine magnetic resonance imaging (MRI) findings in children with medulloblastoma at the time of diagnosis . Cauda equina nerve root enhancement, nerve root clumping, and linear vascular enhancement are occasionally described in radiology reports and may generate uncertainty regarding clinical management and risk stratification.…”

mentioning

confidence: 99%

Magnetic resonance imaging to diagnose leptomeningeal spread of medulloblastoma in children: Decreasing diagnostic uncertainty, moving in new directions

Soares

Poretti

Huisman

2017

Pediatric Blood & Cancer

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mentioning

confidence: 99%

Magnetic resonance imaging to diagnose leptomeningeal spread of medulloblastoma in children: Decreasing diagnostic uncertainty, moving in new directions

Soares

Poretti

Huisman

2017

Pediatric Blood & Cancer

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“…Metastasis of medulloblastoma occurs in one-third of patients at diagnosis and in two-thirds at the time of relapse. Furthermore, the presence of metastasis is the strongest predictor of mortality among MB patients [89]. MS-based proteomics has been used to investigate the metastasis of MB [89].…”

Section: Drug Resistance In Childhood Cancersmentioning

confidence: 99%

“…Furthermore, the presence of metastasis is the strongest predictor of mortality among MB patients [89]. MS-based proteomics has been used to investigate the metastasis of MB [89]. Mass spectrometry imaging (MSI) using matrix-assisted laser desorption ionization (MALDI).…”

Section: Drug Resistance In Childhood Cancersmentioning

confidence: 99%

Mass Spectrometry-Based Proteomics: Analyses Related to Drug-Resistance and Disease Biomarkers

Agostini,

Traldi,

Hamdan

2023

Medicina

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Mass spectrometry-based proteomics is a key player in research efforts to characterize aberrant epigenetic alterations, including histone post-translational modifications and DNA methylation. Data generated by this approach complements and enrich datasets generated by genomic, epigenetic and transcriptomics approaches. These combined datasets can provide much-needed information on various mechanisms responsible for drug resistance, the discovery and validation of potential biomarkers for different diseases, the identification of signaling pathways, and genes and enzymes to be targeted by future therapies. The increasing use of high-resolution, high-accuracy mass spectrometers combined with more refined protein labeling and enrichment procedures enhanced the role of this approach in the investigation of these epigenetic modifications. In this review, we discuss recent MS-based studies, which are contributing to current research efforts to understand certain mechanisms behind drug resistance to therapy. We also discuss how these MS-based analyses are contributing to biomarkers discovery and validation.

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“…These features are commonly encountered in SHH medulloblastomas and represent the sequelae of posttreatment inflammatory changes rather than recurrence or metastasis. Awareness of these equivocal findings on serial images is essential to obviate the need for more aggressive therapy (139,140).…”

Section: Role Of Imagingmentioning

confidence: 99%

Pediatric Brain Tumor Genetics: What Radiologists Need to Know

et al. 2018

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Brain tumors are the most common solid tumors in the pediatric population. Pediatric neuro-oncology has changed tremendously during the past decade owing to ongoing genomic advances. The diagnosis, prognosis, and treatment of pediatric brain tumors are now highly reliant on the genetic profile and histopathologic features of the tumor rather than the histopathologic features alone, which previously were the reference standard. The clinical information expected to be gleaned from radiologic interpretations also has evolved. Imaging is now expected to not only lead to a relevant short differential diagnosis but in certain instances also aid in predicting the specific tumor and subtype and possibly the prognosis. These processes fall under the umbrella of radiogenomics. Therefore, to continue to actively participate in patient care and/or radiogenomic research, it is important that radiologists have a basic understanding of the molecular mechanisms of common pediatric central nervous system tumors. The genetic features of pediatric low-grade gliomas, high-grade gliomas, medulloblastomas, and ependymomas are reviewed; differences between pediatric and adult gliomas are highlighted; and the critical oncogenic pathways of each tumor group are described. The role of the mitogen-activated protein kinase pathway in pediatric low-grade gliomas and of histone mutations as epigenetic regulators in pediatric high-grade gliomas is emphasized. In addition, the oncogenic drivers responsible for medulloblastoma, the classification of ependymomas, and the associated imaging correlations and clinical implications are discussed. © RSNA, 2018 • Abbreviations: CDK = cyclin-dependent kinase, CNS = central nervous system, DIPG = diffuse intrinsic pontine glioma, FGFR1 = fibroblast growth factor receptor 1, GBM = glioblastoma multiforme, HGG = high-grade glioma, IDH = isocitrate dehydrogenase, IDH1 = IDH 1, LGG = low-grade glioma, MAPK = mitogenactivated protein kinase, MEK = MAPK/extracellular signal-regulated kinase (ERK) kinase, PXA = pleomorphic xanthoastrocytoma, SHH = sonic hedgehog, SUFU = suppressor of fused, WHO = World Health Organization, Wnt = wingless RadioGraphics 2018; 38:2102-2122

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The clinical significance of equivocal findings on spinal MRI in children with medulloblastoma

Abstract: A higher proportion of equivocal findings was identified in the SHH subgroup. This institutional retrospective review demonstrates equivocal findings are common, not associated with decreased OS and should not prompt increased dose of CSI.

Cited by 9 publications

References 14 publications

Magnetic resonance imaging to diagnose leptomeningeal spread of medulloblastoma in children: Decreasing diagnostic uncertainty, moving in new directions

Magnetic resonance imaging to diagnose leptomeningeal spread of medulloblastoma in children: Decreasing diagnostic uncertainty, moving in new directions

Mass Spectrometry-Based Proteomics: Analyses Related to Drug-Resistance and Disease Biomarkers

Pediatric Brain Tumor Genetics: What Radiologists Need to Know

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