The clinical course of IgA nephropathy after kidney transplantation and its management

Lionaki, Sophia; Panagiotellis, Konstantinos; Melexopoulou, C.; Boletis, John

doi:10.1016/j.trre.2017.01.005

Cited by 17 publications

(15 citation statements)

References 92 publications

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“…Each of these 4 elements may have a genetic component that influences the eventual phenotype of the disease in any individual. Moreover, the glycan-specific IgG that recognize the under-galactosylated IgA1 molecule often has reactivity against antigens from extrinsic microorganisms, adding more variability to the natural history of IgAN [2].…”

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confidence: 99%

“…Possible risks for individuals after transplantation include severe infection, allograft failure due to rejection, or death due to cardiovascular and neoplastic diseases; in addition, patients with IgAN face the risk of recurrent disease that may adversely affect long-term allograft function and, sometimes, lead to allograft loss [2].…”

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confidence: 99%

“…The natural course of the disease may be altered in the context of transplantation; immunosuppression with corticosteroids, azathioprine, and/or cyclosporine A does not seem prevent rIgAN, histological or clinically [2]. Among transplant recipients, there are no conclusive data about the relation between the immunosuppressive therapies and the risk of rIgAN.…”

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confidence: 99%

“…Among transplant recipients, there are no conclusive data about the relation between the immunosuppressive therapies and the risk of rIgAN. However, there is some nonsignificant evidence demonstrating that the use of steroids decreased the risk of graft loss due to recurrent IgAN [2][3][4]. Furthermore, the choice of the induction agent could play a role.…”

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confidence: 99%

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IgA Nephropathy Recurrence after Kidney Transplantation: Role of Recipient Age and Human Leukocyte Antigen-B Mismatch

et al. 2020

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Background: Recurrence of immunoglobulin (Ig)A nephropathy (rIgAN) is a growing cause of kidney allograft dysfunction. This study was aimed at investigating factors associated with rIgAN and the subsequent progression to end-stage renal disease (ESRD). Methods: Retrospective study including consecutive patients with IgA nephropathy (IgAN) who received a kidney transplant in our center between 1992 and 2016 and had a renal biopsy by clinical indication. The date of detection of chronic kidney disease (CKD) 5 was used as renal outcome. Results: Eighty-six kidney transplants were Developing a Risk Score of IgAN Recurrence 359 Am

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confidence: 99%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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IgA Nephropathy Recurrence after Kidney Transplantation: Role of Recipient Age and Human Leukocyte Antigen-B Mismatch

et al. 2020

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“…Past studies have shown that a substantial proportion of KTRs experience recurrent IgAN, which might lead to graft failure. However, the reported recurrence rates have varied considerably across studies, and the risk factors remain controversial …”

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confidence: 99%

Higher immunoglobulin A nephropathy recurrence in related‐donor kidney transplants: The Japan Academic Consortium of Kidney Transplantation study

et al. 2019

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Objective: To investigate the 10-year biopsy-proven recurrence rates and risk factors for immunoglobulin A nephropathy recurrence in kidney transplant recipients. Methods: We included 299 kidney transplant recipients from 1995 to 2015, who had biopsy-proven underlying immunoglobulin A nephropathy and underwent zero-hour biopsy. The primary end-point was recurrence of immunoglobulin A nephropathy. We compared clinical, treatment and graft failure among those with and without recurrent immunoglobulin A nephropathy. A time-to-recurrence analysis was carried out using the competing risk analysis and time-dependent Cox model. Results: Of 299 recipients, 80 had recurrent immunoglobulin A nephropathy (66.3% with clinical biopsy and 33.7% with protocol biopsy, post-transplant biopsy rate: 90.6%). The 10-year recurrence rate was 34.3% (95% confidence interval 27.6-41.1). Relateddonor transplantation (hazard ratio 2.28, P = 0.009) and post-transplant increased proteinuria (hazard ratio 1.59, P < 0.001) were identified as potential risk factors for immunoglobulin A nephropathy recurrence. The 10-year rates were 41.5% in related donor recipients and 16.3% in unrelated donor recipients. There was no conclusive evidence that the calcineurin inhibitor, antimetabolites, basiliximab and rituximab reduce immunoglobulin A nephropathy recurrence. Immunoglobulin A nephropathy recurrence was associated with an increased risk of death-censored graft failure (hazard ratio 5.29, 95% confidence interval 1.39-20.17, P = 0.015). However, related donor itself was not associated with an increased risk of graft failure. Conclusions: The present results have clinical implications in that the signs of recurrent immunoglobulin A nephropathy should be evaluated carefully in recipients receiving related-donor transplants. There is a need for further studies related to genetic and/or familial interactions in kidney transplant recipients with immunoglobulin A nephropathy and related donors. †Data from repeated determinations were analyzed by time-dependent Cox model. ‡Median [interquartile range].

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IgA Nephropathy

Oates¹

2018

Adolescents With Chronic Kidney Disease

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The clinical course of IgA nephropathy after kidney transplantation and its management

Cited by 17 publications

References 92 publications

IgA Nephropathy Recurrence after Kidney Transplantation: Role of Recipient Age and Human Leukocyte Antigen-B Mismatch

IgA Nephropathy Recurrence after Kidney Transplantation: Role of Recipient Age and Human Leukocyte Antigen-B Mismatch

Higher immunoglobulin A nephropathy recurrence in related‐donor kidney transplants: The Japan Academic Consortium of Kidney Transplantation study

IgA Nephropathy

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