The clinical availability of non alcoholic fatty liver disease as an early predictor of the metabolic syndrome in Korean men: 5-Year's prospective cohort study

Ryoo, Jae‐Hong; Choi, Joong-Myung; Moon, Soo Young; Suh, Young Ju; Shin, Ju‐Young; Shin, Ho Cheol

doi:10.1016/j.atherosclerosis.2013.01.002

Cited by 34 publications

(33 citation statements)

References 36 publications

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“…To the best of our knowledge, this study is the first large scale prospective cohort study showing the availability of NAFLD as a predictor for the risk of MetS in the urban Han Chinese population. Similar results were found in other national and regional population, such as American in three ethnic groups [9], [10], health survey from western Australia [11], iron workers from Chinese southern population [12], [13], Korean men [2], [14], Japanese [15] and urban south Indians [16].…”

Section: Discussionsupporting

confidence: 86%

“…A series of cross-sectional studies have reported that NAFLD was linked with MetS and its components [7], [8]. Furthermore, various longitudinal or cohort studies demonstrated that NAFLD was associated with an increased risk of MetS from American in three ethnic groups [9], [10], health survey in western Australia [11], iron workers in Chinese southern population[12], [13], Korean men [2], [14], Japanese [15] and urban south Indians [16].…”

Section: Introductionmentioning

confidence: 99%

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Prediction of Metabolic Syndrome by Non-Alcoholic Fatty Liver Disease in Northern Urban Han Chinese Population: A Prospective Cohort Study

Zhang

et al. 2014

PLoS ONE

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ObjectivesTo explore the relationship between non-alcoholic fatty liver disease (NAFLD) and the metabolic syndrome (MetS), and evaluate the value of NAFLD as a marker for predicting the risk of MetS in a large scale prospective cohort from northern urban Han Chinese population.Materials and MethodsA total of 17,920 MetS-free at baseline cohort members was included in the current study between 2005 and 2011. The baseline characteristics of the cohort were compared by NAFLD status at baseline, MetS status after follow-up. Cox proportional hazards models were used to estimate the unadjusted or adjusted hazard ratios (HRs) for NAFLD at baseline predicting the risk of MetS.Results2,183 (12.18%) new cases of MetS occurred between 2005 and 2011. In unadjusted model, HRs (95% CIs) for NAFLD predicting MetS was 3.65 (3.35, 3.97). After adjusting the confounding factors of age, gender, the metabolic factors, smoke and exercise, the HRs (95% CIs) was 1.70 (1.55, 1.87). Gender difference was observed, adjusted HRs (95% CIs) of NAFLD for predicting MetS were 2.06(1.72, 2.46) and 1.55(1.39, 1.72) in female and male population, respectively. Moreover, 163 participants developed MetS among participants without any MetS component at baseline, and its adjusted HRs was still significant, 1.87 (1.12, 3.13).ConclusionThe present study indicates that NAFLD is an independent risk factor for predicting the risk of MetS in northern urban Han Chinese population, and the people with NAFLD should initiate weight and dietary control to prevent the occurrence of MetS.

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Prediction of Metabolic Syndrome by Non-Alcoholic Fatty Liver Disease in Northern Urban Han Chinese Population: A Prospective Cohort Study

Zhang

et al. 2014

PLoS ONE

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“…Few prospective studies have indicated that NAFLD can predict a higher incidence of MetS515253. A recent meta-analysis of prospective studies has demonstrated that NAFLD is associated with a nearly two-fold increased in the incident risk of type 2 diabetes and MetS.…”

Section: Discussionmentioning

confidence: 99%

“…Among the studies that have used US, the diagnoses were based on the presence of ultrasonographic patterns consistent with a “bright liver”, such as brightness and posterior attenuation. Only one cross-sectional study43 and one prospective study in Korea52 have used a scoring system to diagnose NAFLD. Hamaguchi et al .…”

Section: Discussionmentioning

confidence: 99%

Association of Non-alcoholic Fatty Liver Disease with Metabolic Syndrome Independently of Central Obesity and Insulin Resistance

