The clinical application of glibenclamide: the problem of safety and efficacy

Abstract

Well-timed, effective, and safe therapy of type 2 diabetes mellitus (DM2) is a challenging problem for public healthcare systems all over the world. Glibenclamide is currently the most popular sulfanylurea derivative prescribed to the patients presenting with DM2. High requirements to the safety profile of modern medications including oral hypoglycemic agents imply the necessity of close attention to the potential problems associated with the long-term application of glibennclamide. The present review is focused on the topical problems of safety and efficacy of glibenclamide arising from its use in the clinical practice.