The Clinical Application of Metabolic Therapy for Cardiovascular Disease

Myocardial Infarct Size-Limiting and Anti-Arrhythmic Effects of Mildronate Orotate in the Rat Heart

“…On the other hand, orotic acid represents a different means of metabolic therapy wherein a substance aims to correct an absolute or relative deficiency of a cellular components [15]. In line with several experimental studies that showed that orotic acid improves cardiac function after myocardial infarction, here we demonstrated the myocardial infarct size-limiting effect of 14-day pretreatment by orotic acid in an isolated rat heart model after 60 min occlusion and 150 min reperfusion period.…”

“…In line with several experimental studies that showed that orotic acid improves cardiac function after myocardial infarction, here we demonstrated the myocardial infarct size-limiting effect of 14-day pretreatment by orotic acid in an isolated rat heart model after 60 min occlusion and 150 min reperfusion period. Metabolic regulation has been discussed as a possible mechanism responsible for the cardioprotective effects of orotic acid and magnesium orotate [15,18]. Thus, orotic acid increased the glycogen content of the rat heart and significantly improved post-ischemic myocardial function both in vivo and in vitro in rat hearts subjected to 30 min of global noflow ischemia followed by 10 min of reperfusion [29].…”

“…Orotic acid possesses a profile of cardioprotective activity that is similar to that of mildronate, even though the pharmacological mechanisms of orotic acid are related to different metabolic pathways [15]. Thus, both orotic acid and its salt, orotate, have been shown to improve markedly the function of the heart in hypertrophy, infarction, global ischemia and related conditions [16][17][18][19].…”

Why did high-dose rosuvastatin not improve cardiac remodeling in chronic heart failure? Mechanistic insights from the UNIVERSE study

“…Given the known "pleiotropic" effects of statins, we evaluated effects on coenzyme Q10 levels and on markers of collagen turnover. Coenzyme Q10 (CoQ) is an integral component of the mitochondrial respiratory chain for energy production [10], and levels in serum and the myocardium have been shown to be low in CHF patients, with potential for further decrease in these levels with a statin, particularly in the elderly [11]. Coenzyme Q10 deficiency may exacerbate the poor contractility of myocardial cells in CHF patients because, in the setting of LV dysfunction, the myocardium demonstrates oxidative stress and coenzyme Q10 prevents lipid peroxidation [11].…”

Co-enzyme Q10 (Ubiquinone): It's Implication in Improving the Life Style of the Elderly

“…The congestive heart failure has been strongly linked to low blood and tissue levels of CoQ10 (1). The treatment with CoQ10 significantly improved the heart muscle function while producing no adverse effects or drug interactions [13][14][15].…”