The Clinical Effects of Nifedipine on Periodontal Status

Tavassoli, Samaneh; Yamalik, Nermin; Çağlayan, Feriha; Çağlayan, Gökhan; Eratalay, Kenan

doi:10.1902/jop.1998.69.2.108

Cited by 41 publications

(41 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the present study, the mean age of patients in the test group was 69.5 years and the age variable did not show a correlation with GO, in agreement with other studies [6, 9, 10, 17]. However, according to Thomason et al [18] and James et al [19], younger patients show a higher prevalence of GO when the association of nifedipine and cyclosporine treatment was identified.…”

Section: Discussionsupporting

confidence: 91%

Clinical Assessment of Nifedipine-Induced Gingival Overgrowth in a Group of Brazilian Patients

2011

View full text Add to dashboard Cite

Although it has been established that nifedipine is associated with gingival overgrowth (GO), there is little information on the prevalence and severity of this condition in the Brazilian population. The aim of this study was to assess the occurrence of nifedipine-induced GO in Brazilian patients and the risk factors associated using a Clinical Index for Drug Induced Gingival Overgrowth (Clinical Index DIGO). The study was carried out on 35 patients under treatment with nifedipine (test group) and 35 patients without treatment (control group). Variables such as demographic (age, gender), pharmacological (dose, time of use), periodontal (plaque index, gingival index, probing depth, clinical insertion level, and bleeding on probing), and GO were assessed. Statistical analysis showed no association between GO and demographic or pharmacological variables. However, there was an association between GO and periodontal variables, except for plaque index. According to our study, the Clinical Index DIGO can be used as a parameter to evaluate GO. Therefore, we conclude that the presence of gingival inflammation was the main risk factor for the occurrence of nifedipine-induced GO.

show abstract

Section: Discussionsupporting

confidence: 91%

Clinical Assessment of Nifedipine-Induced Gingival Overgrowth in a Group of Brazilian Patients

2011

View full text Add to dashboard Cite

show abstract

“…[46][47][48][49][50][51][52] Because the majority of studies are based on series of cases with a small number of patients, the true prevalence of nifedipine-induced gingival enlargement is unknown. 17,27,[53][54][55][56] On the other hand, predictors of gingival enlargement in patients treated with nifedipine have not been previously assessed. Therefore, the aim of the present study was to determine the prevalence, severity, and risk factors of gingival enlargement in a population of nifedipine-treated patients and to compare the results with those in a control group.…”

mentioning

confidence: 99%

Prevalence and Risk of Gingival Enlargement in Patients Treated With Nifedipine

Miranda

Brunet

Roset

et al. 2001

Journal of Periodontology

View full text Add to dashboard Cite

Background: Gingival enlargement is a known side effect of nifedipine use. This study was conducted to determine the prevalence and risk factors for gingival enlargement in nifedipinetreated patients.Methods: A cross-sectional study was conducted in a primary care center. Data from 65 patients taking nifedipine were compared with 147 controls who had never received the drug. All patients were examined for the presence of gingival enlargement using 2 different indices: vertical gingival overgrowth index (GO) in 6 points around each tooth, and horizontal MB index in the interdental area. Gingival index, plaque index, and probing depth were also evaluated.Results: The prevalence of gingival enlargement was significantly higher in nifedipine-treated cases than in controls (GO index, 33.8% versus 4.1%; MB index, 50.8% versus 7.5%, respectively). Higher gingival and plaque indices were observed in patients taking nifedipine. Among the possible risk factors, only the gingival index showed a significant association with gingival enlargement. The risk (odds ratio [OR]) of gingival enlargement associated with nifedipine therapy was 10.6 (3.8-29.1) for the GO index and 14.4 (6-34.6) for the MB index. Gingival index-adjusted ORs were 9.6 (3.3-28.1) and 9.7 (3.9-23.3), respectively. In the subset of high nifedipine exposure patients, the odds ratio for gingival enlargement increased to 17.4 (5.3-56.3) for the 3) for the MB index. The concordance between GO and MB indices showed a kappa value of 0.689 in controls and 0.642 in patients treated with nifedipine.Conclusions: Patients taking nifedipine are at high risk for gingival enlargement, and gingivitis acts as a predisposing factor. J Periodontol 2001;72:605-611.

show abstract

“…Another factor having an impact on the development of gingival hyperplasia is gender. It occurs three times more often in men than in women 11 . Our patient was a man with chronic renal failure.…”

Section: Discussionmentioning

confidence: 99%

Amlodipine-induced gingival hyperplasia in chronic renal failure: a case report

Aldemir¹,

Beğenik²,

Emre³

et al. 2013

Af Hlth Sci

View full text Add to dashboard Cite

Amlodipine is a dihydropyridine calcium channel blocker that is used in the management of both hypertension and angina. Amlodipine induced side effects are headache, dizziness, edema, flushing, palpitations, and rarely gingival hyperplasia. The exact reason of amlodipine-induced gingival hyperplasia is not known. We presented a case with chronic renal failure (CRF) that developed gingival hyperplasia due to amlodipine use, which improved after ceasing the drug.

show abstract

The Clinical Effects of Nifedipine on Periodontal Status

Cited by 41 publications

References 29 publications

Clinical Assessment of Nifedipine-Induced Gingival Overgrowth in a Group of Brazilian Patients

Clinical Assessment of Nifedipine-Induced Gingival Overgrowth in a Group of Brazilian Patients

Prevalence and Risk of Gingival Enlargement in Patients Treated With Nifedipine

Amlodipine-induced gingival hyperplasia in chronic renal failure: a case report

Contact Info

Product

Resources

About