The clinical, humanistic, and economic burden of palmoplantar pustulosis: a structured review

Abstract

Introduction: Palmoplantar pustulosis (PPP) is a chronic, relapsing and refractory disease characterized by sterile pustules appearing on the palms and/or soles, accompanied by erythema, blistering, scales and/or keratinization. The overall burden of PPP in terms of its clinical impact, effect on patients and families, and economic consequences has not previously been investigated in a structured manner. Areas covered: A structured search focused on identification of studies in PPP using specific search terms in PubMed and EMBASE® from 2005 onwards, with additional back-referencing and pragmatic searches. Outcomes of interest included clinical burden, humanistic burden, and economic burden. Expert opinion: In cross-sectional studies, approximately 75% of all PPP patients suffer from active disease, with risk of relapse remaining constant over time. Patients' health-related quality of life is significantly impaired, as expected for a disease affecting hands and feet. Tools have been described that assess the clinical as well as patient-reported burden of PPP; their performance in larger cohorts and/or clinical trials remains to be investigated. The key data limitations identified include inconsistent definitions for characterizing remission/relapse, and limited humanistic and economic burden data; future studies are required to address these evidence gaps.ARTICLE HISTORY (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. disease over time, including risk factors, clinical outcomes, and comorbidities); (2) Humanistic burden (functioning, quality of life [QoL], psychosocial burden, adherence/preference/satisfaction with treatment and caregiver burden); and (3) Economic burden (drivers of resource use and cost, actual costs and utilities). In the sister publication published in the same edition [2], the burden of disease of GPP is characterized in a similar way.

Pustular Psoriasis: A Narrative Review of Recent Developments in Pathophysiology and Therapeutic Options

“…Pustular Psoriasis: PPP PPP is the most common variant of pustular psoriasis; it has a reported prevalence of 0.05-0.12% and is significantly more prevalent in Japan than in Western countries [8,9]. PPP is a chronic, refractory disease that is associated with major impairment of health-related quality of life, resulting from pain and pruritus [10].…”

Generalized pustular psoriasis in Brazil: A public claims database study

“…4 , 5 , 21 The most frequent cause of admission for these patients was infection, as described in previous articles, which indicates that early and precise identification of GPP and its complications is necessary, especially in patients who require hospitalization. 26 …”

The clinical, humanistic, and economic burden of generalized pustular psoriasis: a structured review

“…The objective of the current review was, therefore, to characterize the overall disease burden of GPP across the following domains: (1) Clinical burden (epidemiology, core clinical features, and natural history of disease over time, including risk factors, clinical outcomes, and comorbidities); (2) Humanistic burden (functioning, quality of life [QoL], psychosocial burden, adherence/preference/satisfaction with treatment and caregiver burden); and (3) Economic burden (drivers of resource use and cost, actual costs, and utilities). In the sister publication published in the same edition [13], the burden of disease of PPP is characterized in a similar way.…”