The clinical importance of emerging Campylobacter species

Man, Si Ming

doi:10.1038/nrgastro.2011.191

Cited by 401 publications

(393 citation statements)

References 207 publications

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“…In addition, cytokines associated with carcinogenesis (eg IL‐18) were more highly expressed in the tissues colonized by Campylobacter 55. Given the potential human pathogenicity of Campylobacter species (which has been recently recognized),56 the role of Campylobacter in esophageal adenocarcinoma progression might mimic that of Helicobacter pylori in gastric cancer.…”

Section: Microbiome and Esophageal Adenocarcinomamentioning

confidence: 99%

Review of the gut microbiome and esophageal cancer: Pathogenesis and potential clinical implications

Baba

Iwatsuki

Yoshida

et al. 2017

Annals of Gastroent Surgery

100

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Esophageal cancer ranks among the most aggressive malignant diseases. The limited improvements in treatment outcomes provided by conventional therapies have prompted us to seek innovative strategies for treating this cancer. More than 100 trillion microorganisms inhabit the human intestinal tract and play a crucial role in health and disease conditions, including cancer. The human intestinal microbiome is thought to influence tumor development and progression in the gastrointestinal tract by various mechanisms. For example, Fusobacterium nucleatum, which primarily inhabits the oral cavity and causes periodontal disease, might contribute to aggressive tumor behavior through activation of chemokines such as CCL20 in esophageal cancer tissue. Composition of the intestinal microbiota is influenced by diet, lifestyle, antibiotics, and pro‐ and prebiotics. Therefore, by better understanding how the bacterial microbiota contributes to esophageal carcinogenesis, we might develop novel cancer prevention and treatment strategies through targeting the gastrointestinal microflora. This review discusses the current knowledge, available data and information on the relationship of microbiota with esophagitis, Barrett's esophagus, esophageal adenocarcinoma and squamous cell carcinoma.

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Section: Microbiome and Esophageal Adenocarcinomamentioning

confidence: 99%

Review of the gut microbiome and esophageal cancer: Pathogenesis and potential clinical implications

Baba

Iwatsuki

Yoshida

et al. 2017

Annals of Gastroent Surgery

100

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“…de Campylobacter posteriormente a infeção intestinal (Blaser et al, 1986;Selander, 1993;Butzler, 2004;Man, 2011). As sequelas mais relevantes incluem a síndrome de Guillan-Barré, síndrome de Miller-Fisher, síndrome de Reyter´s e a síndrome Hemolítico-urêmica (Gillespie et al, 2002).…”

Section: Manifestações Clínicas E Patogêneseunclassified

“…O processo é mediado por anticorpos autoimune contra a bainha de mielina do sistema nervoso periférico (Overell;Willison, 2005 (Man, 2011).…”

Section: Manifestações Clínicas E Patogêneseunclassified

“…Dessa maneira, a bactéria causa danos ao DNA da célula hospedeira e promove a interrupção do ciclo celular. Outras toxinas, como por exemplo a hemolisina, também podem ser produzidas durante o processo de bacteremia promovendo a lise dos eritrócitos (Man, 2011). …”

Section: Manifestações Clínicas E Patogêneseunclassified

“…Outra toxina descrita para algumas espécies de Campylobacter é a hemolisina, que possui a capacidade de promover a lise dos eritrócitos (Man, 2011).…”

Section: Genes Relacionados à Virulênciaunclassified

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Caracterização molecular de linhagens de Campylobacter coli isoladas de origens diversas

Gomes¹

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Este espaço é dedicado àqueles que, de alguma forma, contribuíram para que esta dissertação fosse realizada. Não sendo viável nomeá-los a todos, há no entanto alguns a quem não posso deixar de manifestar o meu apreço e agradecimento sincero.Á Deus pela benção da vida, proteção e força para superar os obstáculos ao longo da minha jornada.À Profª Drª Juliana Pfrimer Falcão, pela orientação, pelo carinhoso apoio, partilha do saber e as valiosas contribuições para a realização desse trabalho. Acima de tudo, obrigada por continuar a acompanhar-me nesta jornada e por estimular o meu interesse pelo conhecimento. Agradeço pela confiança em mim depositada, pelo empenho, paciência e o exemplo profissional e moral durante todo esse período. Minha profunda admiração. Muito Obrigada por tudo! Á minha querida e amada Mãe pelo amor sem reservas, pelos momentos de carinho e por tornar a minha vida mais colorida. Ao meu Pai pela figura firme e segura que me empurra nos momentos mais difíceis, por tornar possível os meus sonhos e conquistas. Não tenho palavras para descrever esse Amor! Aos meus queridos irmãos Gabriela, Marcos, Carina e ao meu sobrinho João Vitor pelo incentivo, apoio e carinho. Vocês são parte de mim! Á aquele que não leva jeito com as palavras, mas tem um abraço que me acalma, um olhar que me alegra, um sorriso que conforta e um amor que me transforma. Alessandro, "Não me lembro mais qual foi nosso começo. Sei que não começamos pelo começo. Já era amor antes de ser"! strains; the flhA gene was detected in 11 (17.5%) strains; the dnaJ gene was detected in 10 (15.9%) strains; the pldA gene was detected in 7 (11.1%) strains ; the iamA gene was detected in three (4.8%) strains; the cdtC and docA genes were found in two (3.2%) strains; the cdtA and crsA were found in one (1.6%) strain and the ciaB, wlaN, virB11 and racR genes were not detected. Among the 63 strains studied, 42 were susceptible to all antimicrobials tested. Of the 21 resistant strains, 10 (15.9%) were resistante to tetracycline and doxaciclyne, six (9.5%) showed resistance to ciprofloxacin, and one (1.6%) was resistant to erythromycin. Only four (6.3%) strains were simultaneously resistant to at least two different classes of the antibiotics tested. The dendrogram of genetic similarity of Pulsed field gel electrophoresis (PFGE) grouped the 63 strains studied into two groups namely PFGE-A and PFGE-B with a genomic similarity of 44.9% among them. However, some strains isolated from humans, animals, the environment and food presented a high genotypic similarity above 80% and were subdivided into seven groups designated as PFGE-A1 to PFGE-A7. The dendrogram of genetic similarity of the SRV-flaA gene sequences grouped the strains studied into two groups namely SVR-A and SVR-B, with similarity above 83.1% among them. Besides, the deposit of the SVR sequences of the flaA gene in the online database showed that the alleles 30 and 1647 were the iv most frequently found and allowed the comparison between the strains studied with the alleles described in the d...

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Gram‐negative rods

2015

Practical Medical Microbiology for Clinicians

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The clinical importance of emerging Campylobacter species

Cited by 401 publications

References 207 publications

Review of the gut microbiome and esophageal cancer: Pathogenesis and potential clinical implications

Review of the gut microbiome and esophageal cancer: Pathogenesis and potential clinical implications

Caracterização molecular de linhagens de Campylobacter coli isoladas de origens diversas

Gram‐negative rods

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