The clinical effects of sodium hyaluronate, polyethylene glycol, and dextran-70 eye drops in relieving dry eye after phacoemulsification

Abstract

To compare the clinical efficacy of sodium hyaluronate eye drops, polyethylene glycol eye drops, and compound dextran eye drops in the treatment of dry eye after phacoemulsification of cataract. A total of 99 patients with dry eye after cataract phacoemulsification combined with intraocular lens implantation were treated in our hospital. Patients were divided into group A (sodium hyaluronate eye drops), group B (polyethylene glycol eye drops), and group C (dextran-70 eye drops). The clinical effect, tear film breakup time, basic tear secretion, corneal staining score, dry eye symptom score, and the incidence of ocular irritation were assessed. On the 3rd, 15th, 30th, and 60th day after operation, the tear film breakup time, corneal staining score, Schirmer I test, and dry eye symptom score in group A and group B were better than those in group C ( P < .05). In addition, there were no significant differences in tear breakdown time, corneal staining score, Schirmer I test, and dry eye symptom score between group A and group B ( P > .05). At 3 days to 60 days after operation, the incidence of dry eye in group A (12.12%) and group B (18.18%) was lower than that in group C (39.39%), and the incidence of dry eye in group A was significantly lower than that in group B ( P < .05). The effect of sodium hyaluronate eye drops elicited a greater beneficial impact as compared to polyethylene glycol eye drops and dextran-70 eye drops.

A comparison between hyaluronic acid and other single ingredient eye drops for dry eye, a review

“…Dextran‐70, represented in a single study of postoperative cataract patients, given three times daily, was found to be inferior to HA given one to four times daily in all subjective and objective measures (Duan & Tang, 2021), concentrations were not given.…”

“…Among the 23 included studies, there were two non‐randomised prospective‐longitudinal studies (Benitez‐del‐Castillo et al, 2002; Duan & Tang, 2021) with the remaining 21 studies being randomised controlled trials (RCTs) (Table 1). Seven studies were open‐label (Benitez‐del‐Castillo et al, 2002; Cui et al, 2018; Duan & Tang, 2021; Hwang et al, 2014; Jun et al, 2019; Park et al, 2017; Rolando & Valente, 2007), nine were single blinded (Brignole et al, 2005; Essa et al, 2018; García‐Conca et al, 2019; Gong et al, 2015; Kinoshita et al, 2013; Lee et al, 2011; McCann et al, 2012; Robert et al, 2016; Sanchez et al, 2010), and seven were double‐blinded (Johnson et al, 2008; Lambiase et al, 2017; Lee et al, 2006; Matsuo, 2004; Nelson & Farris, 1988; Takamura et al, 2012; Wu et al, 2021). Two studies had cross‐over design (Essa et al, 2018; Matsuo, 2004).…”

“…Drop frequency ranged from one to eight drops daily across all treatment arms (Table 1). Four studies used different drop frequencies in the study arm and HA arm (Duan & Tang, 2021; Essa et al, 2018; Kinoshita et al, 2013; Park et al, 2017). Figure 3 provides an overview of the major beneficial properties of each active ingredient.…”

“…Preservatives used across studies were benzalkonium chloride (BAK), chlorobutanol, sodium perborate and chlorhexidine (Table 1). Five studies compared treatments in which the study arm solution contained preservatives and the HA solution did not (Benitez‐del‐Castillo et al, 2002; Duan & Tang, 2021; Essa et al, 2018; Jun et al, 2019; Nelson & Farris, 1988). Two studies used formulations containing BAK in both treatment arms (Lee et al, 2006; Takamura et al, 2012).…”

Effect of combined use of sodium hyaluronate and rhEGF on xerophthalmia in the elderly after cataract surgery

“…Sodium hyaluronate eye drops are artificial tears which prevent loss of water from the eye surface, in addition to providing a stable tear film and moistening the eyeball, all of which relieve the symptoms of dry eyes and foreign body sensation in patients [17]. However, sodium hyaluronate eye drops contain a small amount of desiccant which irritates the cornea, especially if the drug is used for a long time.…”