The Clinical Impact of Immediate On-Site Cytopathology Evaluation During Endoscopic Ultrasound-Guided Fine Needle Aspiration of Pancreatic Masses: A Prospective Multicenter Randomized Controlled Trial

Abstract

Results of this study demonstrated no significant difference in the diagnostic yield of malignancy, proportion of inadequate specimens, and accuracy in patients with pancreatic mass undergoing EUS-FNA with or without OCE.

Endoscopic ultrasound guided fine‐needle aspiration: What variables influence diagnostic yield?

“…A recent study by Wani et al demonstrated that the immediate on‐site cytopathology evaluation might not be absolutely vital during EUS–FNA of pancreatic masses. Although this study revealed comparable diagnostic yield and inadequate specimen during EUS–FNA with and without ROSE, the on‐site evaluation group required fewer passes as compared to the EUS–FNA without on‐site evaluation.…”

State-of-the-art endoscopic procedures for pancreatic cancer

“…10.2217/fon-2016-0123 review Coronel & Waxman future science group 241 patients with solid pancreatic lesions showed that the use of immediate OCE does lead to fewer needle passes (OCE = 4 vs no OCE = 7; p < 0.0001), but does not improve the diagnostic yield of malignancy and proportion of specimen adequacy. In addition, the use of immediate OCE did not affect overall procedure time, adverse events rates, number of repeat procedures, cost and sample quality [37].…”

Advancing the diagnostic and therapeutic role of EUS in pancreaticobiliary disease: Hopkins Lecture 2016

“…This was one of the first studies to challenge the conventional wisdom of the utility of ROSE. A recent randomised controlled trial arrived at the same conclusion 7. ROSE may however have a role during training and in centres with a low adequacy rate 8.…”