The clinical course and standard therapy of systemic lupus erythematosus in the Russian Federation

Насонов, Евгений Львович; Соловьев, С. К.; Лила, А. М.

doi:10.14412/1996-7012-2016-2-12-16

RJTAO

2016

DOI: 10.14412/1996-7012-2016-2-12-16

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The clinical course and standard therapy of systemic lupus erythematosus in the Russian Federation

Евгений Львович Насонов¹,

С. К. Соловьев²,

А. М. Лила³

Abstract: Данные об особенностях клинического течения и лечения такого тяжелого заболевания, как системная красная волчанка (СКВ), в России практически отсутствуют. Цель исследования ESSENCE -оценка клинической картины заболевания и его лечения у взрослых пациентов с активной СКВ в го-родах трех постсоветских государств (Россия, Украина и Казахстан).Материал и методы. Настоящая публикация касается российских пациентов. Изучены данные (истории болезни) 232 пациентов, которые наблюдались в 6 центрах (Москва, Санкт-Петербу… Show more

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2020

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Clinical and laboratory relationships in patients with different variants of the course of systemic lupus erythematosus

Лила

2020

Sovremennaâ revmatologiâ

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Systemic lupus erythematosus (SLE) is characterized by a variability in clinical manifestations and laboratory abnormalities, which creates objective diagnostic difficulties.Objective: to investigate clinical and laboratory parameters in patients with definite and probable SLE.Patients and methods. The investigation enrolled 94 patients, 38 of whom were diagnosed with probable SLE. All the patients underwent immunological examination and unaffected skin biopsies, followed by an immunohistochemical study, the so-called lupus strip test (LST).Results and discussion. The group of patients with definite SLE showed a direct correlation between positive LST and disease activity (r=0.6), acute skin lesion (r=0.42), and elevated anti-double-stranded DNA antibody concentrations (r=0.37), and their inverse correlation with dry syndrome (r=-0.44). In patients with probable SLE, deposition of immunoreactants in the unaffected skin was detected in almost half of the cases, despite lower disease activity and specific antibody deficiency. Thus, LST that is quite easy to use and interpret its results can be used as an additional criterion for the differential diagnosis of SLE, especially in its early stages.

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Clinical and laboratory relationships in patients with different variants of the course of systemic lupus erythematosus

Лила

2020

Sovremennaâ revmatologiâ

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The clinical course and standard therapy of systemic lupus erythematosus in the Russian Federation

Cited by 1 publication

References 25 publications

Clinical and laboratory relationships in patients with different variants of the course of systemic lupus erythematosus

Clinical and laboratory relationships in patients with different variants of the course of systemic lupus erythematosus

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