The clinical application of mesenchymal stem cells in liver disease: the current situation and potential future

Zhang, Sainan; Yang, Yongrong; Fan, Linxiao; Zhang, Fen; Li, Lanjuan

doi:10.21037/atm.2020.03.218

Cited by 32 publications

(22 citation statements)

References 69 publications

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“…MSCs were shown to improve liver regeneration in patients with cirrhosis by elevating anti-apoptotic factors, such as HGF and IGF-1, and angiogenic and mitogenic factors. In acute liver failure animal models, MSCs have been shown to promote liver regeneration mostly by suppressing the oxidative stress and inflammation via reducing TNF-α, IFN-γ and IL-4 Levels and stimulating liver regeneration with various released factors such as PGE 2 and delta-like 4[ 153 , 154 ]. MSCs can also stimulate liver regeneration after PH by upregulating hepatic cell proliferation and downregulating fat accumulation and HGF, IL-6, IL-10 and TNF-α serum levels[ 155 ].…”

Section: Stimulation Of Insufficient Liver Regenerationmentioning

confidence: 99%

Molecular pathways of liver regeneration: A comprehensive review

Kiseleva¹,

Antonyan²,

Zharikova³

et al. 2021

WJH

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The liver is a unique parenchymal organ with a regenerative capacity allowing it to restore up to 70% of its volume. Although knowledge of this phenomenon dates back to Greek mythology (the story of Prometheus), many aspects of liver regeneration are still not understood. A variety of different factors, including inflammatory cytokines, growth factors, and bile acids, promote liver regeneration and control the final size of the organ during typical regeneration, which is performed by mature hepatocytes, and during alternative regeneration, which is performed by recently identified resident stem cells called “hepatic progenitor cells”. Hepatic progenitor cells drive liver regeneration when hepatocytes are unable to restore the liver mass, such as in cases of chronic injury or excessive acute injury. In liver maintenance, the body mass ratio is essential for homeostasis because the liver has numerous functions; therefore, a greater understanding of this process will lead to better control of liver injuries, improved transplantation of small grafts and the discovery of new methods for the treatment of liver diseases. The current review sheds light on the key molecular pathways and cells involved in typical and progenitor-dependent liver mass regeneration after various acute or chronic injuries. Subsequent studies and a better understanding of liver regeneration will lead to the development of new therapeutic methods for liver diseases.

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Section: Stimulation Of Insufficient Liver Regenerationmentioning

confidence: 99%

Molecular pathways of liver regeneration: A comprehensive review

Kiseleva¹,

Antonyan²,

Zharikova³

et al. 2021

WJH

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show abstract

“…Accumulating evidence supports that MSCs play therapeutic roles in a paracrine manner, especially through trophic factors (49)(50)(51)(52). Hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF) are the most widely reported trophic factors secreted by MSCs (46).…”

Section: Role Of Msc In Tissue Repair and Regenerationmentioning

confidence: 99%

The Application of Mesenchymal Stem Cells in the Treatment of Liver Diseases: Mechanism, Efficacy, and Safety Issues

et al. 2021

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Mesenchymal stem cell (MSC) transplantation is a novel treatment for liver diseases due to the roles of MSCs in regeneration, fibrosis inhibition and immune regulation. However, the mechanisms are still not completely understood. Despite the significant efficacy of MSC therapy in animal models and preliminary clinical trials, issues remain. The efficacy and safety of MSC-based therapy in the treatment of liver diseases remains a challenging issue that requires more investigation. This article reviews recent studies on the mechanisms of MSCs in liver diseases and the associated challenges and suggests potential future applications.

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“…Patients with end-stage liver cirrhosis often require liver transplantation. But this treatment is faced with many problems that are difficult to solve, for example, the shortage of liver source, high immune rejection, being prone to postoperative complications [ 3 ], and high cost associated with the operation, so its clinical application is limited [ 4 ]. In order to prevent liver disease from developing into its end-stage, mesenchymal stem cell (MSC) therapy has been adopted and has shown its potential in curing this kind of liver disease.…”

Section: Introductionmentioning

confidence: 99%

Progress of Interference of Traditional Chinese Medicine on Cirrhosis Treated with Bone Marrow Mesenchymal Stem Cells

Wang

Zhang

Wang

2021

Evidence-Based Complementary and Alternative Medicine

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Transplantation of bone marrow mesenchymal stem cells has attracted more and more attention as a regenerative therapy for the treatment of liver diseases. A large number of studies have shown that this kind of cells can inhibit the activation of hepatic stellate cells and regulate tissue homeostasis and immune system via a variety of ways. Meanwhile, bone marrow mesenchymal stem cells can inhibit apoptosis of hepatocyte, improve liver function, and reduce inflammation through multiple pathways. These cells have a broad prospect in the treatment of liver cirrhosis. At present, there are many studies on the specific mechanism of bone marrow mesenchymal stem cells transplantation in the treatment of liver cirrhosis. This paper reviews the pathogenesis of liver cirrhosis and the mechanism of bone marrow mesenchymal stem cells transplantation in the treatment of liver cirrhosis, discusses the effectiveness of traditional Chinese medicine method in enhancing the efficacy of bone marrow mesenchymal stem cells transplantation, and looks forward to its application prospect in the future.

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The clinical application of mesenchymal stem cells in liver disease: the current situation and potential future

Cited by 32 publications

References 69 publications

Molecular pathways of liver regeneration: A comprehensive review

Molecular pathways of liver regeneration: A comprehensive review

The Application of Mesenchymal Stem Cells in the Treatment of Liver Diseases: Mechanism, Efficacy, and Safety Issues

Progress of Interference of Traditional Chinese Medicine on Cirrhosis Treated with Bone Marrow Mesenchymal Stem Cells

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