The clinical prognostic factors of patients with stage IB lung adenocarcinoma

Sui, Qihai; Liang, Jiaqi; Hu, Zhengyang; Xu, Xinming; Chen, Zhencong; Huang, Yiwei; Zhao, Mengnan; Zhan, Cheng; Wang, Lin; Zhang, Lin; Wang, Qun

doi:10.21037/tcr-21-1174

Cited by 4 publications

(4 citation statements)

References 36 publications

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“…The rapid growth of pSD compared to pGGO aligns with previous findings. Sui Q et al analyzed 7605 patients with adenocarcinoma from the SEER (Surveillance, Epidemiology, and End Results) database and concluded that female sex and age ≤ 60 years are independent prognostic factors for better survival, supporting these findings 29 . These results were also confirmed by a larger study involving 61,928 patients conducted by Wu Y et al 30 .…”

Section: Discussionmentioning

confidence: 93%

Correlation of CT features of lung adenocarcinoma with sex and age

Yang,

Gao,

et al. 2024

Sci Rep

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This study aimed to retrospectively examine the computed tomography (CT) features of lung adenocarcinoma across different demographic groups. Preoperative chest CT findings from 1266 surgically resected lung adenocarcinoma cases were retrospectively analyzed. Lung adenocarcinomas were categorized based on CT characteristics into pure ground glass (pGGO), nodule-containing ground glass opacity (mGGO), and pure solid without containing ground glass opacity (pSD). These categories were correlated with sex, age, EGFR status, and five histopathological subtypes. The diameters of pGGO, mGGO, and pSD significantly increased across all patient groups (P < 0.05). Males exhibited a significantly higher proportion of pSD than females (P = 0.002). The mean diameters of pGGO and pSD were significantly larger in males than in females (P = 0.0017 and P = 0.043, respectively). The frequency of pGGO was higher in the younger age group (≤ 60 years) compared to the older group (> 60 years) for both males (P = 0.002) and females (P = 0.027). The frequency of pSD was higher in the older age group for both sexes. A linear correlation between age and diameter was observed in the entire cohort as well as in the male and female groups (P < 0.0001 for all groups). EGFR mutations were less frequent in pSD compared to pGGO (P = 0.0002) and mGGO (P < 0.0001). The frequency of lesions containing micropapillary components increased from pGGO to mGGO and pSD (P < 0.0001 for all). The frequency of lesions containing solid components also increased from pGGO to mGGO and pSD (P = 0.045, P < 0.0001, and P < 0.0001, respectively). The CT features of lung adenocarcinoma exhibit differences across genders and age groups. Male gender and older age are risk factors for lung adenocarcinoma growth.

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Section: Discussionmentioning

confidence: 93%

Correlation of CT features of lung adenocarcinoma with sex and age

Yang,

Gao,

et al. 2024

Sci Rep

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“…Some scholars have identified risk factors influencing postoperative recurrence and have constructed predictive models for recurrence, aiming to inform the selection of ACT for stage IB NSCLC patients (91)(92)(93)(94)(95)(96). However, relatively limited research has been conducted on predictive models for postoperative recurrence in patients with stage IB NSCLC featuring VPI.…”

Section: Stage Ib and Adjuvant Chemotherapymentioning

confidence: 99%

Diagnosis, treatment, and prognosis of stage IB non-small cell lung cancer with visceral pleural invasion

Ruan,

Zhuo,

2024

Front. Oncol.

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With the increasing implementation of early lung cancer screening and the increasing emphasis on physical examinations, the early-stage lung cancer detection rate continues to rise. Visceral pleural invasion (VPI), which denotes the tumor’s breach of the elastic layer or reaching the surface of the visceral pleura, stands as a pivotal factor that impacts the prognosis of patients with non-small cell lung cancer (NSCLC) and directly influences the pathological staging of early-stage cases. According to the latest 9th edition of the TNM staging system for NSCLC, even when the tumor diameter is less than 3 cm, the final T stage remains T2a if VPI is present. There is considerable controversy within the guidelines regarding treatment options for stage IB NSCLC, especially among patients exhibiting VPI. Moreover, the precise determination of VPI is important in guiding treatment selection and prognostic evaluation in individuals with NSCLC. This article aims to provide a comprehensive review of the current status and advancements in studies pertaining to stage IB NSCLC accompanied by VPI.

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“…Studies have reported age, race, sex, cancer location, pathologic type, airway spread through air space, and TNM staging as prognostic factors for lung cancer ( 1 – 5 ). Nodule features on thin-section CT images, especially nodule consistency that describes the appearance of a lung nodule, have also been proved to be important prognostic factors for lung adenocarcinoma.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Prognosis in Patients with Lung Adenocarcinoma with Atypical Solid Nodules on Thin-Section CT Images

Liu,

Yang,

Sun

et al. 2024

Radiology: Cardiothoracic Imaging

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Purpose To evaluate the clinicopathologic characteristics and prognosis of patients with clinical stage IA lung adenocarcinoma with atypical solid nodules (ASNs) on thin-section CT images. Materials and Methods Data from patients with clinical stage IA lung adenocarcinoma who underwent resection between January 2005 and December 2012 were retrospectively reviewed. According to their manifestations on thin-section CT images, nodules were classified as ASNs, subsolid nodules (SSNs), and typical solid nodules (TSNs). The clinicopathologic characteristics of the ASNs were investigated, and the differences across the three groups were analyzed. The Kaplan-Meier method and multivariable Cox analysis were used to evaluate survival differences among patients with ASNs, SSNs, and TSNs. Results Of the 254 patients (median age, 58 years [IQR, 53–66]; 152 women) evaluated, 49 had ASNs, 123 had SSNs, and 82 had TSNs. Compared with patients with SSNs, those with ASNs were more likely to have nonsmall adenocarcinoma ( P < .001), advanced-stage adenocarcinoma ( P = .004), nonlepidic growth adenocarcinoma ( P < .001), and middle- or low-grade differentiation tumors ( P < .001). Compared with patients with TSNs, those with ASNs were more likely to have no lymph node involvement ( P = .009) and epidermal growth factor receptor mutation positivity ( P = .018). Average disease-free survival in patients with ASNs was significantly longer than that in patients with TSNs ( P < .001) but was not distinguishable from that in patients with SSNs ( P = .051). Conclusion ASNs were associated with better clinical outcomes than TSNs in patients with clinical stage IA lung adenocarcinoma. Keywords: Adenocarcinoma, Atypical Solid Nodules, CT, Disease-free Survival, Lung, Prognosis, Pulmonary Supplemental material is available for this article . Published under a CC BY 4.0 license.

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The clinical prognostic factors of patients with stage IB lung adenocarcinoma

Cited by 4 publications

References 36 publications

Correlation of CT features of lung adenocarcinoma with sex and age

Correlation of CT features of lung adenocarcinoma with sex and age

Diagnosis, treatment, and prognosis of stage IB non-small cell lung cancer with visceral pleural invasion

Evaluation of Prognosis in Patients with Lung Adenocarcinoma with Atypical Solid Nodules on Thin-Section CT Images

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