The Clinical Significance of Alterations in Transaminase Activities of Serum and Other Body Fluids

Wróblewski, Felix

doi:10.1016/s0065-2423(08)60362-5

Cited by 109 publications

(45 citation statements)

References 74 publications

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“…The aminotransferases, however, are not confined to the liver. Their production outside of the liver has been observed as far back as the 1950s, 6 and they are found in the heart, kidneys, erythrocytes, and skeletal muscle, among other places. This gives them the potential to suggest pathology related to any cell that contains them (see Table 2).…”

Section: Discussionmentioning

confidence: 99%

Elevated Liver Enzymes Indicating a Diagnosis of Limb-Girdle Muscular Dystrophy

Lash

Kraemer

2014

J GEN INTERN MED

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Section: Discussionmentioning

confidence: 99%

Elevated Liver Enzymes Indicating a Diagnosis of Limb-Girdle Muscular Dystrophy

Lash

Kraemer

2014

J GEN INTERN MED

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“…19,20 Both aminotransferases are highly concentrated in the liver. AST is also diffusely represented in the heart, skeletal muscle, kidneys, brain and red blood cells, and ALT has low concentrations in skeletal muscle and kidney; 21 an increase in ALT serum levels is, therefore, more specific for liver damage. In the liver, ALT is localized solely in the cellular cytoplasm, whereas AST is both cytosolic (20% of total activity) and mitochondrial (80% of total activity).…”

Section: Hepatocellular Predominancementioning

confidence: 99%

Liver enzyme alteration: a guide for clinicians

Giannini

Testa

Savarino

2005

Canadian Medical Association Journal

1,480

1,017

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ISOLATED ALTERATIONS OF BIOCHEMICAL MARKERS OF LIVER DAMAGE in a seemingly healthy patient can present a challenge for the clinician. In this review we provide a guide to interpreting alterations to liver enzyme levels. The functional anatomy of the liver and pathophysiology of liver enzyme alteration are briefly reviewed. Using a schematic approach that classifies enzyme alterations as predominantly hepatocellular or predominantly cholestatic, we review abnormal enzymatic activity within the 2 subgroups, the most common causes of enzyme alteration and suggested initial investigations.

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“…Consequently, the averaged PL/TG ratio was 4.6. Increased values of serum glutamic-oxaloacetic transaminase (Wroblewski 1958, Babson et al 1962 were noticed only in this case among 16 intoxication cases. In 4 moderately affected cases, the PL/TG ratio was an average of 4.9 with range from 4.1 to 5.8.…”

Section: Resultsmentioning

confidence: 55%