The Clinical Impact and Long-Term Outcome of Tricuspid Regurgitation in Patients with Orthotopic Heart Transplantation

“…The result from our study is consistent with other series. Veen and associates in their larger series found that 33% of the patients had moderate to severe TR after transplant, and it declined to 15% after 5 years; however, mortality was significantly higher in patients with moderate to severe TR [ 11 ]. Bishawi and coworkers found that survival is significantly decreased in patients with moderate and severe tricuspid regurgitation after adjusting for recipient pulmonary vascular resistance, donor and recipient creatinine, ischemia time, donor age, sex mismatch, and body mass index [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

Tricuspid Valve Regurgitation After Heart Transplantation: A Single-Center 10-Year Experience

Algarni¹,

Arafat²,

Pragliola³

et al. 2020

Journal of the Saudi Heart Association

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Background Tricuspid valve regurgitation may affect the outcomes after heart transplantation. There is a paucity of data reporting the outcomes of heart transplants in our region. The objectives of this study were to report the occurrence of tricuspid regurgitation after heart transplantation, its course, and its effect on survival. Methods From 2009 to 2019, 30 patients had heart transplantation at our cardiac center. Their age was 36.73 ± 13.5 years, and 25 (83.33%) were males. Indications for transplantation were dilated cardiomyopathy (n = 21; 72.41%), ischemic cardiomyopathy (n = 8; 26.67%) and hypertrophic cardiomyopathy (n = 1; 3.45%). Cardiopulmonary bypass time was 157.24 ± 34.6 min, and ischemic time was 138 ± 73.56 min. All patients had orthotopic heart transplantation with a bi-caval technique. Results Eleven patients had severe tricuspid regurgitation postoperatively (37%). The degree of tricuspid regurgitation decreased significantly after 6 months (p = 0.011) and remained stationary during the follow-up. Pre-transplant dilated cardiomyopathy was significantly associated with severe tricuspid regurgitation post-transplant (p = 0.017). The mean follow-up was 39.43 ± 50.57 months. Survival at 10 years was 90% in patients with less than moderate tricuspid regurgitation postoperatively compared to 43% for patients with moderate and severe tricuspid regurgitation (log-rank p = 0.0498). Conclusion Tricuspid regurgitation is a common problem after heart transplantation. Despite the improvement of the degree of tricuspid regurgitation after 6 months, survival was negatively affected by postoperative moderate or severe tricuspid regurgitation. Patients with dilated cardiomyopathy may benefit from concomitant tricuspid valve repair at the time of heart transplantation. Further larger studies are warranted.

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The Clinical Impact and Long-Term Outcome of Tricuspid Regurgitation in Patients with Orthotopic Heart Transplantation

Cited by 2 publications

References 0 publications

Management of severe tricuspid valve regurgitation due to ruptured papillary muscle in a patient with mediastinitis early after heart transplant

Management of severe tricuspid valve regurgitation due to ruptured papillary muscle in a patient with mediastinitis early after heart transplant

Tricuspid Valve Regurgitation After Heart Transplantation: A Single-Center 10-Year Experience

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