The Clinical and Histologic Outcome of Dental Implant in Large Ridge Defect Regenerated With Alloplast: A Randomized Controlled Preclinical Trial

Kim, David M.; Nevins, M; Zhao, Lin; Fateh, Ardavan; Kim, Soo-Woo; Schüpbach, Peter; Nevins, Myron

doi:10.1563/aaid-joi-d-12-00242

Cited by 10 publications

(8 citation statements)

References 11 publications

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“…OSTEON ™ II Collagen is intended to be used for dental applications, including ridge augmentation, extraction socket grafting, cystic cavities, and periodontal defects. The product has a moldable property, so that it can accommodate any shape or form [63]. …”

Section: Commercially Available Mineralized Collagen Productsmentioning

confidence: 99%

“…Preclinical trials showed that a mineralized collagen composed of biphasic calcium phosphate (HA/β-TCP) and collagen were able to stimulate new bone formation in reconstruction of deficient alveolar ridges for dogs [63,79]. …”

Section: Clinical Applications Of Mineralized Collagen Productsmentioning

confidence: 99%

“…With the material development and higher clinical requirement of the GTR, the third generation membrane product possesses not only bioresorbability, but also osteoconductivity to accelerate osseous regeneration [81]. Bone augmentation effects of such new generation GTR membranes have been proved by many animal experiments [82,83], and some products are commercially available for clinical applications [63,79]. …”

Section: Clinical Applications Of Mineralized Collagen Productsmentioning

confidence: 99%

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Mineralized Collagen: Rationale, Current Status, and Clinical Applications

et al. 2015

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This paper presents a review of the rationale for the in vitro mineralization process, preparation methods, and clinical applications of mineralized collagen. The rationale for natural mineralized collagen and the related mineralization process has been investigated for decades. Based on the understanding of natural mineralized collagen and its formation process, many attempts have been made to prepare biomimetic materials that resemble natural mineralized collagen in both composition and structure. To date, a number of bone substitute materials have been developed based on the principles of mineralized collagen, and some of them have been commercialized and approved by regulatory agencies. The clinical outcomes of mineralized collagen are of significance to advance the evaluation and improvement of related medical device products. Some representative clinical cases have been reported, and there are more clinical applications and long-term follow-ups that currently being performed by many research groups.

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Section: Commercially Available Mineralized Collagen Productsmentioning

confidence: 99%

Section: Clinical Applications Of Mineralized Collagen Productsmentioning

confidence: 99%

Section: Clinical Applications Of Mineralized Collagen Productsmentioning

confidence: 99%

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Mineralized Collagen: Rationale, Current Status, and Clinical Applications

et al. 2015

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“…Collagenated biphasic calcium phosphate (CBCP) has recently received attention in the dental field [ 4 21 ]. As a bone substitute, CBCP shares the same basic characteristics of biphasic calcium phosphate (BCP), and exhibits comparable bone-regenerative potential [ 22 23 ]. As a carrier for rhBMP-2, the effectiveness of both BCP and CBCP has been demonstrated independently in several animal studies [ 3 4 21 24 ].…”

Section: Introductionmentioning

confidence: 99%

Comparative analysis of carrier systems for delivering bone morphogenetic proteins

Jung

Lim

Lee

et al. 2015

J Periodontal Implant Sci

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PurposeThe objective of this study was to comparatively assess the bone regenerative capacity of absorbable collagen sponge (ACS), biphasic calcium phosphate block (BCP) and collagenated biphasic calcium phosphate (CBCP) loaded with a low dose of recombinant human bone morphogenetic protein-2 (rhBMP-2).MethodsThe CBCP was characterized by X-ray diffraction and scanning electron microscopy. In rabbit calvaria, four circular 8-mm-diameter defects were created and assigned to one of four groups: (1) blood-filled group (control), (2) rhBMP-2-soaked absorbable collagen sponge (0.05 mg/mL, 0.1 mL; CS group), (3) rhBMP-2-loaded BCP (BCP group), or (4) rhBMP-2-loaded CBCP (CBCP group). The animals were sacrificed either 2 weeks or 8 weeks postoperatively. Histological and histomorphometric analyses were performed.ResultsThe CBCP showed web-like collagen fibrils on and between particles. Greater dimensional stability was observed in the BCP and CBCP groups than in the control and the CS groups at 2 and 8 weeks. The new bone formation was significantly greater in the BCP and CBCP groups than in the control and CS groups at 2 weeks, but did not significantly differ among the four groups at 8 week. The CBCP group exhibited more new bone formation in the intergranular space and in the center of the defect compared to the BCP group at 2 weeks, but a similar histologic appearance was observed in both groups at 8 weeks.ConclusionsThe dose of rhBMP-2 in the present study enhanced bone regeneration in the early healing period when loaded on BCP and CBCP in rabbit calvarial defects.Graphical Abstract

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“…26 Biphasic calcium phosphate (BCP) is frequently chosen for preventing flap collapse and carrying EMD in a clinical setting. 27,28 BCP has been demonstrated to have excellent osteoconductivity in various defects, [29][30][31] and its porous surface has advantages with respect to absorbing proteins and cell attachment. 32,33 The aim of this study was to determine the bone regenerative potential of EMD around dental implants in an in vivo animal model.…”

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confidence: 99%