The clinical significance of anticentromere antibodies(ACA) in sera of patients with autoimmune liver diseases.

Clinical characteristics of patients with autoimmune hepatitis seropositive for anticentromere antibody

“…Sjögren's syndrome, autoimmune thyroiditis and incomplete type of CREST syndrome are commonly concurrent autoimmune diseases in patients with AIH seropositive for ACA (Table 2). It is of interest that these autoimmune diseases are frequently concomitant in patients with PBC 5,6 or HCV‐related CLD 12 seropositive for ACA, and that none of the AIH patients with ACA in the present study had concomitant RA (Table 2). The reason for higher frequency of concomitant autoimmune disease in AIH patients with ACA remains uncertain.…”

“…As shown in Figure 1, we revealed the prevalence of ACA in Japanese patients with type 1 AIH, which was approximately the same as that reported previously. 6,9 On the other hand, the prevalence of ACA in white patients with type 1 AIH was extremely rare. 5,10 The reason for the lower prevalence of ACA in white patients with AIH may be due to a racial difference.…”

“…In the field of liver diseases, ACA is commonly observed in patients with primary biliary cirrhosis (PBC) 4–6 . Patients with PBC seropositive for ACA often seem to develop portal hypertension 7 or liver failure 8 .…”

“…3 In the field of liver diseases, ACA is commonly observed in patients with primary biliary cirrhosis (PBC). [4][5][6] Patients with PBC seropositive for ACA often seem to develop portal hypertension 7 or liver failure. 8 ACA is occasionally found in the sera of patients with type 1 autoimmune hepatitis (AIH) 2,5,6,9,10 or even in the sera of patients with hepatitis C virus (HCV)-related chronic liver disease (CLD).…”

“…[4][5][6] Patients with PBC seropositive for ACA often seem to develop portal hypertension 7 or liver failure. 8 ACA is occasionally found in the sera of patients with type 1 autoimmune hepatitis (AIH) 2,5,6,9,10 or even in the sera of patients with hepatitis C virus (HCV)-related chronic liver disease (CLD). 11,12 We have previously shown that patients with AIH seropositive for ACA are likely to have milder liver damage and a more favorable prognosis.…”