The clinical impact of [18F]FDG PET/CT for the management of recurrent endometrial cancer: correlation with clinical and histological findings

Chung, Hyun Hoon; Kang, Won Jun; Kim, Jae Weon; Park, Noh-Hyun; Song, Yong Sang; Chung, June‐Key; Kang, Soon‐Beom

doi:10.1007/s00259-007-0687-8

Cited by 65 publications

(30 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most patients are diagnosed at early-stage disease with the overall 5-year survival rates of 84% [1]. Positron emission tomography/computed tomography (PET/CT) utilizing [ 18 F]fluorodeoxyglucose ( 18 F-FDG) has been recommended for the diagnosis, staging, therapy monitoring, prediction of prognosis, and detection of recurrence in endometrial cancer [3,4,5]. …”

Section: Introductionmentioning

confidence: 99%

Correlation between Expression of Biological Markers and [<sup>18</sup>F]Fluorodeoxyglucose Uptake in Endometrial Cancer

Choi

Suh

et al. 2014

Oncol Res Treat

View full text Add to dashboard Cite

Purpose: Positron emission tomography/computer tomography (PET/CT) utilizing [¹⁸F]fluorodeoxyglucose (¹⁸F-FDG) has been recommended for the diagnosis, staging, therapy monitoring, prediction of prognosis, and detection of recurrence in endometrial cancer. We aimed to define the correlations of biological markers with ¹⁸F-FDG uptake in endometrial cancer. Methods: 29 patients (55 ± 8.93 years) with endometrial cancer were included in this study. All patients underwent hysterectomy and bilateral salpingo-oophorectomy with or without para-aortic lymphadenectomy at the department of Obstetrics and Gynecology of Pusan National University Hospital. Immunohistochemical studies were performed for glucose transporter 1 (GLUT-1), hexokinase II (HK-II), hypoxia-inducible factor 1α (HIF-1α), vascular endothelial growth factor (VEGF) and carbonic anhydrase IX (CA-IX). Results: There were positive correlations between FDG uptake and GLUT-1 (r = 0.375, p = 0.0452), and HK-II (r = 0.537, p = 0.0027). However, HIF-1α (r = 0.153, p = 0.4283), VEGF (r = -0,101, p = 0.6032) and CA-IX (r = 0.240, p = 0.2105) were not significantly associated with FDG uptake. No significant correlations were found among the expression levels of biological markers. Conclusion: FDG uptake in endometrial cancer was significantly associated with GLUT-1 and HK-II, while HIF-1α, VEGF and CA-IX were not associated with FDG uptake. No significant correlations were found among the expression levels of biological markers.

show abstract

Section: Introductionmentioning

confidence: 99%

Correlation between Expression of Biological Markers and [<sup>18</sup>F]Fluorodeoxyglucose Uptake in Endometrial Cancer

Choi

Suh

et al. 2014

Oncol Res Treat

View full text Add to dashboard Cite

show abstract

“…They showed that pre-operatively, PET/CT detected lymph node metastasis with 69% sensitivity and 90% specificity. According to other studies for the detection of recurrent disease, 80,81 PET/CT had excellent performance with 100% sensitivity and 83-100% specificity. The use of PET/CT has been shown to detect recurrences even in asymptomatic women with 100% sensitivity and specificity, 81 and can provide important prognostic information for women after primary treatment.…”

Section: Positron Emission Tomography/computed Tomography (Pet/ct)mentioning

confidence: 84%

“…79 PET/CT provides the synergistic benefits of morphologic and molecular imaging because of localization of increased FDG uptake with anatomical specificity. 80 Substantial evidence has now emerged documenting the role of PET/CT in the management of uterine corpus cancer patients, at the pre-operative evaluation as well as at the posttreatment surveillance (Table 6). 32,80,81 Park et al 32 performed a retrospective comparison of surgical staging with PET/CT in 53 uterine corpus cancer patients.…”

