The clinical characteristics of adult bacterial meningitis caused by non‐Pseudomonas(Ps.)aeruginosa Pseudomonasspecies: A clinical comparison withPs. aeruginosameningitis

Huang, Chi-Ren; Lien, Chia-Yi; Tsai, Wan‐Chen; Lai, Wei-An; Hsu, Che-Wei; Tsai, Nai‐Wen; Chang, Chiung‐Chih; Lu, Cheng-Hsien; Chien, Chun-Chih; Chang, Wen-Neng

doi:10.1016/j.kjms.2017.08.007

Cited by 20 publications

(20 citation statements)

References 35 publications

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“…Mortality was zero. This is in vast contrast with the CNS infections caused by other micro-organisms, and even more specifically from P. aeruginosa, that carry significant mortality [2,20,21].…”

Section: Discussionmentioning

confidence: 90%

“…Among the 16 patients with P. mendocina infections, four (25%) involved CNS infections [2]. Among patients with CNS infections, 50% were male (two out of four) and the mean age was 69.5 years.…”

Section: Cns Infectionsmentioning

confidence: 99%

“…Hand screening of the included articles' references did not identify any additional studies. Thus, 12 studies met the inclusion criteria of the present study [2,3,[7][8][9][10][11][12][13][14][15][16]. Figure 1 shows a graphical representation of the review process.…”

Section: Literature Searchmentioning

confidence: 99%

“…It was first isolated from water and soil in Mendoza, Argentina in 1970, and was named after that [1]. Even though it is thought to cause infections quite rarely in humans, it can cause severe infections, such as infective endocarditis (IE) or central nervous system (CNS) infections, even in immunocompetent individuals [2,3]. The aim of this study was to systemically review all cases of human infection by P. mendocina in the literature and describe their epidemiology, microbiology, antimicrobial susceptibility, treatment and outcomes.…”

Section: Introductionmentioning

confidence: 99%

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A Systematic Review of Human Infections by Pseudomonas mendocina

Ιωάννου

Vougiouklakis

2020

TropicalMed

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Pseudomonas mendocina is a Gram-negative, rod-shaped, aerobic bacterium that belongs in the family Pseudomonadaceae and has been isolated from water and soil. Even though it is thought to cause infections quite rarely in humans, it can cause severe infections even in immunocompetent individuals. The aim of this study was to systemically review all cases of human infection by P. mendocina in the literature and describe their epidemiology, microbiology, antimicrobial susceptibility, treatment and outcomes. Thus, a systematic review of PubMed for studies providing epidemiological, clinical, microbiological as well as treatment data and outcomes of Pseudomonas mendocina infections was conducted. In total, 12 studies, containing data of 16 patients, were included. The commonest P. mendocina infections were infective endocarditis, central nervous system infections and skin and soft tissue infections (SSTIs). Fever was the main presenting symptom, while sepsis was evident in almost half the patients. Pseudomonas mendocina was susceptible to most antibiotics tested. Mortality was low in all different infection types. Third or fourth generation cephalosporins and quinolones are the commonest agents used for treatment, irrespectively of the infection site.

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Section: Discussionmentioning

confidence: 90%

Section: Cns Infectionsmentioning

confidence: 99%

Section: Literature Searchmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Systematic Review of Human Infections by Pseudomonas mendocina

Ιωάννου

Vougiouklakis

2020

TropicalMed

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“…Gram-negative bacterium found in cases of acute bacterial meningitis 35 Patient DGAP159 has the strongest homology to N. meningitidis (Fig. 3).…”

Section: Pseudomonas Putidamentioning

confidence: 99%

Parental infections disrupt clustered genes encoding related functions required for nervous system development in newborns

Friedenson¹

2018

Preprint

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The purpose of this study was to understand the role of infection in the origin of chromosomal anomalies linked to neurodevelopmental disorders. In children with disorders in the development of their nervous systems, chromosome anomalies known to cause these disorders were compared to viruses and bacteria including known teratogens. Results support the explanation that parental infections disrupt elaborate multi-system gene coordination needed for neurodevelopment. Genes essential for neurons, lymphatic drainage, immunity, circulation, angiogenesis, cell barriers, structure, and chromatin activity were all found close together in polyfunctional clusters that were deleted in neurodevelopmental disorders. These deletions account for immune, circulatory, and structural deficits that accompany neurologic deficits. In deleted gene clusters, specific and repetitive human DNA matched infections and passed rigorous artifact tests. In some patients, epigenetic driver mutations were found and may be functionally equivalent to deleting a cluster or changing topologic chromatin interactions because they change access to large chromosome segments. In three families, deleted DNA sequences were associated with intellectual deficits and were not included in any database of genomic variants. These sequences were thousands of bp and unequivocally matched foreign DNAs. Analogous homologies were also found in chromosome anomalies of a recurrent neurodevelopmental disorder. Viral and bacterial DNAs that match repetitive or specific human DNA segments are thus proposed to interfere with highly active break repair during meiosis; sometimes delete polyfunctional clusters, and disable epigenetic drivers. Mis-repaired gametes produce zygotes containing rare chromosome anomalies which cause neurologic disorders and accompanying nonneurologic signs. Neurodevelopmental disorders may be examples of assault on the human genome by foreign DNA with some infections more likely tolerated because they resemble human DNA segments. Further tests of this model await new technology.

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