The clinical and serologic behavior of another example of anti‐In<sup>b</sup>

Sosler, Steven D.; Saporito, Catherine; Perkins, James T.; Unger, Phyllis J.; Orlina, Armando R.

doi:10.1046/j.1537-2995.1989.29589284154.x

Cited by 10 publications

(2 citation statements)

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“…In(b+) cord cells from babies born to mothers with immunoglobulin G1 anti-In b do not usually give a positive direct antiglobulin test (DAT), and anti-In b cannot usually be detected in the infants' sera. 17,20,32 In one case with maternal anti-In b of high titer, RBCs obtained from the baby yielded a positive DAT, and anti-In b could be eluted from them. 33 However, there was no sign of hemolytic disease of the newborn, and it is postulated that binding of anti-In b to CD44 on fetal monocytes and macrophages could have a blocking effect on FcγR1.…”

Section: Antibodies In the Systemmentioning

confidence: 98%

The Indian blood group system

Xu¹

2011

Immunohematology

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The Indian blood group system (ISBT: IN/023) consists of two antithetical antigens: In a (IN1), which is present in approximately 10 percent of some Arab populations and in 3 percent of Bombay Indians, and its allelic antigen In b (IN2), an antigen of high incidence in all populations. In 2007, two new high-incidence antigens were identified as belonging to the IN blood group system, namely IN3 (INFI) and IN4 (INJA). The antigens in this system are located on CD44, a single-pass membrane glycoprotein that is encoded by the CD44 gene on chromosome 11 at position p13. The biologic function of CD44 is as a leukocyte homing receptor and cellular adhesion molecule. The In a and In b polymorphism represents a 252G>C substitution of CD44, encoding R46P, and lack of IN3 and IN4 results from homozygosity for mutations encoding H85Q and T163R in the CD44 gene. The high-frequency antigen AnWj (901009) has not been assigned to the Indian system, but either is located on an isoform of CD44 or is closely associated with it. Immunohematology 2011;27:89-93.

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Section: Antibodies In the Systemmentioning

confidence: 98%

The Indian blood group system

Xu¹

2011

Immunohematology

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“…evidence to suggest that when alloimmunized SCD patients (responders) also have benign warm autoantibodies (a positive direct antiglobulin test) the transfusion of even antigen-negative RBCs (RBCs lacking the antigen for which the alloantibodies in the patient's serum are directed) can exacerbate the clinical significance of the autoantibody and cause the patient to develop severe clinical complkations [4]. Finally, it is expensive to screen for compatible, antigen-negative units of RBCs after alloimniunization has taken place.…”

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confidence: 99%

A simple, practical model for reducing alloimmunization in patients with sickle cell disease

et al. 1993

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Patients with sickle cell disease (SCD) form immune alloantibodies more frequently than other transfused populations because red cells (RBCs) from white donors (with a higher incidence of certain Rh, Duffy, Kell, and Kidd blood group antigens) are transfused to black patients often lacking these antigens. We propose a model to reduce alloimmunization in patients with SCD by providing them with blood from only black random donors. Rationale is shown by examining calculations based on the phenotype E-, C-, Fy(a-), K-, and Jk(b-). There is a 7% probability that this phenotype belongs to a white donor, while there is a 93% probability that this phenotype belongs to a black donor. The probability of selecting blood from a black donor identical with the above phenotype for black recipients from an all black population and from a typical urban blood inventory population (90% white, 10% black) is 1/4 and 1/33, respectively. Therefore, an 8-fold greater chance of selecting antigen non-identical blood occurs if blood is obtained from a typical urban donor population as compared to a black population. Based on these calculations, alloimmunization can be reduced prospectively in patients with SCD by meeting their transfusion requirements with blood selected from random black blood donors.

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Indian Blood Group System and the An Wjantigen

2002

Human Blood Groups

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The clinical and serologic behavior of another example of anti‐In^b

Cited by 10 publications

References 1 publication

The Indian blood group system

The Indian blood group system

A simple, practical model for reducing alloimmunization in patients with sickle cell disease

Indian Blood Group System and the An Wjantigen

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The clinical and serologic behavior of another example of anti‐Inb

Cited by 10 publications

References 1 publication

The Indian blood group system

The Indian blood group system

A simple, practical model for reducing alloimmunization in patients with sickle cell disease

Indian Blood Group System and the An Wjantigen

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The clinical and serologic behavior of another example of anti‐In^b