The clinical relevance of the anti‐inflammatory properties of antihistamines

Efficacy and safety of rupatadine for allergic rhino-conjunctivitis: a systematic review of randomized, double-blind, placebo-controlled studies with meta-analysis

“…Nasal stuffiness, a bothersome and refractory symptom, was relieved in over 500 patients receiving the active drug. The action of rupatadine on allergic inflammation and activity on nasal PAF receptors was previously demonstrated as particularly pronounced 45 . This clinical evidence shows the potent antiallergic and antiinflammatory properties that distinguish rupatadine from other antihistamines, which have been documented in in-vitro and in-vivo studies 8 .…”

Levocetirizine better protects than desloratadine in a nasal provocation with allergen

“…42 In vivo, in nasal challenges with allergen, the IL-4 increase was absent or low and unaffected by a 7-day pretreatment with fexofenadine. 43,44 An increase in IL-5, IL-8, eotaxin, and ECP levels was generally reported.…”

Cetirizine and levocetirizine inhibit eotaxin‐induced eosinophil transendothelial migration through human dermal or lung microvascular endothelial cells

“…Cetirizine has well‐documented anti‐inflammatory effects both in vitro and in vivo [15, 16], including the inhibition of PAF‐dependent eosinophil chemotaxis and adhesion of eosinophils to HUVEC [17]. We therefore investigated the potential inhibitory effects of levocetirizine and cetirizine on spontaneous and eotaxin‐induced eosinophil TEM through human microvascular endothelial cells of dermal and pulmonary origin.…”