Section: Positron Emission Tomography/computed Tomography (Pet/ct)mentioning

confidence: 99%

“…80 Substantial evidence has now emerged documenting the role of PET/CT in the management of uterine corpus cancer patients, at the pre-operative evaluation as well as at the posttreatment surveillance (Table 6). 32,80,81 Park et al 32 performed a retrospective comparison of surgical staging with PET/CT in 53 uterine corpus cancer patients. They showed that pre-operatively, PET/CT detected lymph node metastasis with 69% sensitivity and 90% specificity.…”

Section: Positron Emission Tomography/computed Tomography (Pet/ct)mentioning

confidence: 99%

See 1 more Smart Citation

Current status in the management of uterine corpus cancer in Korea

Jeong

Lee

2010

J Gynecol Oncol

View full text Add to dashboard Cite

Uterine corpus cancer has increased in prevalence in Korean women over the last decade. Recently, elegant studies have been reported from many institutes. To improve treatment strategies, a review of our own data is warranted. This work will discuss the risks and prognostic factors for uterine corpus cancer, and the radiologic evaluation, prediction of lymph node metastasis, systematic lymphadenectomy, minimally invasive surgery, ovarian-saving surgery, fertility-sparing treatment, and adjuvant treatment in women with uterine cancer.

show abstract

“…According to Chung et al [16], PET/CT in detection of recurrent endometrial ca has an accuracy of 92.3 %, and allowed changing treatment modality in 22.6 % patients. In our study, a case of operated ca vulva, on follow-up, showed CT scan of recurrence in lung but PET-CT was normal, allowing changing further modality.…”

Section: Carcinoma Endometriummentioning

confidence: 99%

Role of PET–CT Scan in Gynaeconcology

Pawar

Patil

Patel

et al. 2015

J Obstet Gynecol India

View full text Add to dashboard Cite

The purpose of this study This study was undertaken to evaluate the role of positron emission tomography-CT (PET-CT) in diagnosis and management of gynecological malignancies in primary and recurrent settings and also to investigate its role in inappropriately treated patients, for pretreatment evaluation (staging) to help in proper therapeutic management. Method This is a retrospective study of 56 patients of gynecological malignancy registered in Gujarat Cancer Research Institute from June 2011 to December 2013. Results Out of 56 cases where PET was done, the results were as follows: carcinoma cervix-23, carcinoma ovary-20, carcinoma endometrium-9, carcinoma vulva-1, carcinoma vagina-2, and GTN-1. PET scan was negative in 37 % of patients where CT scan was suspicious, which changed the therapeutic modality and prevented further unnecessary interventions. In cases where clinical suspicion of recurrence was high based on rising tumor marker and CT scan was negative, subsequent PET-CT was able to pick up malignancy in 75 % cases. Eleven patients (25 %) with suspected recurrence with inconclusive CT scan and negative PET-CT scan were kept on follow-up, thus reducing further morbidity and cost. Conclusion Addition of PET-CT, a noninvasive method to the oncologist's imaging armamentarium may ultimately improve both outcomes and costs by altering management strategies in primary and recurrent settings. The potential use of PET-CT appears promising in several decisionmaking steps in the management of patients with gynecological malignancy. It defines the extent of metastatic disease which enables the clinician to decide regarding salvageable surgical intervention or palliative measures.

show abstract

The clinical impact of [18F]FDG PET/CT for the management of recurrent endometrial cancer: correlation with clinical and histological findings

Abstract: Integrated PET/CT appears to be highly sensitive, specific, and accurate as a post-therapy surveillance modality for endometrial cancer in well-selected patients. The PET/CT might be used to improve patient surveillance and prognosis.

Cited by 65 publications

References 34 publications

Correlation between Expression of Biological Markers and [<sup>18</sup>F]Fluorodeoxyglucose Uptake in Endometrial Cancer

Correlation between Expression of Biological Markers and [<sup>18</sup>F]Fluorodeoxyglucose Uptake in Endometrial Cancer

Current status in the management of uterine corpus cancer in Korea

Role of PET–CT Scan in Gynaeconcology

Contact Info

Product

Resources

About