The Clinical Evaluation Doxepin — A New Psychotherapeutic Agent

Pitts, Norman E.

doi:10.1016/s0033-3182(69)71749-2

Cited by 25 publications

(3 citation statements)

References 2 publications

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“…The reported incidence of hypotension (2.6%) and tachycardia (2.9%) withdoxepin has been considerably lower than that occurring with amitriptyline (8.6% and 30%), and the former drug is apparently better tolerated in the elderly (68). The available information on this subject, however, is not sufficiently detailed to allow validation of this impression.…”

Section: Cardiovascular Effects At Therapeutic Levels In Manmentioning

confidence: 96%

A Review of the Cardiovascular Effects and Toxicity of Tricyclic Antidepressants

Jefferson

1975

Psychosomatic Medicine

227

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The tricyclic antidepressants have potent and complex effects on the cardiovascular system, both directly and through interactions with other drugs. Through a combination of anticholinergic activity, direct myocardial depressant activity and an effect on the adrenergic neuron, they can cause a combination of arrhythmias, blood pressure abnormalities and congestive heart failure. These changes, although most common with overdose, can occur at therapeutic levels. In addition a number of drug-drug interactions can occur between the tricyclics and agents used in the treatment of cardiovascular disease, as exemplified by tricyclic antagonism of the antihypertensive effect of guanethidine. Awareness of these factors is necessary to insure proper therapeutic utilization of the tricyclics as well as to treat effectively their toxicity.

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Section: Cardiovascular Effects At Therapeutic Levels In Manmentioning

confidence: 96%

A Review of the Cardiovascular Effects and Toxicity of Tricyclic Antidepressants

Jefferson

1975

Psychosomatic Medicine

227

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“…There was no evidence of any increased sensitivity to the hypotensive effects of doxepin in elderly patients (over 60 years), in whom the incidence of hypotension was 3.61 % (Pitts, 1969). In those patients receiving amitriptyline in the same studies, the incidence of hypotension was 8.56 %.…”

Section: Effect On Blood Pressurementioning

confidence: 77%

“…Only one instance of euphoria has been observed in 1,706 patients receiving doxepin for periods from a few weeks to 22 months (Pitts, 1969).…”

Section: Side-effectsmentioning

confidence: 99%