Yang

Hung

et al. 2016

Sci Rep

110

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Non-alcoholic fatty liver disease (NAFLD) is an emerging chronic liver disease that may lead to liver cirrhosis and hepatocellular carcinoma. We aimed to determine the association between the prevalence of metabolic syndrome (MetS) and NAFLD severity using semi-quantitative ultrasonography (US). A total of 614 participants were recruited from the community. NAFLD was evaluated according to the ultrasonographic Fatty Liver Indicator (US-FLI), which is a semi-quantitative liver ultrasound score. Insulin resistance was estimated with the homeostasis model assessment index for insulin resistance (HOMA-IR). NAFLD and MetS were found in 53.7 and 17.3% of the participants, respectively. Linear relationships were found between the severity of NAFLD and waist circumference, fasting glucose, HOMA-IR, triglycerides, HDL-C and blood pressure. After adjusting for confounding factors, i.e., body mass index and HOMA-IR, the odds ratios for MetS were 3.64 (95% confidence interval (CI): 1.5–8.83) for those with mild NAFLD and 9.4 (95% CI: 3.54–24.98) for those with moderate-to-severe NAFLD compared to those without NAFLD. The combination of the HOMA-IR and US-FLI scores better differentiated MetS than the HOMA-IR alone. In addition to obesity, the severity of NAFLD and the HOMA-IR both play important roles in MetS. Whether NAFLD is a component of MetS warrants further research.

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“…[4][5][6][7][8][9][10][11][12][13][14][15] Moreover, more than a dozen of longitudinal studies with a relatively long duration of follow-up reported that NAFLD, as diagnosed by either ultrasonography or biochemistry, is independently associated with an increased incidence of several components of metabolic syndrome, not only of T2DM. 4,[16][17][18][19][20][21][22][23][24] Amongst the prospective studies that have used ultrasonography to diagnose NAFLD and that have assessed the risk of developing T2DM, the risk of T2DM varied markedly from an approximately 60% increase to approximately a sixfold increase in risk. [7][8][9][10][11][12][13][14][15] This wide interstudy variation in T2DM risk might reflect differences in NAFLD severity, as the study by Park et al 13 showed that the incidence rate of T2DM increased sharply according to the ultrasonographic severity of NAFLD at baseline (normal, 7%; mild, 9.8%; moderate-to-severe, 17.8%).…”

Section: Does Nafld Predict the Development Of T2dm And Metabolic Synmentioning

confidence: 98%

A Perspective on Metabolic Syndrome and Nonalcoholic Fatty Liver Disease

Targher

Byrne

2015

Metabolic Syndrome and Related Disorders

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Nonalcoholic fatty liver disease (NAFLD) is increasingly being diagnosed worldwide and is strongly associated with the features of metabolic syndrome. In this brief review, we discuss two key questions relating to NAFLD and metabolic syndrome: (1) Does NAFLD predict the development of type 2 diabetes mellitus and metabolic syndrome, or is it simply an epiphenomenon? (2) Are there differences between metabolic syndrome-associated NAFLD and NAFLD associated with genetic variation in the patatin-like phospholipase domain-containing 3 (PNPLA3) gene? Accumulating evidence indicates that NAFLD is not simply the hepatic manifestation of the metabolic syndrome, but is a pathogenic determinant of the syndrome. Genetic variation within the PNPLA3 gene (e.g., I148M homozygosity) confers a higher risk of developing more severe histological features of NAFLD, but a lower risk of developing metabolic syndrome traits. We suggest that future research is now required to elucidate whether both metabolic syndrome-related NAFLD and PNPLA3-related NAFLD produce the same risk of developing extrahepatic complications.

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The clinical availability of non alcoholic fatty liver disease as an early predictor of the metabolic syndrome in Korean men: 5-Year's prospective cohort study

Cited by 34 publications

References 36 publications

Prediction of Metabolic Syndrome by Non-Alcoholic Fatty Liver Disease in Northern Urban Han Chinese Population: A Prospective Cohort Study

Prediction of Metabolic Syndrome by Non-Alcoholic Fatty Liver Disease in Northern Urban Han Chinese Population: A Prospective Cohort Study

Association of Non-alcoholic Fatty Liver Disease with Metabolic Syndrome Independently of Central Obesity and Insulin Resistance

A Perspective on Metabolic Syndrome and Nonalcoholic Fatty Liver Disease

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