The clinical efficacy of fluconazole in the treatment of vulvovaginal candidiasis

Serov, V N; Буралкина, Н. А.; Борисенко, М. Ю.; Мамедова, Ф. Ш.

doi:10.21518/2079-701x-2016-2-60-63

Cited by 3 publications

(1 citation statement)

References 20 publications

(19 reference statements)

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“…С сожалением приходится констатировать, что флуканозол in vitro не обладал противогрибковой активностью в отношении большинства штаммов различных видов грибов. Вместе с тем, нельзя исключить, что в условиях организма человека этот препарат может оказывать фунгистатическое действие, о чём свидетельствуют некоторые клинические данные [16,17]. Тем не менее, при наличии антибиотикограммы более надёжным является выбор препарата с подтверждённой чувствительностью.…”

Section: результаты и обсуждениеunclassified

Species Diversity And Resistance Markers of <i>Candida</i> Yeasts In COVID Positive and COVID Negative Patients With Community-Acquired Pneumonia

Аронова

Tsymbalistova

et al. 2021

A&Ch

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Background. At the height of the novel coronavirus infection, the risk of fungal coinfection increases due to a decrease in the immune status of patients and massive antibacterial therapy, which leads to a complication in the course of the underlying disease and increases the risk of an unfavorable outcome. Therefore, it is necessary not only to identify all associates that cause the infectious process, but also to determine their sensitivity to antibacterial and antifungal drugs in order to select an adequate treatment regimen for a patient.The aim of the study was to investigate the species composition of fungal associates in corona positive and corona negative patients with community-acquired pneumonia (CAP), as well as to determine the spectrum of sensitivity/resistance of yeasts and yeast-like fungi to antimycotic drugs.Material and methods. The species composition of the fungal microﬂora in sputum samples from 723 patients with CAP, sent from a health care facility in Rostov-on-Don, was investigated. The isolated cultures were identiﬁed using bacteriological and mass spectrometric methods. The sensitivity of yeasts to antimycotic drugs was determined by disk-diﬀusion method.Results. It has been established that yeast and yeast-like fungi were present in sputum samples in 31–32% of patients with CAP in etiologically signiﬁcant quantities. 10 diﬀerent types of yeast and yeast-like fungi were identiﬁed. Candida albicans was the predominant species in terms of the number of isolated cultures (83%). A re-examination of corona positive patients after their hospital stay revealed a tendency towards an increase in the number and intensity of manifestation of candidal lesions. Moreover, a change in Candida species has been registered, which entails a change in their sensitivity to antifungal drugs. A high percentage of strains resistant to ﬂuconazole was identiﬁed after determining the sensitivity of fungi to antimycotics.Conclusion. The data obtained demonstrate that yeast and yeast-like fungi are the dominant associates in complicated forms of CAP. In this regard, it seems appropriate to provide individual microbiological support to patients during their treatment with the identiﬁcation of all pathogens.

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Section: результаты и обсуждениеunclassified

Species Diversity And Resistance Markers of <i>Candida</i> Yeasts In COVID Positive and COVID Negative Patients With Community-Acquired Pneumonia

Аронова

Tsymbalistova

et al. 2021

A&Ch

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The prediction of the spectrum of biological activity and antimicrobial properties of diaminoazoles

et al. 2019

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The work is devoted to predicting and studying biological properties of N-substituted analogs of 3,5-diamino-1,2,4-thiadiazole, which, in their turn, include in the composition of many drugs that exhibit a wide range of pharmacological actions. For searching of new alternative drugs with an antibacterial activity, but lacking resistance of microorganism strains to them, a computer screening of 2N-alkyl-substituted 5-amino-3-imino-1,2,4-thiadiazolines previously synthesized by us was carried out. The prediction of the spectrum of biological activity, as well as the determination of the probable toxicity of these compounds, was performed using the freely available computer programs PASS, Anti-Bac-Pred, and GUSAR. The study of the antibacterial activity in vitro against gram-positive (Staphylococcus aureus, Staphylococcus saprophyticus, Staphylococcus epidermidis) and gram-negative (Escherichia coli, Pseudomonas aeruginosae) bacterial strains was performed by the disco-diffusion method. Experimental data roughly correspond to the predictions.

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Management of patients with herpes-associated recurrent vulvovaginal candidiasis

Kovaleva

Ковалев

Арестова

2021

jour

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Objective. To develop a diagnostic algorithm, a rational method of treatment, and principles of preconception care in women with herpes-associated recurrent vulvovaginal candidiasis (RVVC).Materials and methods. We examined 68 patients with herpes-associated RVVC and 20 gynecologically healthy women.Results. It has been found that in RVVC it is necessary to study vaginal swab culture with the determination of the microorganism and its biofilm-forming ability in combination with viral DNA detection by the polymerase chain reaction (PCR) in vaginal secretion, determination of the IgG titer to the herpes simplex virus (HSV), the avidity index to HSV I and II. In the presence of laboratory-confirmed RVVC and HSV infection, it is necessary to assume the presence of an atypical course of HSV infection followed by complex antiviral and antimycotic therapy.Conclusion. The use of the developed algorithm of diagnostic and treatment interventions as preconception care makes it possible to address symptoms, reduce relapse rates and extend a non-relapse interval, prepare women with the mixed-infection for favorable pregnancy outcomes.

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The clinical efficacy of fluconazole in the treatment of vulvovaginal candidiasis

Cited by 3 publications

References 20 publications

Species Diversity And Resistance Markers of <i>Candida</i> Yeasts In COVID Positive and COVID Negative Patients With Community-Acquired Pneumonia

Species Diversity And Resistance Markers of <i>Candida</i> Yeasts In COVID Positive and COVID Negative Patients With Community-Acquired Pneumonia

The prediction of the spectrum of biological activity and antimicrobial properties of diaminoazoles

Management of patients with herpes-associated recurrent vulvovaginal candidiasis

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