The Clinical Characteristics of Neonatal Sepsis Infection in Southwest China

Jiang, Yongmei; Kuang, Linghan; Wang, Haijuan; Li, Lingping; Zhou, Wei; Li, Mingyuan

doi:10.2169/internalmedicine.55.3930

Cited by 23 publications

(18 citation statements)

References 20 publications

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“…infection were preterm low birth weight infants. The fungi infection rate in our study is similar to the results of Guo's study [24], but significantly higher than the results of 2 other studies conducted in other regions of China [13,14].…”

Section: Discussionsupporting

confidence: 86%

“…Coagulase-negative Staphylococcus (CoNS) is reported as the main pathogen of LOS [10][11][12]. However, the spectrum of pathogens varies among different regions and may change over time in the same place [13,14]. The investigation of organisms causing LOS and the monitoring of their antimicrobial sensitivity can be used to guide appropriate empirical treatment and help develop cost effective interventions to prevent neonatal deaths.…”

Section: Introductionmentioning

confidence: 99%

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Late-onset neonatal sepsis in Suzhou, China

Pan

Zhu

et al. 2020

BMC Pediatr

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Background: This study aimed to describe the causative organisms of neonatal late-onset sepsis (LOS) and their antimicrobial resistance in Suzhou, Southeast China over a 7-year period. Methods: We performed a retrospective study on neonates with LOS from Jan1, 2011 to Dec 31, 2017. The demographic, clinical, and laboratory data of neonates with LOS were analyzed. Logistic regression was used to investigate the risk factors with mortality. Results: During the study period, 202 neonates with LOS were finally identified. The most common pathogens were Escherichia coli (29.2%), followed by Klebsiella pneumoniae (19.3%), and Coagulase-negative Staphylococcus (CoNS) (16.8%). Nearly 90% of the K. pneumoniae were resistant to cefazolin and 71.8% to ceftazidime. Thirty-four patients (16.8%) died. Multivariable logistic regression showed that significant predictors of mortality were birth weight < 1500 g, respiratory distress and convulsions. Conclusions: Gram-negative organisms have an important role in LOS in our region, with high levels of resistance to third-generation cephalosporins. These data may help in the selection of antibiotics for empirical treatment of neonates with sepsis.

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Late-onset neonatal sepsis in Suzhou, China

Pan

Zhu

et al. 2020

BMC Pediatr

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“…Similar results were also found in several studies of previous neonatal sepsis. 8,9,14 Early-onset neonatal sepsis is caused by vertical transmission of bacteria from mother to fetus during the antenatal and intranatal period, while LONS is associated with the horizontal transmission of postnatally acquired pathogens. This transmission can occur due to risk factors for infection and lack of knowledge and awareness of pregnant women about danger signs such as fever and premature rupture of membrane.…”

Section: Discussionmentioning

confidence: 99%

The characteristics of neonatal sepsis in Low Birth Weight (LBW) infants at Sanglah General Hospital, Bali, Indonesia

Assa¹,

Artana²,

Kardana³

et al. 2020

Intisari Sains Medis

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Backgrounds: Neonatal sepsis is a significant cause of mortality and long-term morbidity. The preterm infant has high-risk sepsis and its sequelae. Low birth weight infants were more susceptible to sepsis. Initial infections in neonates may not be identified due to non-specific symptoms and sign with the limited laboratory criteria. This study aims to describe the characteristics of neonatal sepsis in low birth weight infants in the neonatology intensive care unit of Sanglah Hospital.Methods: A retrospective cross-sectional study was conducted among 168 infants aged zero to 28 days with birth weights <2,500 grams from May 2017 â€“ April 2018 at Sanglah General Hospital, Bali, Indonesia using a purposive sampling technique. The inclusion criteria were sepsis infants who were hospitalized in neonatology care rooms during the study period at Sanglah General Hospital. Variables assessed in this study were sex, location and mode of delivery, birth weight, gestational age, number of parity, length of stay, the onset of sepsis, as well as the outcome. Data were analysed using SPSS version 17 for Windows.Results: The mortality rate of sepsis in low birth weight infants was 29.8%. Most of the subjects were male (53%), location of delivery at Sanglah Hospital (60.7%), born spontaneously (51.2%), birth weight were 1500-2499 grams (58,3%) and the most gestational ages were 32-36 weeks (44,6%). Early-onset neonatal sepsis (EONS) dominates patients with neonatal sepsis, with a mean length of stay was 23.27Â±20.32 days. The major infection risk factor was premature rupture membrane (PRM) >24 hours (14.9%), and minor infection risk factor was gestational age <37 weeks (78%), very low birth weight (44.6%) and asphyxia (41.1%). The total blood culture positivity was 38 (22.6%) cases, and Enterococcus faecalis was the most common organism in this study.Conclusion: The incidence and mortality of neonatal sepsis in LBW infants were still high. The importance of knowledge and awareness of pregnant women about danger signs and the risk of infection can reduce the incidence of early-onset neonatal sepsis. Prevention of healthcare-associated infections can reduce the incidence of late-onset neonatal sepsis.

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“…In present study Gram-positive organisms had most sensitivity to vancomycin (84%) and linezolid (82%), which is comparable with a study in Karnataka, India which depicted 100% sensitivity from vancomycin and linezolid. 15,16 Sensitivity to teicoplanin (58%), piperacillin-tazobactam (42%), and fosfomycin (40%). Highest resistance was noted from Amoxyclav (52%).…”

Section: Discussionmentioning

confidence: 99%

Clinical and bacteriological profile of neonatal sepsis with emerging resistance patterns

Rajana

Bagri

Sharma

et al. 2018

Int J Contemp Pediatr

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Background: The present study was designed to evaluate the clinical spectrum, bacteriological profile, antibiotic sensitivity pattern and mortality due to neonatal septicemia in neonates admitted in neonatal units attached to the SMS Medical College, Jaipur.Methods: In born and out born babies of postnatal age up to 28 days who were bacteriological proven cases of septicemia were subjected to history, clinical examination and laboratory evaluation and data were analyzed statistically.Results: Out of 150 cases 67.33% neonates were preterm and 77.33% were low birth weight neonates. Gram negative organisms were most common cause of septicemia (66.6%), Both the Gram negative and Gram positive organisms were sensitive to piperacillin-tazobactam, linezolid, fosfomycin, teicoplanin, polymyxin B, colistin, ofloxacin. Both the Gram negative and Gram positive organisms were resistant against cephalosporins, ampicillin, Amoxyclav, cotrimoxazole. Gram negative isolates were most sensitive to Polymyxin B (70%) and had the highest resistance to cefepime (36%). Gram-positive organisms were most sensitive to vancomycin (84%) and linezolid (82%). Highest resistance was noted from Amoxyclav (52%).Conclusions: Preterm (<37 week) and low birth weight (<2500gm) neonates are considered as major susceptible causes of neonatal sepsis. Proper hygiene and hand washing, early detection of sepsis and judicial use of antibiotics to prevent multidrug resistance is needful in our setup.

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The Clinical Characteristics of Neonatal Sepsis Infection in Southwest China

Cited by 23 publications

References 20 publications

Late-onset neonatal sepsis in Suzhou, China

Late-onset neonatal sepsis in Suzhou, China

The characteristics of neonatal sepsis in Low Birth Weight (LBW) infants at Sanglah General Hospital, Bali, Indonesia

Clinical and bacteriological profile of neonatal sepsis with emerging resistance patterns

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