The clinical impact of epilepsy genetics

Johnson, Michael R.

doi:10.1136/jnnp.70.4.428

Cited by 24 publications

(7 citation statements)

References 37 publications

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“…These have helped but not contributed much toward understanding the basic mechanisms of human epileptogenesis. Conversely, epilepsies with predominantly a complex genetic predisposition are common and account for ∼50% of all genetically based epilepsies (8).…”

Section: Some Recent Advances In Genetics Of Human Epilepsiesmentioning

confidence: 99%

Genetics in Epilepsy: Transcultural Perspectives

Tripathi

Jain

2003

Epilepsia

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Summary:In the last two decades there have been many significant advances with regard to the genetics of human epilepsies. Knowledge of the mutations responsible for inherited human epilepsies not only will help in a better diagnosis and understanding of the mechanisms involved in epileptogenesis and their inheritance, but also will result in the development of better and safer antiepileptic drugs, discovery of novel therapeutic modalities, improved genetic counseling, and perhaps even prevention of epilepsies. The overall impact of these genetic discoveries across different populations and cultures will perhaps be beneficial to improving the lives of the millions affected by these diverse but common brain disorders.

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Section: Some Recent Advances In Genetics Of Human Epilepsiesmentioning

confidence: 99%

Genetics in Epilepsy: Transcultural Perspectives

Tripathi

Jain

2003

Epilepsia

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“…In addition, a family history of epilepsy seems to enhance the risk of epilepsy (Bitterncoourt et al, 1999). For epilepsy resulting from parasitic infections, the interaction between parasitic agents, social economic status, genetics and environmental factors determines the magnitude of developing epilepsy (Johnson & Sander, 2001). In general, in subSaharan Africa, the aetiology of epilepsy is multifactorial and may include different agents such as helminths and protozoans.…”

Section: Epidemiology Of Epilepsy and Parasitic Infections In Sub-sahmentioning

confidence: 99%

Epilepsy and tropical parasitic infections in Sub-Saharan Africa: a review

Mazigo

Morona

Kweka

et al. 2013

Tanzania J Hlth Res

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Several reports have suggested that the high prevalence of epilepsy in sub-Saharan Africa is associated with the high prevalence of parasitic infections affecting the central nervous system. Though epidemiological evidence suggests an association between parasitic infections and epilepsy, the biological causal relationship has not been fully demonstrated for many of these infections. The objective of this paper is to review the available epidemiological evidence on the links between parasitic infections and epilepsy, the pathogenesis and the current gap of knowledge indicating the areas requiring further research. Data for this review were identified and collected using manual and electronic search strategies of published and unpublished sources. In Sub-Saharan Africa, the epidemiology of epilepsy remains unclear and given the differing study designs, the results of available epidemiological studies are difficult to interpret and compare. Evidence from surveys reported a median prevalence of 1.5%. Co-infection of parasitic infections and epilepsy in sub-Saharan Africa are common, particularly in areas characterized by poor hygiene standards. There is an epidemiological link on the association between epilepsy and various parasitic infections. However, the biological causal relationship requires further investigation in adequately designed studies. In conclusion, although several epidemiological and case control studies indicate a relationship between parasitic agents and epilepsy in sub-Saharan Africa, there is a considerable gap of knowledge on the cause and magnitude of the association. Thus, there is an urgent need for systematic epidemiological studies to understand the burden of epilepsy in areas endemic due to preventable parasitic infections, to prove a causal relationship, and to understand the impact of controlling these parasitic diseases on reduction of the burden of epilepsy.___________________________________________________________________________________

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“…It is has been suggested that endemic infections are the main reason for the increased incidence of epilepsy in developing countries in conjunction with other factors, such as environmental and social factors (e.g. tropical climate, ecological niches, poor sanitation, malnutrition, inadequate health delivery systems) (4, 6, 14).…”

Section: Endemic Infectionsmentioning

confidence: 99%

Epilepsy and comorbidity: infections and antimicrobials usage in relation to epilepsy management

Sander

Perucca

2003

Acta Neurologica Scandinavica

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Infections are probably the most common preventable cause of epilepsy worldwide. There are concerns that endemic infections and infestations, such as malaria and neurocysticercosis, could be responsible for the increased incidence of epilepsy in the developing world. Cases of epilepsy associated with neurocysticercosis are also being seen increasingly in developed countries due to migration from, and travel to, endemic areas. When prescribing antimicrobial agents in patients with epilepsy a number of issues need to be considered, such as potential adverse effects on seizure control and interactions with concomitant antiepileptic drugs (AEDs). Some antimicrobial agents, including penicillins, cephalosporins, carbapenems, quinolones and antimalarials, can have proconvulsant activity and may precipitate seizures, even in patients who do not have epilepsy. Moreover, many antimicrobials increase or decrease the plasma levels of AEDs, whereas some AEDs may adversely affect the efficacy of antimicrobials.

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The clinical impact of epilepsy genetics

Cited by 24 publications

References 37 publications

Genetics in Epilepsy: Transcultural Perspectives

Genetics in Epilepsy: Transcultural Perspectives

Epilepsy and tropical parasitic infections in Sub-Saharan Africa: a review

Epilepsy and comorbidity: infections and antimicrobials usage in relation to epilepsy management

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