The clinical and histological effect of home-use, combination blue-red LED phototherapy for mild-to-moderate acne vulgaris in Korean patients: a double-blind, randomized controlled trial

Kwon, Hyuck Hoon; Lee, J.B.; Yoon, Ji Young; Park, S.Y.; Ryu, Ho-Youl; Park, B.M.; Kim, Y.J.; Suh, Dong Hye

doi:10.1111/bjd.12186

Cited by 83 publications

(79 citation statements)

References 29 publications

(36 reference statements)

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“…The mechanism of blue light inactivation of P. acnes occurs through photoexcitation of intracellular porphyrins and subsequent production of cytotoxic reactive oxygen species . Although the molecular mechanisms that might determine the clinical efficacy of blue light have not been fully explored, it has been suggested that blue light phototherapy can positively alleviate inflammatory but also noninflammatory acne lesions at the level of gene transcription by suppressing nuclear factor‐ κ B (NF‐ κ B) and inflammatory cytokines . There are insufficient randomized controlled studies on blue light therapy for acne.…”

Section: Discussionmentioning

confidence: 99%

An extension of a multicenter, randomized, split‐face clinical trial evaluating the efficacy and safety of chromophore gel‐assisted blue light phototherapy for the treatment of acne

et al. 2017

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A variety of laser/light-based devices have been reported to be effective for the treatment of acne, yet no long-term data on efficacy and safety have been published. A first 12-week clinical trial ("Main trial") recently demonstrated that the KLOX BioPhotonic System, an LED blue light device using photo-converter chromophores, can significantly improve moderate and severe facial acne vulgaris with an excellent safety profile. This Extension trial followed the Main trial, using the same BioPhotonic System, with the same dose and instructions for use, on patients having already completed treatment in the Main trial. Main objectives of this open-label long-term extension 12-week study were to evaluate the efficacy of the KLOX BioPhotonic System on the untreated hemiface during the Main trial, as well as the duration of response on the hemiface treated during the first 12-week Main trial. Despite their young age (mean age: 21.6 years) and their 12-week participation in the Main trial, 49 (54.4%) of the total number of patients who participated in the Main trial enrolled in this additional 12-week Extension trial. Baseline grading of acne was performed with the Investigator's Global Assessment (IGA) scale. For each patient, the hemiface randomly selected as a control during the Main trial received 6 weeks of treatment (twice weekly) and was then followed up for an additional 6 weeks. The first hemiface treated in the Main trial was consequently observed throughout the Extension trial, allowing for a further 12-week assessment of outcomes (total 24 weeks). In light of an additional 12 weeks of treatment on the contralateral face, the patient compliance rate was excellent, with 91.9% of the total number of patients receiving at least 80% of the treatments.Patients with a baseline IGA grade of 2 (mild) on the treated hemiface demonstrated a success rate of 58.3 and 66.7% at weeks 6 and 12, respectively. At these same time points, subjects with a baseline IGA grade of 3 (moderate) demonstrated a success rate of 81.8 and 90.0%. Patients with a baseline IGA grade of 4 (severe) demonstrated a success rate of 100% at both week 6 and week 12. When evaluating the originally treated hemifaces from the Main trial, the rate of return to baseline at 24 weeks was calculated to be 15.5%. This latter outcome confirmed the long duration of effect following treatment.The patient safety profile was also excellent, with very few related adverse events. The BioPhotonic System, which is comprised of LED blue light phototherapy and photoconverter chromophores, provides long-term efficacy and safety in the treatment of acne vulgaris, with a rate of compliance above what is generally observed in a young population of patients suffering from acne vulgaris, especially in light of sequential enrollment in a study treating one hemiface.

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Section: Discussionmentioning

confidence: 99%

An extension of a multicenter, randomized, split‐face clinical trial evaluating the efficacy and safety of chromophore gel‐assisted blue light phototherapy for the treatment of acne

et al. 2017

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“…Our experimental results showing decreases in SREBP-1 protein and gene expression, a master regulator of lipid synthesis in the sebaceous glands [25,26], might explain critical steps involved with sebosuppression. As possible upstream molecular events, attenuated activation of IGF-1/IGF-1 receptor system after antimicrobial activities of LFCO against P. acnes might lead to suppression of SREBP-1 [27,28]. A decrease in IGF-1R expression after LFCO treatment was observed.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Clinical and Histological Effects between Lactobacillus-Fermented Chamaecyparis obtusa and Tea Tree Oil for the Treatment of Acne: An Eight-Week Double-Blind Randomized Controlled Split-Face Study

