The clinical, haematological and morphological profile of patients with myelodysplastic syndromes: A single institution experience from Turkey

Abstract

In a retrospective analysis of 113 patients with primary myelodysplastic syndromes (MDS) diagnosed according to French-American-British (FAB) classification, we evaluated the prognostic impact of FAB and World Health Organisation (WHO) classifications, International Prognostic Scoring System (IPSS), and other clinical and laboratory variables. The median age was 69. IPSS could be applied to 75 patients classified according to the FAB criteria and to 50 patients reclassified according to the WHO criteria. At a median follow-up of 24 months, 22 patients (19.5 %) transformed to acute myelogenous leukaemia (AML). Overall survival (OS) of patients differed significantly between the FAB and WHO subgroups (p < 0.0001). In WHO classification, significant differences were observed in both OS and leukaemia free survival (LFS) between patients with RA/RARS and refractory cytopenia with multi-lineage dysplasia/refractory cytopenia with multi-lineage dysplasia and ringed sideroblasts (RCMD/RS-RCMD) (p = 0.0001). High-risk according to IPSS score and blood transfusion need were significantly predictive for a shorter survival and higher risk of transformation. Hemoglobin <10 g/dl, neutrophil count <0.5 x 10(9)/L, platelet count <50 x 10(9)/L had an unfavourable prognostic impact on survival in multi-variate analysis. Our conclusions support the previous findings on the value of WHO classification for prediction of prognosis in MDS.

Clinicohematological and cytogenetic profile of myelodysplastic syndromes in Pakistan-compare and contrast

“…The most common presenting complaint in our patients was loss of appetite followed by weakness. In our study mean Hb was 7.7 g/dl which is in concordance with a previous national study [1] and higher as compared to other studies done in Pakistan, China and India [2, 6, 8] and lower as compared to Turkey, Greece and Poland [9, 10, 15]. In our study, mean platelet count was 82 ×10 9 /l, which is in concordance with a national study and also seen in India [1, 8].…”

Clinicohematological and Cytogenetic Profile of Myelodysplastic Syndromes in Pakistan – Compare and Contrast

“…Monosomy 7 is not commonly observed in previous studies [3,6,[9][10][11][12][13]15] except for one study from India showing higher frequency [8]. CK in our study was observed to be lower as compared to China [6].…”

“…On the other hand refractory anemia (RA) was most commonly observed in China and Greece [6,10]. In our study, hypoplastic MDS was seen in 23 (13%) which is an interesting finding not observed in previous studies [1][2][3][6][7][8][9][10][11][12][13][14][15]. Refractory cytopenia of childhood (RCC) was observed in only one of our patients.…”

“…2). Mean hemoglobin (Hb), total leukocyte count (TLC), platelets, MCV at baseline and subtypes of MDS as per WHO classification in comparison with other national and international studies is shown in Table 1 [1][2][3][6][7][8][9][10][11][12][13][14][15].…”

Analysis of WHO-based Prognostic Scoring System (WPSS) of myelody-splastic syndrome and its comparison with international prognostic scoring system (IPSS) in 100 Chinese patients

“…Our study also supported this opinion. Many previous literatures did not take transfusion requirement as a hazard factor for OS of MDS, but recently many researchers found that transfusion dependency was an independent prognostic factor in MDS patients and can be considered as a reliable indicator of the severity of the disease [6,15,16] . In our study, the prognosis of patients with RBC transfusion dependency was obviously worse than the patients without RBC transfusion requirement.…”