The Clinical Efficacy of the Repeated Transcervical Instillation of Quinacrine for Female Sterilization

Zipper, J; Medel, M; Goldsmith, A; Edelman, David A.; Pastene, Laura; Rivera, M

doi:10.1002/j.1879-3479.1976.tb00093.x

Cited by 13 publications

(5 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Studies have shown the use of quinacrine hydrochloride to be effective for permanent female sterilization [3][4][5][6]. The procedure requires multiple administrations to be effective.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of two insertions of 100-minute releasing quinacrine hydrochloride pellets for non-surgical female sterilization

Zipper

Rivera

et al. 1987

Adv Contracept

Self Cite

View full text Add to dashboard Cite

Extensive research has been undertaken to develop a simple method of non-surgica/ female sterilization. Zipper and associates identified quinacrine hydrochloride as a drug likely to produce tubal occlusion when placed into the uterus. Zipper's early work with a solution of quinaerine led to the development of quinacrine pellets, a delivery system that was designed to bring the quinacrine into prolonged contact with the tubal ostia through extended uterine retention.Three transcervica/ uterine insertions of 10-minute releasing quinacrine hydrochloride pellets performed at monthly intervals have produced a 12-month pregnancy rate of 3.3 per 100 women. The ultimate goal is to develop an effective, single insertion procedure, but the perfol~mance of the quinacrine pellets in occluding tubes has necessitated more than one insertion. FHI developed a 100-minute extended release pellet system with the expectation that more prolonged drug exposure would produce a higher rate of tuba/ closure. A study of the 100-minute releasing pellet system has been conducted in Santiago, Chile. Two monthly insertions in 112 women has resulted in a 12-month pregnancy rate of 2.0 per 100 women. Postproeedure problems occurring within the first year were reported by 13% of the women; most were minor and transitory./~dvances in Con~ion.

show abstract

“…Studies have shown the use of quinacrine hydrochloride to be effective for permanent female sterilization [3][4][5][6]. The procedure requires multiple administrations to be effective.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of two insertions of 100-minute releasing quinacrine hydrochloride pellets for non-surgical female sterilization

Zipper

Rivera

et al. 1987

Adv Contracept

Self Cite

View full text Add to dashboard Cite

show abstract

“…A comparison of results from studies conducted by Zipper show that the pellet method is an improvement over the solution method (14) (Table I). However, the procedure still requires three administrations of quinacrine before it is effective, thus, falling short of the ultimate goal of an effective, blind, one-insertion procedure.…”

Section: Quinacrine Pelletsmentioning

confidence: 99%

Nonsurgical Female Sterilization

Laufe

Cole

1980

Intl J Gynecology & Obste

View full text Add to dashboard Cite

Laufe LE, Cole LP (International Fertility Research Program, Research Triangle Park, NC, and Duke Medical Center, Durham, NC, USA). Nonsurgical female sterilization. Int J Gynaecol Obstet 18: 333-339, 1980 The development of a safe, effective nonsurgical method of female sterilization that can be performed by paramedical personnel remains a high priority. The method should have a blind delivery system and require only one application. Methyl cyanoacrylate and quinacrine hydrochloride are the two most promising chemical agents. Quinacrine has evolved from instillations of a solution to the development of pellets to the use of an IUD vector. By using an IUD vector to deliver the quinacrine, tubal occlusion can be achieved with a reduction in total dosage and with one insertion instead of the three necessary with the solution and pellet methods.

show abstract

“…Zipper and associates have observed that quinacrine has an occlusive effect on the intramural portion of the human fallopian tubes [1]. In spite of the extensive clinical studies [2][3][4][5][6] and others], histopathological research on the changes that occur when quinacrine is placed into the uterus is scarce [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Histopathologic changes in the cornual portion of the fallopian tube following a single transcervical insertion of quinacrine hydrochloride pellets

Elkady¹,

Mansy

Nagib³

et al. 1991

Adv Contracept

View full text Add to dashboard Cite

To study the sequence of histopathologic changes taking place in the cornual portion of the fallopian tube subsequent to exposure to quinacrine, 252 mg were inserted transcervically in 12 women awaiting hysterectomy for non-malignant conditions of the uterus. All patients who underwent surgery within ten days of insertion were found to have necrosis of the epithelial lining and an acute inflammatory reaction. Later on, the changes observed included progressive absorption of the inflammatory cellular exudate, progressive fibrosis, with partial or almost complete occlusion of the lumen, and failure of regeneration of the epithelial lining. Our results support other studies indicating that quinacrine can effectively produce tubal fibrosis and occlusion.

show abstract

The Clinical Efficacy of the Repeated Transcervical Instillation of Quinacrine for Female Sterilization

Cited by 13 publications

References 7 publications

Efficacy of two insertions of 100-minute releasing quinacrine hydrochloride pellets for non-surgical female sterilization

Efficacy of two insertions of 100-minute releasing quinacrine hydrochloride pellets for non-surgical female sterilization

Nonsurgical Female Sterilization

Histopathologic changes in the cornual portion of the fallopian tube following a single transcervical insertion of quinacrine hydrochloride pellets

Contact Info

Product

Resources

About