The clinical course in pediatric solid tumor patients with focal nodular hyperplasia of the liver

Sugito, Kiminobu; Uekusa, Shota; Kawashima, Hiroyuki; Furuya, Takeshi; Ohashi, Keiji; Inoue, Masatoshi; Ikeda, Taro; Koshinaga, Tsugumichi; Tomita, Ryouichi; Mugishima, Hideo; Maebayashi, Toshiya

doi:10.1007/s10147-011-0210-x

Cited by 17 publications

(13 citation statements)

References 25 publications

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“…Among the 10 patients of our study, six had multiple lesions. The multiplicity of HLs observed in our study is in agreement with other reports on FNH diagnosed in oncologic patients: in fact, only 16 (37%) of the 43 patients in the literature showed solitary FNH (2,5,8,9,(14)(15)(16). The mean size of the lesions in our series was 19.8 mm (range 8-60 mm) compared with 3 cm (range 0.5-6; 2) and 1.5 cm (range 0.6-4; 8) reported in the two main studies on this topic.…”

Section: Discussionsupporting

confidence: 93%

Focal nodular hyperplasia of the liver in children after hematopoietic stem cell transplantation

Masetti

Zama

Gasperini

et al. 2013

Pediatric Transplantation

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FNH is a non-malignant neoplasia of the liver rarely described in children. A significant percentage of the pediatric cases have been reported in patients with a history of malignant disease treated with chemo-radiation therapy and in children who were given HSCT. Little is known about the pathogenesis of FNH in transplanted children, but many risk factors linked to the HSCT procedure have been hypothesized. The detection of hepatic nodules, particularly in children who underwent HSCT for a previous malignancy, always raises a diagnostic dilemma. To help the physicians in the diagnostic management of this rare entity, we have retrospectively evaluated a series of transplanted children diagnosed with FNH in our Center over the last 15 yr. In this period, we found 10 new diagnoses of FNH. The diagnostic work-up included CEUS, abdominal CT, and MRI. A liver biopsy was performed in two patients. The median FUP time after diagnosing FNH was 3.8 yr, with an abdominal US and no malignant transformation were observed. Possible risk factors and indications for the management of FNH in transplanted children are reported and discussed in a comprehensive review of the literature.

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Section: Discussionsupporting

confidence: 93%

Focal nodular hyperplasia of the liver in children after hematopoietic stem cell transplantation

Masetti

Zama

Gasperini

et al. 2013

Pediatric Transplantation

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“…FNH is the second most common benign lesion of the liver in humans and occurs more often in young females but can occur in both sexes of adults 55 , 56 , 57 , 58 , 59 , 60 . Cases in children have been reported 61 , 62 , 63 . FNH is a benign lesion, and in contrast to HCA, the risk of complications such as hemorrhage and malignant transformation is virtually absent.…”

Section: Discussionmentioning

confidence: 99%

Comparative Histomorphological Review of Rat and Human Hepatocellular Proliferative Lesions

et al. 2012

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In this comparative review, histomorphological features of common nonneoplastic and neoplastic hepatocyte lesions of rats and humans are examined using H&E-stained slides. The morphological similarities and differences of both neoplastic (hepatocellular carcinoma and hepatocellular adenoma) and presumptive preneoplastic lesions (large and small cell change in humans and foci of cellular alteration in rats) are presented and discussed. There are major similarities in the diagnostic features, growth patterns and behavior of both rat and human hepatocellular proliferative lesions and in the process of hepatocarcinogenesis. Further study of presumptive preneoplastic lesions in humans and rats should help to further define their role in progression to hepatocellular neoplasia in both species.

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“…A cumulative incidence is reported in oncologic pediatric patients after completion of therapy and differential diagnosis to other focal hepatic lesions, such as metastasis, is often challenging. Infants with neuroblastoma and metastatic hepatic disease seem to be a specific risk-group for FNH development, especially if they underwent chemotherapy and/or radiation therapy to the liver during treatment [21][22][23] . Gutweiler et al [24] reported a hepatoblastoma case presenting with FNH after treatment of neuroblastoma.…”

Section: Focal Nodular Hyperplasiamentioning

confidence: 99%

Differential diagnosis and management of liver tumors in infants

Fernández-Pineda

Cabello-Laureano

2014

WJH

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During the first year of life, most of the liver neoplasms are benign in origin, but some of these histologically benign lesions may be challenging in their management. Although most hepatic hemangiomas can be safely observed until involution is documented, some patients will need treatment due to progressive hepatomegaly, hypothyroidism and/or cardiac failure. Large mesenchymal hamartomas may require extensive hepatic resection and an appropriate surgical plan is critical to obtain good results. For malignant neoplasms such as hepatoblastoma, complete surgical resection is the mainstay of curative therapy. The decision about whether to perform an upfront or delayed resection of a primary liver malignant tumor is based on many considerations, including the ease of resection, surgical expertise, tumor histology and stage, and the likely chemosensitivity of the tumor. This article reviews the initial management of the more common hepatic tumors of infancy, focusing on the differential diagnosis and treatment options.

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The clinical course in pediatric solid tumor patients with focal nodular hyperplasia of the liver

Abstract: FNH appears to be a late complication of iatrogenic disease in NB stage 4 patients. The therapeutic agents for NB stage 4 and estrogen replacement therapy should be considered as risk factors for the development of FNH.

Cited by 17 publications

References 25 publications

Focal nodular hyperplasia of the liver in children after hematopoietic stem cell transplantation

Focal nodular hyperplasia of the liver in children after hematopoietic stem cell transplantation

Comparative Histomorphological Review of Rat and Human Hepatocellular Proliferative Lesions

Differential diagnosis and management of liver tumors in infants

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