The clinical significance of congenital Agenesis of the Corpus Callosum

Abstract

Three cases of congenital agenesis of the corpus callosum (ACC) are presented along with typical clinical features observed on computerized tomography and magnetic resonance imaging. Most congenital ACC cases do not display hemi-syndromes or callosal syndromes, but do exhibit some deficit in terms of hemispheric integration. The most common neuropsychological impairments are in the areas of motor and perceptual-motor functioning. Clinical guidelines in the assessment of ACC patients are given.

Morphology of acallosal brains as assessed by MRI in six patients leading a normal daily life

“…The diagnosis of ACC is predominantly made during childhood, since the majority of patients show delayed development, are mentally retarded and suffer from psychiatric and phy-sical ailments [6,[20][21][22]. In contrast, an isolated and especially a symptomless ACC was considered to be an even rarer condition, diagnosed postmortem [12,20,22] or incidentally by computed tomography (CT) [6,9] or magnetic resonance imaging (MRI) [1,2,4]. For example, 31 of 68 cases with developmental anomalies of the brain were diagnosed in a large MRI unit during 20 months as also having abnormalities of the corpus callosum (CC).…”