Kwon¹,

Yoon²,

Park³

et al. 2014

Dermatology

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Background: Screening of natural compounds for the development of anti-acne therapeutic agents has been steadily required considering various side effects of acne medications. However, previous studies have mainly focused on experimental tests without clinical trials and histopathological analysis. Objectives: To compare the clinical efficacy, safety and histopathological changes between Lactobacillus-fermented Chamaecyparis obtusa (LFCO) and existing tea tree oil (TTO). Methods: A total of 34 patients were instructed to apply 5% LFCO to the involved areas of a randomly allocated side and 5% TTO extract to the other side for 8 weeks in a double-blind split-face clinical trial. Results: After 8 weeks, inflammatory acne lesions were reduced by 65.3% on the LFCO side and by 38.2% on the TTO side. LFCO was also superior to TTO in the onset time of efficacy (p < 0.05). The LFCO side further demonstrated improvement for non-inflammatory lesions (52.6%, p < 0.05), decreased size of sebaceous glands and sebum output reductions. Patients' subjective satisfaction was also higher without severe adverse reactions. Protein expressions of nuclear factor κB decreased earlier on the LFCO side, and those of interleukin-1a (IL-1a), IL-8, insulin-like growth factor 1 receptor and sterol regulatory element-binding protein 1 decreased subsequently. Ultra-performance liquid chromatography/high-resolution mass spectrometry further demonstrated that the contents of dihydroxybenzoic acid, taxifolin and quercetin were increased in LFCO after fermentation. Conclusions: LFCO treatment was rapid and effective for treating acne lesions compared to TTO. Histopathological findings correlated well with the clinical acne grade and treatment response. This novel natural compound appears to be effective and safe for acne treatment.

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“…However, the molecular mechanisms that might determine the clinical efficacy of combination blue and red light exposure have rarely been mentioned. While studying acne, Kwon [54] showed, from immunohistochemical studies, a decrease in IL-1a, IL-8 and MMP-9 levels which supports the theory that the anti-inflammatory effects of both blue and red light contribute synergistically to the mitigation of inflamed acne lesions at the level of gene transcription. Reduction of NF-kB activation might reasonably explain downstream cytokine expression, and reduction of TLR-2 could also be understood, as P. acnes triggers inflammatory cytokine responses in acne by activation of TLR-2 [55].…”

Section: Mode Of Actionmentioning

confidence: 68%

The effects of narrowbands of visible light upon some skin disorders: a review

Greaves

2016

Intern J of Cosmetic Sci

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This review article focuses on clinical studies published in the fields of (i) photorejuvenation and anti-ageing, (ii) oily or acne-prone skin and related imperfections, (iii) skin pigmentation and lightening, (iv) dandruff and other Malassezia-related skin disorders and (v) prevention and reversal of hair loss using non-thermal, nonablative devices (principally light-emitting diodes). It mainly focuses on clinical proof of performance and also on in vitro studies that support the clinical findings. The mode of action of narrowbands of visible light upon the skin is only briefly discussed since their biological effects have been previously reviewed.R esum e Cet article etablit une revue des etudes cliniques publi ees dans les domaines (i) du photorajeunissement et de l'anti-âge, (ii) de la peau grasse ou acn eique et des imperfections associ ees, (iii) de la pigmentation et de l' eclaircissement de la peau, (iv) des pellicules et des d esordres associ es a Malassezia et (v) de l'antichute et de la repousse du cheveu avec des appareils non-thermiques et non-destructifs (principalement les diodes electroluminescentes). L'article traite essentiellement de l'efficacit e clinique et des r esultats in vitro. Le m ecanisme d'action des bandes etroites de lumi ere visible sur la peau n'est que bri evement abord e, certains effets biologiques ayant d ej a et e publi es.

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The clinical and histological effect of home-use, combination blue-red LED phototherapy for mild-to-moderate acne vulgaris in Korean patients: a double-blind, randomized controlled trial

Abstract: This LED phototherapy was safe and effective for treating not only inflammatory but also noninflammatory acne lesions, with good compliance. The experimental results correlated well with clinical results, partly elucidating the related molecular mechanisms.

Cited by 83 publications

References 29 publications

An extension of a multicenter, randomized, split‐face clinical trial evaluating the efficacy and safety of chromophore gel‐assisted blue light phototherapy for the treatment of acne

An extension of a multicenter, randomized, split‐face clinical trial evaluating the efficacy and safety of chromophore gel‐assisted blue light phototherapy for the treatment of acne

Comparison of Clinical and Histological Effects between Lactobacillus-Fermented Chamaecyparis obtusa and Tea Tree Oil for the Treatment of Acne: An Eight-Week Double-Blind Randomized Controlled Split-Face Study

The effects of narrowbands of visible light upon some skin disorders: a review

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