The clinical characteristics and imaging findings of morning glory syndrome

Abstract

To investigate the features of CT, ultrasonography and fundus fluorescein angiography (FFA) of morning glory syndrome, the data on CT, A/B-scan ultrasonography and fundus fluorescein angiography (FFA) were retrospectively analyzed in 8 cases of morning glory syndrome (MGS). Among those cases, 6 were examined with CT, 4 with FFA and 8 with A/B-scan ultrasonography. Results showed that the characteristics of CT, A/B-scan ultrasonography and FFA in MGS included: (1) The attachment spot of optic nerve became thin and vitreous body protruded to the posterior wall of eyeball with a spherical shape on CT image; (2) in the early period of FFA, hypofluorescence appeared on the optic, the abnormal arteriae and veins around the optic papilla were displayed clearly and in the late period, optic disc was stained with fluorescein; (3) on B-scan ultrasonogram, the vitreous cavity extended to the posterior pole and optic papilla, and projected to the basal part of muscle cones and thus the posterior part of vitreous cavity looked like an upside-down bottleneck. Sometimes the echogenic band of retinal detachment could also be seen. On A-scan ultrasonogram, both vitreous cavity and bottleneck showed no ultrasonic echoes and presented a base line without any evident wave crest. It is concluded that CT, A /B-scan ultrasonography and FFA could show the imageological features of MGS from different aspects, which helps clinicians to differentiate it from other diseases such as optic disc coloboma. CT and A /B-scan ultrasonography, in particular, are considered to be reliable imageological methods for the accurate diagnosis of MGS and are superior to the traditional techniques.

Morning Glory Disc Anomaly: Characteristic MR Imaging Findings

“…Hu 17 reported protrusion of the vitreous through a defect in the posterior wall of the globe by using CT in 6 patients with MGDA and forebrain defects. Several studies have also used MR imaging to describe MGDA.…”

“…7,15,16 Second, cross-sectional imaging allows for evaluation of the globe in the setting of associated opacities of the refractive media, including persistent hyperplastic primary vitreous, which may mitigate the capacity to make this diagnosis on the basis of the funduscopic examination alone. 17 Finally, these patients may undergo imaging for unrelated clinical issues, and identification of the MGDA at imaging may be the only indicator to search for known associated intracranial abnormalities.…”

“…In particular, several groups have reported a defect in the posterior aspect of the globe, presumed to reflect the optic disc excavation observed clinically. [17][18][19] Auber and O'Hara 3 have expanded this work by identifying fluffy hyperintense tissue on T1-weighted MR images immediately adjacent to the "funnel-shaped" abnormality of the optic disc, a finding that may represent an imaging correlate of the chorioretinal pigmentary disturbance. 3 Unfortunately, these previous reports of at most 2 patients make it difficult to determine the consistency with which individual findings occur in this clinical setting.…”

Morning glory syndrome with Moyamoya disease: A rare association with role of imaging

“…This distinction is important because of the implications for genetics and family counseling; MGDA is almost universally a sporadic condition whereas optic nerve coloboma is commonly familial and may occur in association with multisystem congenital malformation syndromes. [ 13 14 ] Second, cross-sectional imaging permits for evaluation of the globe in the setting of associated opacities of the refractive media, including persistent hyperplastic primary vitreous, which may alleviate the capacity to make this diagnosis on the basis of the funduscopy examination alone. [ 14 ] Finally, these patients may undergo imaging for unrelated clinical issues, and identification of the MGDA at imaging may be the only indicator to search for known associated intracranial abnormalities.…”

The System Design of Spiral Drum Based on Parameterized Modules

“…Set of functional requirements is the market and customer requirements for the basic functions of the modular set of products; functional unit is the module's functions; function module is the product structure corresponding to the functional unit of product elements; structure module is a functional module of a specific module structure the general structure of the components or sub-modules; module structure of the module interface description in combination with each other geometry, the combination of the physical relationship between surface; module is the basic type design versatility, structural integrity of the structure of a typical zero-module; variations in the base module that type of module, based on changes in demand for specific functional modules derived some structural parameters of the module [2].…”