(With 2 figures in the text.)In studying the peripheral circulation we were confronted with the problem of measuring the venous pressure in the leg during walking. So far as we are aware this has not previously been done, though venous pressure during standing has been measured by many observers. These studies have been reviewed by Hooker and Eyster (1908), and by Eyster (1926Eyster ( ,1929. These papers contain positive indication that venous pressure is affected by muscular activity. For example, it has been shown in measuring standing venous pressure that unless precautions are taken to insure relaxation of the subject, the values will be too low. This can be explained only as the result of involuntary muscular activity pumping the blood out and reducing the pressure (Hooker, 1911;Carrier and Rehberg, 1923;McIntyre and Turner, 1935). That this pumping action would be increased during voluntary muscular activity was certain, but the extent of its effect in this case was not known; hence, it was important to measure the effect of this pumping action, if venous pressure determinations are to be useful in attacking problems of the peripheral circulation. Accordingly we have worked out the following method of measuring the venous pressure in a moving extremity.Various methods are used in determining standing venous pressure. All methods fall into one of two categories; direct or indirect, The data obtained by the two methods have been compared by 1 Der Redaktion am ZI. Oktober 1935 zugegangen.