The Clinical and Electroencephalography Findings of Children with Pervasive Developmental Disorder

Ayta, Semih; Gürses, Candan; Bilgen, Zerrin Topçu; Kılınçarslan, Ayşe; Eraksoy, Mefküre

doi:10.4274/tnd.67778

Cited by 3 publications

(1 citation statement)

References 31 publications

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“…We found no association between developmental regression and initial epileptiform EEG abnormalities (p=0.50). Regression is a salient feature of ASD thought to be a risk factor for the development of epilepsy with conflicting evidence [5,10,[14][15][16][17]. A retrospective review of 889 children with primary ASD failed to show an increased occurrence in sleep epileptiform EEG abnormalities in children with history of regression as compared to those without regression [5].…”

Section: Developmental Regression and Epileptiform Eeg Abnormalitiesmentioning

confidence: 99%

Evolution of EEG findings in children with autism spectrum disorder: A tertiary care centre's clinical experience

Thodeson¹,

Dowd²,

Golla³

et al. 2018

J Psychol Psychiatry

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Epilepsy and Autism Spectrum Disorder (ASD) are frequently co-morbid conditions. There are no clear testing modalities or biomarkers to distinguish children with ASD who are at risk for developing epileptic seizures from those who are not. Epileptiform electroencephalogram (EEG) abnormalities are common in children with ASD, suggesting a possible shared underlying pathophysiology with epilepsy. Our study analysed EEGs in children with ASD who underwent serial EEG studies. We show that initial EEG classification was a significant prognosticator for future EEG findings (p < 0.0001). Our study failed to demonstrate a statistically significant difference in the presence of epileptiform EEGs in children with ASD and co-morbid epilepsy as compared to those without co-morbid epilepsy. Furthermore, analysis of children with ASD and developmental regression or ASD and language impairment failed to demonstrate statistically significant differences in presence of epileptiform EEG abnormalities. Together these findings suggest that repeat EEGs should be obtained on a case-by-case basis in children with ASD and epileptiform EEG abnormalities in ASD in the absence of convincing epileptic seizures should be cautiously interpreted.

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Section: Developmental Regression and Epileptiform Eeg Abnormalitiesmentioning

confidence: 99%

Evolution of EEG findings in children with autism spectrum disorder: A tertiary care centre's clinical experience

Thodeson¹,

Dowd²,

Golla³

et al. 2018

J Psychol Psychiatry

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Prevalence and Age of Onset of Regression in Children with Autism Spectrum Disorder: A Systematic Review and Meta‐analytical Update

et al. 2021

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A systematic review published in 2013 reported 32% of children on the autism spectrum experience skill loss, known as autistic regression. However, the frequency varied depending on definition and measures used to capture skills. Retrospective parent report and prospective observation indicate loss of language and/or social skills, with motor skills typically unaffected. Our aim was to update the prevalence and age of onset of autistic regression through a meta‐analysis of the literature to understand if there have been changes to the reported onset and prevalence since 2010. A systematic literature search was conducted using Medline, Embase, PsycINFO, and the Cochrane Library databases and included studies published from 2010 onward. Risk of bias assessment was performed on included studies. A random effects model was used to calculate the pooled prevalence and age of onset of autistic regression. Ninety‐seven studies were included in the systematic review, of which 75 studies involving 33,014 participants had sufficient data for meta‐analytic syntheses. The pooled proportion of autistic regression was 30% (95% confidence interval [CI]: 27–32%) but heterogeneity was high (I2 = 96.91) and did not reduce with sensitivity or subgroup analyses based on study design or clinical differences, respectively. Prevalence varied according to risk of bias (low: 27%) and definition of regression (language: 20%, language/social: 40%, mixed: 30%, and unspecified: 27%). Weighted average age of onset was 19.8 months. Findings from this meta‐analysis highlight the importance of developing a standardized definition of autistic regression, and tools to measure this at multiple time points during early childhood development. Lay summary About a third of children with Autism Spectrum Disorder experience loss of skills, which is also known as autistic regression. This paper provides an update of the rate of autistic regression in children and the age when they first experience loss of skills, based on current studies. The findings from this review contribute to our understanding of the onset patterns of autistic regression. Unfortunately, studies are not sufficiently similar, making it difficult to provide clear answers on the exact timing or type of regression seen in different children.

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Factor associated with the occurrence of epilepsy in autism: a systematic review

Zarakoviti

Shafran

Skuse

et al. 2022

J Autism Dev Disord

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This systematic review aimed to identify factors significantly associated with the occurrence of epilepsy in autistic individuals and to consider the impact of study quality on findings. Electronic databases were systematically searched on October 2nd, 2020 and records retrieved were limited to those published from 2000 onwards. Study quality was categorised as ‘good’, ‘moderate’ or ‘weak’. Fifty-three studies were included and in studies where the prevalence of epilepsy was reported (n = 257,892), 18,254 (7%) had co-occurring epilepsy. Intellectual disability/cognitive impairment was the most commonly reported risk factor associated with occurrence of epilepsy in autistic individuals. The evidence supporting other, potentially relevant factors was weak and inconsistent and requires further evaluation. Only 9/53 studies were considered ‘good’ quality.

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The Clinical and Electroencephalography Findings of Children with Pervasive Developmental Disorder

Cited by 3 publications

References 31 publications

Evolution of EEG findings in children with autism spectrum disorder: A tertiary care centre's clinical experience

Evolution of EEG findings in children with autism spectrum disorder: A tertiary care centre's clinical experience

Prevalence and Age of Onset of Regression in Children with Autism Spectrum Disorder: A Systematic Review and Meta‐analytical Update

Factor associated with the occurrence of epilepsy in autism: a systematic review

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