The clinical features and surgical outcomes of pediatric patients with primary spinal cord tumor

Choi, Gwi Hyun; Oh, Jae Keun; Kim, Tae Yup; You, Nam Kyu; Lee, Hyo Sang; Yoon, Do Heum; Ha, Yoon; Yi, Seong; Kim, Do Kyung; Choi, Jina; Kh, Kim

doi:10.1007/s00381-012-1718-8

Cited by 30 publications

(27 citation statements)

References 15 publications

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“…3,11,13,24 A series of publications have already reported good outcomes (using the mMS) and determined the safety and efficacy of the best possible microsurgical tumor removal with the aid of intraoperative neurophysiological monitoring. 1,2,[5][6][7][8]12,14,17,18,21,25 No significant overall impact on reported QOL can be measured using the PedsQL 4.0 when comparing children with IMSCT and a healthy collective. There is only one minor exception to this conclusion: in the physical health item of the CSR score in the low-grade subgroup (Fig.…”

Section: Discussionmentioning

confidence: 99%

Quality of life after surgical treatment of primary intramedullary spinal cord tumors in children

Schneider¹,

Hidalgo²,

Schmitt‐Mechelke

et al. 2014

PED

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Object Presently, the best available treatment for intramedullary spinal cord tumors (IMSCTs) in children is microsurgery with the objective of maximal tumor removal and minimal neurological morbidity. The latter has become manageable with the development and standard use of intraoperative neurophysiological monitoring. Traditionally, the perioperative neurological evaluation is based on surgical or spinal cord injury scores focusing on sensorimotor function. Little is known about the quality of life after such operations; therefore, this study was designed to investigate the impact of surgery for IMSCTs on the quality of life in children. Methods Twelve consecutive pediatric patients treated for IMSCT were included in this retrospective fixed cohort study. A multidimensional questionnaire-based quality of life instrument, the Pediatric Quality of Life Questionnaire version 4 (PedsQL 4.0), was chosen to analyze follow-up data. This validated instrument particularly allows for a comparison between a patient cohort and a healthy pediatric sample population. Results Of 11 mailed questionnaires (1 patient had died of progressive disease), 10 were returned, resulting in a response rate of 91%. There were 8 low-grade lesions (5 pilocytic astrocytomas, 1 ganglioglioma, 1 hemangioblastoma, and 1 cavernoma) and 4 high-grade lesions (2 anaplastic gangliogliomas, 1 glioblastoma, and 1 glioneuronal tumor). The mean age at diagnosis was 7.5 years, the mean follow-up was 4.2 years, and 83% of the patients were male. Total resection was achieved in 5 patients and subtotal resection in 7. Four patients had undergone 2 or more resections. The 4 patients with high-grade tumors and 2 with incompletely resected low-grade tumors underwent adjuvant treatment (2 chemotherapy and 4 both radiotherapy and chemotherapy). The mean modified McCormick Scale score at the time of diagnosis was 1.7; at the time of follow-up, 1.5. The mean PedsQL 4.0 total score in the low-grade group was 78.5; in the high-grade group, 82.6. There was no significant difference in PedsQL 4.0 scores between the patient cohort and the normal population. Conclusions In a small cohort of children who had undergone surgery for IMSCTs with a mean follow-up of 4.2 years, quality of life scores according to the PedsQL 4.0 instrument were not different from those in a normal sample population.

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Section: Discussionmentioning

confidence: 99%

Quality of life after surgical treatment of primary intramedullary spinal cord tumors in children

Schneider¹,

Hidalgo²,

Schmitt‐Mechelke

et al. 2014

PED

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“…[19–21] GTR is recommended whenever feasible. Several studies have presented that GTR improved mortality in patients who have had primary malignant spinal cord tumors, [16,18,22] while a few studies found that GTR did not have any benefit and could even be associated with higher mortality. [5,23] Since primary spinal GBMs tend to be infiltrative and there is no distinct margin between tumor and surrounding normal cord tissue, [24] a STR or biopsy that does not cause further neurological dysfunction is appropriate in some cases.…”

Section: Discussionmentioning

confidence: 99%

Primary spinal glioblastoma multiforme

Shen

Zhao

et al. 2017

Medicine

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Rationale:Primary spinal glioblastoma multiforme (GBM) is a rare clinical entity with an aggressive course and an invariably dismal prognosis. Its clinical characteristics, radiologic and pathologic findings, and treatment protocols have been discussed in a few cases.Patient concerns:A 15-year-old female was admitted to the neurology department with a chief complaint of progressive numbness and weakness in her left upper extremity for 3 months and neck pain for 1 month.Diagnoses:Spinal magnetic resonance imaging showed an intramedullary expansile mass localized between C4 and C7. The diagnosis of GBM was determined on the basis of the histopathological findings after operation.Interventions:Laminotomy and laminoplasty between C4 and C7 were performed, and the tumor was partially resected. The patient was administered focal adjuvant radiotherapy concomitantly with oral chemotherapy following the surgery.Outcomes:With severe neurologic deficits at 13 months after the diagnosis, the patient expired.Lessons:Although therapeutic options have been improving, the prognosis of the primary spinal GBM remains poor. The treatment of primary spinal GBM entered into a central registry and multiple-center cooperation is important in establishing future therapeutic strategies.

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“…Intradural extramedullary tumors are most commonly schwannomas, myxopapillary ependymomas, and atypical teratoid/rhabdoid tumors. Finally, an intramedullary tumor should raise suspicion for low‐grade astrocytomas, ependymomas and gangliogliomas .…”

Section: Discussionmentioning

confidence: 99%

An 11‐Year‐Old Boy with A Sacral Spinal Mass

et al. 2015

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The clinical features and surgical outcomes of pediatric patients with primary spinal cord tumor

Abstract: PSCT in pediatric patients can be surgically removed with an acceptable low surgical morbidity. Progression-free survival was found to be related to the grade of tumor and the extent of tumor resection. Early diagnosis and treatment anticipate good functional neurologic outcome.

Cited by 30 publications

References 15 publications

Quality of life after surgical treatment of primary intramedullary spinal cord tumors in children

Quality of life after surgical treatment of primary intramedullary spinal cord tumors in children

Primary spinal glioblastoma multiforme

An 11‐Year‐Old Boy with A Sacral Spinal Mass

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