The clinical response to treatment in adult Cushing's syndrome following remission of hypercortisolaemia

Ross, E. J.; Linch, David C.

doi:10.1136/pgmj.61.713.205

Cited by 24 publications

(15 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Significant differences between groups were determined by the Mann-Whitney test (a-a to e-e) and by the confidence intervals for the difference (A-A to G-G, Figure 1A, demonstrable by the common static blood pressure measurements, contribute to the observations (17,18) that the removal of hypercortisolism per se does not result in improved survival.…”

Section: Discussionmentioning

confidence: 99%

Daily blood pressure profile in Cushing's syndrome before and after surgery

Kréze¹,

Mikulecký

1999

Braz J Med Biol Res

View full text Add to dashboard Cite

No significant difference has been demonstrated in the altered circadian blood pressure pattern between the pituitary-dependent and adrenal forms of Cushings syndrome before surgery. The effect of therapy, however, proved to be different. The mesor was normalized in the pituitary-dependent Cushings syndrome more conspicuously for systolic than for diastolic blood pressure. In Cushings syndrome due to adrenal adenoma, systolic and diastolic blood pressure mesors have been even significantly overnormalized after treatment, being 11 to 27 and 2 to 13 mmHg (95% confidence) lower than corresponding mesors in controls. There was no difference between forms in the effect of treatment on blood pressure amplitudes, which remained significantly lower than in controls. Finally, acrophase patterns were partly normalized after treatment of the pituitary-dependent form only for diastolic blood pressure, while both systolic and diastolic blood pressure acrophases were normalized in the treated adrenal form. In conclusion, complete normalization of the pattern of daily blood pressure profile has not been achieved in either form of the syndrome. This may be one of the reasons for the reduced long-term survival after surgical cure of hypercortisolism, than expected.

show abstract

Section: Discussionmentioning

confidence: 99%

Daily blood pressure profile in Cushing's syndrome before and after surgery

Kréze¹,

Mikulecký

1999

Braz J Med Biol Res

View full text Add to dashboard Cite

show abstract

“…Ñèòóàö³ÿ çì³íèëàñÿ ïî÷èíàþ÷è ç 40-õ ðîê³â ìèíóëîãî ñòî-ð³÷÷ÿ, êîëè âïåðøå áóëî ñèíòåçîâàíî ãîðìîíè êîðè ÍÇ [5,12,26]. Êë³í³öèñòàìè áóëî ðîçðîá-ëåíî ÷èñëåíí³ ñõåìè çàì³ñíî¿ òåðàï³¿ ãëþêîêîð-òèêî¿äàìè äëÿ õâîðèõ ³ç ð³çíèìè ôîðìàìè ãîñ-òðî¿ òà õðîí³÷íî¿ íàäíèðêîâî¿ íåäîñòàòíîñò³ [12,16,[27][28][29][30].…”

Section: комбінована ксенотрансплантація як метод пролонгації життєздunclassified

“…Ñë³ä çàçíà÷èòè, ùî ëåòàëüí³ñòü ñåðåä õâîðèõ íà ïîñòàäðåíàëåêòîì³÷íèé ã³ïîêîðòèöèçì ó â³ääà-ëåíèé ïåð³îä íàâ³òü çà óìîâ àäåêâàòíî¿ çàì³ñ-íî¿ òåðàï³¿ ó 3-4 ðàçè âèùà, í³ae ó çàãàëüí³é ïîïóëÿö³¿. Ïðè÷èíîþ ñìåðò³ õâîðèõ ó 70-80% âè-ïàäê³â º ñåðöåâî-ñóäèíí³ ïîðóøåííÿ [14,28,29,51,56].…”

Section: комбінована ксенотрансплантація як метод пролонгації життєздunclassified

“…Àëå ó íèçö³ âèïàäê³â òðàíñïëàíòàö³ÿ íå çàáåçïå÷óâà-ëà ñòàíó åâêîðòèöèçìó, ³ õâîð³ ïîòðåáóâàëè ââå-äåííÿ åêçîãåííèõ êîðòèêîñòåðî¿ä³â [29,96].…”

Section: комбінована ксенотрансплантація як метод пролонгації життєздunclassified

“…Ó ö³ëîìó ñë³ä â³äçíà÷èòè, ùî, çà äàíèìè áà-ãàòüîõ àâòîð³â [29,97], ñòàí ã³ïîêîðòèöèçìó ó õâîðèõ ï³ñëÿ òðàíñïëàíòàö³¿ êîðè ÍÇ ïîð³âíÿíî ç³ ñòàíäàðòíîþ çàì³ñíîþ òåðàï³ºþ ñóïðîâîäaeó-âàâñÿ ñòàá³ëüíîþ êîìïåíñàö³ºþ, ïîçèòèâíèì ïñèõîåìîö³éíèì ñòàòóñîì ïàö³ºíòà, çíèaeåííÿì ðèçèêó âèíèêíåííÿ óñêëàäíåíü ³ äîñèòü íåçíà÷-íîþ ÷àñòîòîþ ðîçâèòêó êðèç³â íàäíèðêîâî¿ íå-äîñòàòíîñò³.…”

Section: комбінована ксенотрансплантація як метод пролонгації життєздunclassified

See 2 more Smart Citations

Combined xenotransplantation as a method of prolonging the viability and function of the graft in the treatment of various forms of hypocorticism

Ларін¹,

Анастасій²,

Гирявенко³

et al. 2013

CE&ES

View full text Add to dashboard Cite

Severe respiratory failure secondary to Cushing’s myopathy

Blanco

Marazuela

Flores

et al. 2001

J Endocrinol Invest

View full text Add to dashboard Cite

We report a 55-year-old woman with typical clinical, biochemical and radiological features of Cushing's disease, who developed a severe respiratory insufficiency as the main symptom. She also complained of proximal muscle weakness over the last year and progressive dyspnea over the last four months. Bronchospasm, respiratory infection or cardiologic dysfunction were excluded. Arterial blood gas analysis showed severe respiratory insufficiency with hypoxemia and hypercapnia, respiratory acidosis and a normal alveolar-arterial oxygen gradient. Spirometry and plethysmography showed a restrictive ventilatory failure and maximum inspiratory and expiratory pressures were reduced. These findings were strongly suggestive of neuromuscular disease. Serum creatine kinase, aldolase, sodium, potassium and thyroid function tests were normal. An electromyogram and a muscle biopsy confirmed myopathic disease. Ketoconazole therapy improved her symptoms and respiratory function tests. In conclusion although proximal myopathy is a frequent presenting symptom of Cushing's syndrome, involvement of respiratory muscles with severe restrictive ventilatory dysfunction has not been previously reported as the main initial feature of Cushing's disease. Medical treatment of hypercortisolism improves muscle strength and resolves the respiratory insufficiency.

show abstract

The clinical response to treatment in adult Cushing's syndrome following remission of hypercortisolaemia

Cited by 24 publications

References 18 publications

Daily blood pressure profile in Cushing's syndrome before and after surgery

Daily blood pressure profile in Cushing's syndrome before and after surgery

Combined xenotransplantation as a method of prolonging the viability and function of the graft in the treatment of various forms of hypocorticism

Severe respiratory failure secondary to Cushing’s myopathy

Contact Info

Product

Resources

About